# The Cosmetic Products (Safety) Regulations 1989, Schedule 1: LIST OF SUBSTANCES WHICH COSMETIC PRODUCTS MUST NOT CONTAIN


The alphabetical list set out in column 2 of this Schedule contains one or more of the names of each of the substances referred to in regulation 4(2); in certain cases a name is given of a group of substances, the names of particular examples of which are also given, and in such a case all substances comprised in the group are included, whether or not more specifically named.
The numbers given in columns 1, 3 and 4 are for information only. Those in column 3 are cross-references to other names listed for the same substances (except that where a name is that of a group of substances, the cross-references are to particular examples of that group, and any cross-reference in parenthesis is to the name of a group of substances within which the particular substance falls). Those in column 4 are cross-references to Annex II of the Directive, from which this Schedule is derived.
(1)
(2)
(3)
(4)
Number in this Schedule
Name of substance
Cross-reference to this Schedule
Cross-reference to Annex II of the Directive
1
Acenocoumarol (INN)
3
254
2
3-(α-Acetonylbenzyl)-4-hydroxycoumarin and its salts
372, 704
203
3
3-(α-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin
1
254
4
2-(or β-)Acetoxyethyltrimethylammonium hydroxide and its salts
6
2
5
2-Acetylamino-5-chlorobenzoxazole
151
1
6
Acetylcholine and its salts
4
2
7
Acetylene chlorides
227, 702
126
8
Acetylenic alcohols, their esters, ethers and salts
17
16
9
Acetylethyltetramethyltetralin (AETT)
317
362
10
β-(7α-Acetylthio-17β-hydroxy-3-oxoandrost-4-en-17α-yl)propionic acid lactone
599
4
11
Aconitine and its salts
—
12
12
Aconitum napellus L.(leaves, roots and galenical preparations)
—
11
13
Adonis vernalis L. and its preparations
—
13
14
Adrenaline
249, 294
14
15
Alkali pentacyanonitrosylferrate (2-)
563–4, 594–5
255
16
O-Alkyldithiocarbonic acids, salts of
705
336
17
Alkyne alcohols, their esters, ethers and salts
8
16
18
Alloclamide (INN) and its salts
22
19
19
Allyl isothiocyanate
—
18
20
2-(4-Allyl-2-methoxyphenoxy)—N,N-diethylacetamide and its salts
—
224
21
N-Allylnormorphine, its salts and ethers
460
20
22
2-Allyloxy-4-chloro—N-[2'-(diethylamino)ethyl]benzamide and its salts
18
19
23
Alypine and its salts
45, 103
143
24
Ambenomium chloride (INN)
(492)
132
25
4-(orp-)Aminobenzoic acid esters except glycerol 1-(4-aminobenzoate) when provisionally permitted for use as a UV filter in accordance with the requirements specified in item 4 of Part II of Schedule 5
—
167
26
2-Amino-1,2-bis(4-methoxyphenyl) ethanol and its salts
—
29
27
3-Amino-4-butoxybenzoic acid 2-diethylaminoethyl ester and its salts
95, 234
23
28
Aminocaproic acid (INN) and its salts
32
7
29
2-Amino-5-chlorobenzoxazole
710
24
30
4-Amino—N-(2'-diethylaminoethyl) benzamide, its salts and derivatives
566
23
31
Aminoheptane, its isomers and salts
695
27
32
6-Aminohexanoic acid and its salts
28
7
33
α-(Aminomethyl)-3,4-dihydroxybenzyl alcoholand its salts
483, 484
257
34
4-Amino—N10-methylfolic acid
425
6
35
2-Amino-6-methylheptane and its salts
390, 489
28
36
2-Amino-4-methylhexane and its salts
267, 442
30
37
2-Amino-4-nitrophenol
—
383
38
2-Amino-5-nitrophenol
—
384
39
4-(orp-)Aminosalicylic acid and its salts
—
31
40
Aminotoluenes, their isomers, salts and halogenated and sulphonated derivatives
662
32
41
Aminoxylenes, their isomers, salts and halogenated and sulphonated derivatives
707
33
42
Amitriptyline (INN) and its salts
263
146
43
