{
  "url": "https://openlegislation.uk/control-of-substances-hazardous-to-health-regulations-2002/schedule-3/part-III",
  "json_url": "https://openlegislation.uk/control-of-substances-hazardous-to-health-regulations-2002/schedule-3/part-III.json",
  "legislation": "uksi/2002/2677",
  "legislation_title": "The Control of Substances Hazardous to Health Regulations 2002",
  "legislation_url": "https://openlegislation.uk/control-of-substances-hazardous-to-health-regulations-2002",
  "path": "schedule/3/part/III",
  "kind": "part",
  "number": "III",
  "heading": "CONTAINMENT MEASURES FOR INDUSTRIAL PROCESSES",
  "text": "Containment measures\nContainment levels\n2\n3\n4\n1\nViable micro-organisms should be contained in a system which physically separates the process from the environment (closed system).\nYes\nYes\nYes\n2\nExhaust gases from the closed system should be treated so as to—\nMinimise release\nPrevent release\nPrevent release\n3\nSample collection, addition of materials to a closed system and transfer of viable micro-organisms to another closed system, should be performed so as to—\nMinimise release\nPrevent release\nPrevent release\n4\nBulk culture fluids should not be removed from the closed system unless the viable micro-organisms have been—\nInactivated by validated means\nInactivated by validated chemical or physical means\nInactivated by validated chemical or physical means\n5\nSeals should be designed so as to—\nMinimise release\nPrevent release\nPrevent release\n6\nClosed systems should be located within a controlled area—\nOptional\nOptional\nYes, and purpose-built\n(a)biohazard signs should be posted;\nOptional\nYes\nYes\n(b)access should be restricted to nominated personnel only;\nOptional\nYes\nYes, via air-lock\n(c)personnel should wear protective clothing;\nYes, work clothing\nYes\nYes, a complete change\n(d)decontamination and washing facilities should be provided for personnel;\nYes\nYes\nYes\n(e)personnel should shower before leaving the controlled area;\nNo\nOptional\nYes\n(f)effluent from sinks and showers should be collected and inactivated before release;\nNo\nOptional\nYes\n(g)the controlled area should be adequately ventilated to minimise air contamination;\nOptional\nOptional\nYes\n(h)the controlled area should be maintained at an air pressure negative to atmosphere;\nNo\nOptional\nYes\n(i)input and extract air to the controlled area should be HEPA filtered;\nNo\nOptional\nYes\n(j)the controlled area should be designed to contain spillage of the entire contents of closed system;\nOptional\nYes\nYes\n(k)the controlled area should be sealable to permit fumigation.\nNo\nOptional\nYes\n7\nEffluent treatment before final discharge.\nInactivated by validated means\nInactivated by validated chemical or physical means\nInactivated by validated physical means",
  "extent": null,
  "status": null,
  "version": "current",
  "annotations": [],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/uksi/2002/2677/schedule/3/part/III",
    "retrieved_at": "2026-10-29T06:42:48.271696+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}