# The Control of Substances Hazardous to Health Regulations 2002, Part III: CONTAINMENT MEASURES FOR INDUSTRIAL PROCESSES


Containment measures
Containment levels
2
3
4
1
Viable micro-organisms should be contained in a system which physically separates the process from the environment (closed system).
Yes
Yes
Yes
2
Exhaust gases from the closed system should be treated so as to—
Minimise release
Prevent release
Prevent release
3
Sample collection, addition of materials to a closed system and transfer of viable micro-organisms to another closed system, should be performed so as to—
Minimise release
Prevent release
Prevent release
4
Bulk culture fluids should not be removed from the closed system unless the viable micro-organisms have been—
Inactivated by validated means
Inactivated by validated chemical or physical means
Inactivated by validated chemical or physical means
5
Seals should be designed so as to—
Minimise release
Prevent release
Prevent release
6
Closed systems should be located within a controlled area—
Optional
Optional
Yes, and purpose-built
(a)biohazard signs should be posted;
Optional
Yes
Yes
(b)access should be restricted to nominated personnel only;
Optional
Yes
Yes, via air-lock
(c)personnel should wear protective clothing;
Yes, work clothing
Yes
Yes, a complete change
(d)decontamination and washing facilities should be provided for personnel;
Yes
Yes
Yes
(e)personnel should shower before leaving the controlled area;
No
Optional
Yes
(f)effluent from sinks and showers should be collected and inactivated before release;
No
Optional
Yes
(g)the controlled area should be adequately ventilated to minimise air contamination;
Optional
Optional
Yes
(h)the controlled area should be maintained at an air pressure negative to atmosphere;
No
Optional
Yes
(i)input and extract air to the controlled area should be HEPA filtered;
No
Optional
Yes
(j)the controlled area should be designed to contain spillage of the entire contents of closed system;
Optional
Yes
Yes
(k)the controlled area should be sealable to permit fumigation.
No
Optional
Yes
7
Effluent treatment before final discharge.
Inactivated by validated means
Inactivated by validated chemical or physical means
Inactivated by validated physical means

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Source: https://www.legislation.gov.uk/uksi/2002/2677/schedule/3/part/III (the official version)
Page: https://openlegislation.uk/control-of-substances-hazardous-to-health-regulations-2002/schedule-3/part-III
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.