Ammi majus and its galenical preparations
—
35
44
Amphetamine (INN), its salts and derivatives and salts of those derivatives
(625)
21
45
Amydricaine and its salts
23, 103
143
46
Amylene chloride
228
36
47
Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN))
496
381
48
Amyl nitrites
—
247
49
Amylobarbitone and its salts
(68)
220
50
Amylocaine and its salts
261
50
51
Anamirta cocculus L.(fruit)
—
106
52
Substances with androgenic effect
—
37
53
Aniline, its salts and halogenated and sulphonated derivatives
—
22
54
Anthracene oil
—
38
55
Antibiotics (except tyrothricin)
—
39
56
Antimony and its compounds
—
40
57
Apocynum cannabinum L. and its preparations
—
41
58
Apomorphine and its salts
641
42
59
Apronalide
393
216
60
Arecoline
451
238
61
Aristolochic acid and its salts
—
365
62
Arsenic and its compounds
—
43
63
Atropa belladonna L. and its compounds
—
44
64
Atropine, its salts and derivatives
—
45
65
Azacyclonol (INN) and its salts
285
286
66
Azamethonium bromide (INN)
443
121
67
Barbitone and its salts
(68)
220
68
Barbiturates
various
220
69
Barium salts (except barium sulphate, barium sulphide under the condition laid down in Part I of Schedule 2, for alkaline earth sulphides and lakes, salts and pigments prepared from those colouring agents identified in Column 1 of Schedule 3 by “*” immediately after the name or colour index number)
—
46
70
Bemegride (INN) and its salts
311, 312
183
71
Benactyzine (INN)
235
157
72
Bendrofluazide and its derivatives
73, 86
53
73
Bendroflumethiazide (INN) and its derivatives
72, 86
53
74
Benzamine and its salts
688
51
75
Benzatropine (INN) and its salts
281
158
76
Benzazepines, their salts and derivatives
85
49
77
Benzene
—
47
78
2-Benzhydryloxyethyldimethylamine and its salts
276
339
79
Benzidine
221
26
80
Benzilonium bromide (INN)
90
60
81
2-Benziloyloxymethyl-1,1-dimethylpyrrolidinium methylsulphate
561
239
82
Benzimidazolone
83, 244
48
83
Benzimidazol-2(3H)-one
82, 244
48
84
Benzoates of 4-hydroxy-3-methoxycinnamyl alcohol (except natural content of essences)
191
357
85
Benzodiazepines, their salts and derivatives
76
49
86
Benzothiadiazine and its derivatives
72, 73
53
87
Benzoyl peroxide
—
382
88
3-(N-Benzylhydrazinocarbonyl)-5-methylisoxazole
387
52
89
Benzylideneacetone
527
356
90
3-Benzyloxy-1,1-diethylpyrrolidine hydrobromide
80
60
91
4-Benzyloxyphenol
(366, 456)
178
92
2-[Benzyl—N-(2-pyridyl)amino]-ethyldimethylamine
581, 692
347
93
Beryllium and its compounds
—
54
94
Betamethasone (INN)
(337)
300
95
Betoxycaine (INN) and its salts
27, 95, 234
23
96
BHC (ISO) (gamma-BHC)
346, 348, 401
195
97
Bietamiverine (INN)
238
287
98
1,6-Bis(2-chloroethylamino)-1,6-dideoxymannitol and its salts
409
89
99
2-[Bis(2-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide and its salts
102, 211
88
100
N,N-Bis(2-chloroethyl)methylamine and its salts
148, 458
87
101
N,N-Bis(2-chloroethyl)methylamine N-oxide and its salts
459
86
102
N,N-Bis(2-chloroethyl)—N',O-propylenephosphoramide anhydride and its salts
99, 211
88
103
1,1-Bis(dimethylaminomethyl)propyl benzoate and its salts
23, 45
143
104
2,2-Bis(hydroxymethyl)butan-1-ol trinitrate
572
206
105
2,6-Bis(β-hydroxyphenethyl)-1-methylpiperidine and its salts
403
219
106
Bithionol (INN)
651
352
107
Bretylium tosilate (INN) (or tosylate)
110
56
108
Bromine, elemental
—
55
109
Bromisoval (INN)
113
58
110
p-Bromobenzylethyldimethylammoniump-toluenesulphonate
107
56
111
Bromodiethylacetylurea
112, 139
57
112
α-Bromo-α-ethylbutyrylurea
111, 139
57
113
Bromoisovalerylurea
109
58
114
1—p-bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane and its salts
115
59
115
Brompheniramine (INN) and its salts
114
59
116
Brucine
—
62
117
Butanilicaine (INN) and its salts
438
90
118
Butobarbitone and its salts
(68)
220
119
Butopiprine (INN) and its salts
121
288
120
2-Butoxy—N-(2-diethylaminoethyl) cinchoninamide and its salts
178
129
121
2-Butoxyethyl α-phenyl-α-(N-piperidino)acetate and its salts
119
288
122
1-Butyl-3-(N-crotonoylsulphanilyl) urea
—
108
123
4-Butyl-1,2-diphenylpyrazolidine-3,5-dione
526
67
124
4-Butyl-1-phenylpyrazolidine-3,5-dione
455
64
125
1-Butyl-3-(p-methylbenzenesulphonyl) urea
661
65
126
1-Butyl-3-sulphanilylurea
140
66
127
4-Butylthiobenzohydryl dimethylaminoethyl sulphide
133
140
128
Cadmium and its compounds
—
68
129
Calabar bean
547
281
130
Cantharides,Cantharis vesicatoria
597
69
131
Cantharidin
354
70
132
Captan (ISO)
680
370
133
Captodiame (INN)
127
140
134
Caramiphen (INN) and its salts
530
169
135
N-(3-Carbamoyl-3,3-diphenylpropyl)—N,N-diisopropylmethylammonium salts
392
156
136
Carbazole, nitroderivatives of
476
72
137
Carbon disulphide
—
73
138
Carbon tetrachloride
637
315
139
Carbromal (INN)
111, 112
57
140
Carbutamide (INN)
126
66
141
Carisoprodol (INN)
449
235
142
Catalase
—
74
143
Cephaeline and its salts
—
75
144
Chenopodium ambrosioides(essential oil)
—
76
145
Cherry laurel water
577
291
146
Chloral hydrate
677
77
147
Chlorine
—
78
148
Chlormethine (INN) and its salts
100,458
87
149
Chlormezanone (INN)
162
91
150
5-Chlorobenzoxazolinone
173
82
151
N-5-Chlorobenzoxazol-2-ylacetamide
5
1
152
2-Chloro-4-dimethylamino-6-methylpyrimidine
157, 196
83
153
2-Chloro-9-(α-dimethylamino-propylidine)thioxanthene (trans-form) and its salts
170
84
154
4-Chloro-1,3-disulphamoylbenzene
181
85
155
Chloroethane
305
96
156
Chloroform
679
366
157
2-Chloro-6-methylpyrimidin-4-yldimethylamine
152, 196
83
158
Chlorophacinone (ISO)
163
93
159
1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine
376
240
160
4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
345
185
161
2-(4-Chlorophenyl)-3-methylbutane-2,3-diol
516
95
162
2-(4-Chlorophenyl-3-methyl-4-metathiazonone-1,1-dioxide
149
91
163
2-[2-(4-Chlorophenyl)-2-phenylacetyl]indan-1,3-dione
158
93
164
1-(4-Chlorophenyl)-1-phenyl-1-dimethylaminoethoxyethane
167
94
165
Chloropicrine
—
325
166
3-(4-Chloro-3-sulphamoylphenyl)-3-hydroxyisoindolin-1-one
171, 172
262
167
Chlorphenoxamine (INN)
164
94
168
Chlorpromazine (INN)
(521)
320
169
Chlorpropamide (INN)
573
79
170
Chlorprothixene (INN) and its salts
153
84
171
Chlortalidone (INN)
166, 172
262
172
Chlorthalidone
166, 171
262
173
Chlorzoxazone (INN)
150
82
174
Cholecalciferol
(703)
335
175
Choline salts and their esters
—
168
176
Chromium, chromic acid and salts of the acid
—
97
177
Chrysoidine citrate hydrochloride
525
81
178
Cinchocaine (INN) and its salts
120
129
179
Cincophen (INN), its salts and derivatives and salts of those derivatives
539
8
180
Claviceps purpurea Tul., its alkaloids and galenical preparations
296
98
181
Clofenamide (INN)
154
85
182
Clofenotane (INN)
213, 676
123
183
Cobalt benzenesulphonate
—
101
184
Cocculin
551
282
185
Colchicine, its salts and derivatives
—
102
186
Colchicoside and its derivatives
—
103
187
Colchicum autumnale L. and its galenical preparations
—
104
188
Colouring agent CI 12140
—
378
189
Colouring agent CI 26105
—
379
190
Colouring agents CI 42555, 42555–1 and 42555–2
—
380
191
Coniferyl benzoate (except natural content of essences)
84
357
192
Coniine
574
290
193
Conium maculatum L. (fruit, powder, galenical preparations)
—
99
194
Convallatoxin
—
105
195
Coumetarol (INN)
427
225
196
Crimidine (ISO)
152, 157
83
197
Croton tiglium(oil)
—
107
198
Curare and curarine
—
109
199
Curarizants, synthetic
—
110
200
Cyanides
363, 365
111
201
1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester hydrochloride
277
80
202
Cyclarbamate (INN)
210
122
203
Cyclizine (INN) and its salts
282
159
204
Cyclobarbitone and its salts
(68)
220
205
Cyclocoumarol
245
234
206
2-α-Cyclohexylbenzyl(N,N,N',N'-tetraethyl)trimethylenediamine
517
112
207
2-Cyclohexyl-3,5-dimethylphenol and its salts
209
113
208
1-Cyclohexyl-3-(p-methylbenzenesulphonyl)urea
340
100
209
Cyclomenol (INN) and its salts
207
113
210
Cyclopentane-1,1-dimethanol dicarbanilate
202
122
211
Cyclophosphamide (INN) and its salts
99, 102
88
212
Datura stramonium L. and its galenical preparations
601
301
213
DDT (ISO) (p,p'-DDT)
182, 676
123
214
Deanol aceglumate (INN)
256
3
215
Decamethonium bromide (INN)
216
214
216
Decamethylenebis(trimethylammonium) salts
215
214
217
Dextromethorphan (INN) and its salts
430
226
218
Dextropropoxyphene (INN)
260
116
219
O,O'-Diacetyl-N-allyl—N-normorphine
—
117
220
1,2-Diaminobenzene and its salts
533
363
221
p,p'-Diaminodiphenyl
79
26
222
1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
395
148
223
5-(α, β-Dibromophenethyl)-5-methylhydantoin
—
119
224
Dibromosalicylanilides
225, 416
351
225
Dibromsalan (INN)
(224)
351
226
Dichloroethanes
306, 309
125
227
Dichloroethylenes
7, 702
126
228
2,3-Dichloro-2-methylbutane
46
36
229
Dichlorosalicylanilides
—
349
230
Dicoumarin
231, 440
231
231
Dicoumarol (INN)
230, 440
231
232
2-(Diethylaminoethoxy)ethyl α-phenylpiperidine-1-acetate dimethiodide
560
137
233
1-[4-(β-Diethylaminoethoxy)phenyl]-1-(4-tolyl)-2-(4-chlorophenyl)-ethanol
691
92
234
2-Diethylaminoethyl 3-amino-4-butoxybenzoate and its salts
27, 95
23
235
2-Diethylaminoethyl benzilate and its salts
71
157
236
2-Diethylaminoethyl 4-ethoxybenzoate and its salts
383, 500
179
237
2-Diethylaminoethyl 3-hydroxy-4-phenylbenzoate and its salts
—
128
238
2-Diethylaminoethyl α-phenyl-α-(N-piperidino)acetate
97
287
239
3-Diethylaminopropyl cinnamate
—
130
240
Diethyl 4-nitrophenyl phosphate
498
170
241
O,O-DiethylO-4-nitrophenyl phosphorothioate
499
131
242
Difencloxazine (INN)
529
270
243
Digitaline and all heterosides ofDigitalis purpurea L.
—
134
244
4,5-Dihydrobenzimidazol-4-one
82, 83
48
245
3,4-Dihydro-2-methoxy-2-methyl-4-phenyl-2H, 5H-pyrano [3,2—c]-[1]-benzopyran-5-one
205
234
246
Dihydrotachysterol (INN)
—
342
247
2,2'-Dihydroxy-3,3',5,5'6,6'-hexachlorodiphenylmethane (hexachlorophene)
351
371
248
3,4-Dihydroxy-α-(isopropylaminomethyl)benzyl alcohol
391, 394
17
249
3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol
14, 294
14
250
4,4'-Dihydroxy-3,3'-(3-methylthiopropylidene)dicoumarin
—
207
251
1-(3,4-Dihydroxyphenyl)-2-ethylaminopropan-1-ol
274
136
252
5,5'-Di-isopropyl-2,2'-dimethylbiphenyl-4,4'-diyl dihypoiodite
385
361
253
Dimethoxane
265
368
254
4-[β-(3,4-Dimethoxyphenyl)ethyl]-1-(2-chlorophenyl)piperazine and its salts
411
141
255
Dimethylamine
—
142
256
2-DimethylaminoethylN-acetylglutamate
214
3
257
2-[α-(2-Dimethylaminoethoxy)-α-methylbenzyl]pyridine and its salts
290
176
258
2-Dimethylaminoethylp-butylaminobenzoate and its salts
634
63
259
2-[(2-Dimethylaminoethyl)-2-thienylamino]pyridine and its salts
421
144
260
(+)-4-Dimethylamino-3-methyl-1,2-diphenyl-2-propionyloxybutane
218
116
261
1-Dimethylaminomethyl-1-methylpropyl benzoate and its salts
50
50
262
2-Dimethylaminopropiophenone and its salts
418
145
263
3-(3-Dimethylaminopropylidene)-1,2:4,5-dibenzocyclohepta-1,4-diene and its salts
42
146
264
N,N-Dimethyldiguanide and its salts
420
147
265
2,6-Dimethyl-1,3-dioxan-4-yl acetate (Dimethoxane)
253
368
266
Dimethylformamide
—
355
267
1,3-Dimethylpentylamine and its salts
36, 442
30
268
1,2-Dimethyl-4-phenyl-4-carbmethoxyhexamethyleneimine and its salts
422
174
269
1,3-Dimethyl-4-phenyl-4-carboxyethylhexamethyleneimine and its salts
419
171
270
Dimethyl sulphoxide (INN)
—
338
271
Dimevamide (INN) and its salts
278
153
272
Dinitrophenol isomers
—
151
273
Dioxane
—
343
274
Dioxethedrin (INN) and its salts
251
136
275
2,5-Dioxo-3,3-diethyl-5-methylpiperidine and its salts
452
133
276
Diphenhydramine (INN) and its salts
78
339
277
Diphenoxylate hydrochloride (INNM)
201
80
278
2,2-Diphenyl-4-dimethylamino-valeramide and its salts
271
153
279
5,5-Diphenyl-4-imidazolidone
—
160
280
4-Diphenylmethoxy-1-methylpiperidine and its salts
286
154
281
3-Diphenylmethoxytropane and its salts
75
158
282
1-Diphenylmethyl-4-methylpiperazine
203
159
283
1,2-Diphenyl-4-(2-phenylsulphinylethyl)pyrazolidine-3,5-dione
608
155
284
α,α-Diphenyl-2-piperidinemethanol
559
285
285
α,α-Diphenyl-4-piperidinemethanol
65
286
286
Diphenylpyraline (INN) and its salts
280
154
287
2,5-Dipropoxy-3,6-bis(ethyleneimino)-1,4-benzoquinone
382
152
288
4-Dipropylsulphamylbenzoic acid
565
161
289
Disulfiram (INN)
645, 656
162
290
Doxylamine (INN) and its salts
257
176
291
Emetine, its salts and derivatives
—
163
292
Endrin (ISO)
349
196
293
Ephedrine and its salts
—
164
294
Epinephrine (INN)
14, 249
14
295
Ergocalciferol (INN)
(703)
335
296
Ergot, its alkaloids and galenical preparations
180
98
297
Eserine and its salts
548
166
298
Ethionamide (INN)
310
319
299
Ethoheptazine (INN) and its salts
446
173
300
Ethopropazine and its salts
(521)
320
301
4-Ethoxyphenol
(366, 456)
178
302
2-Ethylamino-5-phenyloxazolin-4-one
319
180
303
Ethyl bis(4-hydroxycoumarinyl)-acetate and salts of the acid
304
204
304
Ethyl bis(4-hydroxy-2-oxo-1-benzopyran-3-yl)acetate and salts of the acid
303
204
305
Ethyl chloride
155
96
306
Ethylene dichloride
(226)
125
307
Ethylene oxide
—
182
308
2-Ethyl-2,3-epoxyhexamide and its derivatives
493
165
309
Ethylidene chloride
(226)
125
310
3-Ethylisothionicotinamide
298
319
311
β-Ethyl-β-methylglutarimide and its salts
70, 312
183
312
4-Ethyl-4-methylpiperidine-2,6-dione and its salts
70, 311
183
313
β-Ethyl-β-methylvaleramide
698
184
314
Ethylphenacemide (INN)
528
272
315
2-Ethyl-2-phenylglutarimide and its salts
316, 338
181
316
3-Ethyl-3-phenylpiperidine-2,6-dione and its salts
315, 338
181
317
3'-Ethyl-5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-acetonaphthone
9
362
318
Fenadiazole (INN)
374
208
319
Fenozolone (INN)
302
180
320
Fenyramidol (INN)
538, 541
274
321
Fluanisone (INN)
326
187
322
Fluoresone (INN)
325
189
323
4'-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro—m-tolyl)piperidino]-butyrophenone
685
188
324
6-Fluoro-16-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione
497
186
325
p-Fluorophenylethylsulphone
322
189
326
1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-butan-1-one
321
187
327
5-Fluoropyrimidine-2,4-dione
328
190
328
Fluorouracil (INN)
327
190
329
Fluphenazine (INN)
(521)
320
330
Furazolidone (INN)
479
252
331
Furfuryltrimethylammonium salts
334
192
332
Furo[3,2—g]chromen-7-one and its alkyl-substituted derivatives (except natural content of essences)
333, 434, 690
358
333
Furocoumarin and its alkyl-substituted derivatives (except natural content of essences)
332, 434, 690
358
334
Furtrethonium iodide (INN)
331
192
335
Galantamine (INN)
—
193
336
Gallamine triethiodide (INN)
693
329
337
Glucocorticoids
94
300
338
Glutethimide (INN) and its salts
315, 316
181
339
Glycerol trinitrate
480, 571
253
340
Glycyclamide (INN)
208
100
341
Gold salts
—
296
342
Guaifenesin (INN)
432
230
343
Guanethidine (INN) and its salts
344
259
344
N-(2-Guanidinoethyl)heptamethyleneimine and its salts
343
259
345
Haloperidol (INN)
160
185
346
HCH (ISO) (gamma-HCH)
96, 348, 401
195
347
HETP
353
316
348
1,2,3,4,5,6-Hexachlorocyclohexane
96, 346, 401
195
349
(1R, 4S, 5R, 8S)-1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4:5,8-dimethanonaphthalene
292
196
350
Hexachloroethane
—
197
351
Hexachlorophene (INN)
247
371
352
(1R,4S,5R,8S)-1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethanonaphthalene
388
198
353
Hexaethyl tetraphosphate
347
316
354
(1R,2S)-Hexahydro-1,2-dimethyl-3,6-epoxyphthalic anhydride
131
70
355
(3S,5aR,9bS)-3,3a,4,5,5a,9b-Hexahydro-3,5a,9-trimethylnaphtho-[1,2-b]furan-2,8-dione
587
217
356
Hexamethonium bromide (INN)
(357)
124
357
N,N'-Hexamethylenebis(trimethylammonium) salts
356
124
358
Hexapropymate (INN)
575
115
359
Hydrastine, hydrastinine and their salts
—
199
360
Hydrazides and their salts
—
200
361
Hydrazine, its derivatives and their salts
—
201
362
2-Hydrazino-octane and its salts
487
202
363
Hydrocyanic acid and its salts
200, 365
111
364
Hydrofluoric acid, its normal salts, complexes and hydrofluorides (except those listed in Part I of Schedule 2)
—
191
365
Hydrogen cyanide and its salts
200, 363
111
366
Hydroquinone monobenzyl, monoethyl and monomethyl ethers
91, 301, 431, (456)
178
367
7-[2-Hydroxy-3-(2-hydroxyethyl—N-methylamino)propyl]theophylline
706
135
368
[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid and its salts
686
5
369
3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propionic acid and its salts
659
9
370
1-Hydroxymethyl-1-cyclohexylacetic acid, sodium salt
593
114
371
8-Hydroxy-5(or 6)-nitroquinoline and its salts
482
209
372
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-coumarin and its salts
2, 704
203
373
1-(4-Hydroxy-β-phenylethyl)-4-phenyl-4-carbethoxypiperidine and its salts
495
172
374
2-(4-Hydroxyphenyl-1,3,4-oxadiazole
318
208
375
1-Hydroxy-2,4,6-trinitrobenzene
550, 689
268
376
Hydroxyzine (INN)
159
240
377
Hyoscine, its salts and derivatives
590
295
378
Hyoscyamine, its salts and derivatives
—
210
379
Hyoscyamus niger L(leaves, seeds powder and galenical preparations)
—
211
380
2-Imino-5-phenyloxazolidin-4-one and its salts
502
212
381
Imperatorin
437
34
382
Inproquone (INN)
287
152
383
Intracaine and its salts
236, 500
179
384
Iodine
—
213
385
Iodothymol
252
361
386
Ipecacuanha (Cephaelis ipecacuanha Brot. and related species) (roots, powder and galenical preparations)
—
215
387
Isocarboxazid (INN)
88
52
388
Isodrin
352
198
389
Isometheptene (INN) and its salts
435
228
390
2-Isooctylamine and its salts
35, 489
28
391
Isoprenaline (INN)
248, 394
17
392
Isopropamide iodide (INN)
135
156
393
(2-Isopropylpent-4-enoyl)urea
59
216
394
Isoproterenol
248, 391
17
395
Isosorbide dinitrate (INN)
222
148
396
Juniperus sabina L. (leaves, essential oil and galenical preparations)
—
294
397
Laurel oil
398
359
398
Laurus nobilis L. (oil from seeds)
397
359
399
Lead and its compounds (except lead acetate)
—
289
400
Levophacetoperane and its salts
556
284
401
Lindane
96, 346, 348
195
402
Lobelia inflata L. and its galenical preparations
—
218
403
Lobeline (INN) and its salts
105
219
404
LSD
406, 407
127
405
Lupinidine and its salts
598
299
406
Lysergic acid diethylamide and its salts
404, 407
127
407
Lysergide (INN) and its salts
404, 406
127
408
Malononitrile
—
149
409
Mannomustine (INN) and its salts
98
89
410
Mecamylamine (INN)
644
229
411
Mefeclorazine (INN) and its salts
254
141
412
Mephenesin (INN) and its esters
664
322
413
Meprobamate (INN)
450
236
414
Mercury and its compounds (except those listed in Part III of Schedule 2 or in Part I of Schedule 4)
—
221
415
Mescaline and its salts
687
222
416
Metabromsalan (INN)
(224)
351
417
Metaldehyde
562
223
418
Metamfepramone (INN) and its salts
262
145
419
Metethoheptazine (INN) and its salts
269
171
420
Metformin (INN) and its salts
264
147
421
Methapyrilene (INN) and its salts
259
144
422
Metheptazine (INN) and its salts
268
174
423
Methocarbamol (INN)
433
205
424
Methohexitone and its salts
(68)
220
425
Methotrexate (INN)
34
6
426
2-[4-Methoxybenzyl—N-(2-pyridyl)amino]ethyldimethylamine maleate
580
346
427
1-Methoxy-2,2-bis(4-hydroxy-3-coumarinyl)ethane
195
225
428
1-Methoxy-2,4-diaminobenzene (2,4-diaminoanisole-CI 76050)
—
376
429
1-Methoxy-2,5 diaminobenzene (2,5-diaminoanisole)
—
377
430
(+)-3-Methoxy—N-methylmorphinan and its salts
217
226
431
4-Methoxyphenol
(366, 456)
178
432
3-(4-Methoxyphenoxy)propane-1,2-diol
342
230
433
3-(2-Methoxyphenoxy)propane-1,2-diol 1-carbamate
423
205
434
8-Methoxypsoralen (except natural content of essences)
332, 333, 690
358
435
6-Methylamino-2-methylhept-2-ene and its salts
389
228
436
2-Methyl-1,2-bis(3-pyridyl)-propan-1-one
453
292
437
9-(3-Methylbut-2-enyloxy)furo-[3,2—g]chromen-7-one
381
34
438
2-Methyl-6-chloroanilide of n-butylaminoacetic acid and its salts
117
90
439
1-Methyl-2,4-diaminobenzene and its salts
447
364
440
3,3-Methylenebis-(4-hydroxycoumarin)
230, 231
231
441
2-Methylheptylamine and its salts
—
227
442
4-Methyl-2-hexylamine and its salts
36, 267
30
443
N,N'-[(Methylimino)diethylene]bis-(ethyldimethylammonium) salts
66
121
444
1-Methyl-2-mercaptoimidazole
650
233
445
Methylphenidate (INN) and its salts
535
175
446
1-Methyl-4-phenyl-4-carbethoxyhexamethyleneimine and its salts
299
173
447
4-Methyl—m-phenylenediamine and its salts
439
364
448
3-Methyl-2-phenylmorpholine, its derivatives and salts
519
232
449
2-Methyl-2-propyl-1-isopropylcarbamoyloxy-3-carbamoyloxypropane
141
235
450
2-Methyl-2-propylpropane-1,3-diol dicarbamate
413
236
451
N-Methyl-1,2,5,6-tetrahydro-3-nicotinic acid methyl ester
60
238
452
Methyprylon (INN) and its salts
275
133
453
Metyrapone (INN)
436
292
454
Minoxidil (INN), its salts and derivatives
558
372
455
Mofebutazone (INN)
124
64
456
Monobenzone (INN)
91, 301, (366) 431
178
457
Morpholine and its salts
—
344
458
Mustine and its salts
100, 148
87
459
MustineN-oxide and its salts
101
86
460
Nalorphine (INN), its salts and ethers
21
20
461
Naphazoline (INN) and its salts
467
244
462
2-Naphthol
463
241
463
β-Naphthol
462
241
464
1-and 2-Naphthylamines and their salts
465
242
465
α-and β-Naphthylamines and their salts
464
242
466
3-(1-Naphthyl)-4-hydroxycoumarin
—
243
467
2-(1-Naphthylmethyl)imidazoline and its salts
461
244
468
Narcotics, natural and synthetic: All substances listed in Tables I and II of the Single Convention on Narcotic Drugs 1961 (Treaty Series No. 34(1965), Cmnd. 2631)
—
306
469
Narcotine and its salts
485
258
470
Neodymium and its salts
—
309
471
Neostigmine and its salts
—
245
472
Nicotine and its salts
—
246
473
Nitrites, inorganic (except sodium nitrite)
—
248
474
Nitrobenzene
—
249
475
Nitrocresols and their alkali metal salts
—
250
476
Nitroderivatives of carbazole
136
72
477
Nitrofurantoin (INN)
478
251
478
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin
477
251
479
3-(5-Nitrofurfurylideneamino)-oxazolidin-2-one
330
252
480
Nitroglycerine
339, 571
253
481
Nitrostilbenes, their homologues and derivatives
—
256
482
Nitroxoline (INN) and its salts
371
209
483
Noradrenaline and its salts
33, 484
257
484
Norepinephrine and its salts
33, 483
257
485
Noscapine (INN) and its salts
469
258
486
Nux vomica and its preparations
605
305
487
Octamoxin (INN) and its salts
362
202
488
Octamylamine (INN) and its salts
510
267
489
Octodrine (INN) and its salts
35, 390
28
490
Oestrogens
—
260
491
Oleandrin
—
261
492
[Oxalylbis(iminoethylene)]bis-[(o-chlorobenzyl)diethylammonium] salts
24
132
493
Oxanamide (INN) and its derivatives
308
165
494
2-Oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo-[a]quinolizine and its salts
632
139
495
Oxpheneridine (INN) and its salts
373
172
496
Padimate A
47
381
497
Paramethasone (INN)
324
186
498
Paraoxon
240
170
499
Parathion (ISO)
241
131
500
Parethoxycaine (INN) and its salts
236, 383
179
501
Pelletierine and its salts
557
263
502
Pemoline (INN) and its salts
380
212
503
Pentachloroethane
—
264
504
Pentaerythritol chloral
514
266
505
Pentaerythritol tetranitrate
506, 513
265
506
Pentaerythrityl tetranitrate (INN)
505, 513
265
507
Pentamethonium bromide (INN)
508
120
508
N,N'-Pentamethylenebis-(trimethylammonium) salts
507
120
509
Pentobarbitone and its salts
68
220
510
Pentylaminomethylheptane, its isomers and salts
488
267
511
Perchloroethylene
636
314
512
Perphenazine (INN) and its salts
(521)
320
513
PETN
505, 506
265
514
Petrichloral (INN)
504
266
515
Phenacemide (INN)
524
269
516
Phenaglycodol (INN)
161
95
517
Phenetamine
206
112
518
Phenindone (INN)
534
271
519
Phenmetrazine (INN), its derivatives and salts
448
232
520
Phenobarbitone and its salts
(68)
220
521
Phenothiazine (INN) and its compounds
various
320
522
Phenprobamate (INN)
536
71
523
Phenprocoumon (INN)
537
273
524
N-Phenylacetylurea
515
269
525
4-Phenylazophenylene-1,3-diamine citrate hydrochloride
177
81
526
Phenylbutazone (INN)
123
67
527
4-Phenylbut-3-en-2-one
89
356
528
N-(2-Phenylbutyryl)urea
314
272
529
N-[2-(α-Phenyl—p-chlorobenzyl)-ethyl]morpholine
242
270
530
1-Phenylcyclopentanecarboxylic acid diethylaminoethyl ester and its salts
134
169
531
2-Phenylcyclopropylamine (trans-form) and its salts
665, 666
324
532
1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one
576
138
533
o-Phenylenediamine and its salts
220
363
534
2-Phenylindan-1,3-dione
518
271
535
α-Phenyl-2-piperidineacetic acid methyl ester and its salts
445
175
536
1-Phenylpropan-1-ol carbamate
522
71
537
3-(α-Phenylpropyl)-4-hydroxycoumarin
523
273
538
1-Phenyl-2-(2-pyridylamino)ethanol
320, 541
274
539
2-Phenylquinoline-4-carboxylic acid, its saltsand derivatives and salts of those derivatives
179
8
540
6-Phenyl-2,4,7-triaminopteridine and its salts
669
275
541
Phenyramidol
320, 538
274
542
Phosphides, metal
543
279
543
Phosphorus
542
279
544
4-Phosphoryloxy—N,N-dimethyl-tryptamine
578
278
545
3-Phthalimidopiperidine-2,6-dione and its salts
647
280
546
Phthalylsulphathiazole (INN) and its salts
(622)
307
547
Physostigma venenosum Balf.
129
281
548
Physostigmine and its salts
297
166
549
Phytolacca Spp and their preparations
—
374
550
Picric acid
375, 689
268
551
Picrotoxin
184
282
552
Pilocarpine and its salts
—
283
553
Pilocarpus jaborandi Holmes and its galenical preparations
—
311
554
Pipazetate (INN) and its salts
555
118
555
2-(2-Piperidinoethoxy)ethyl-10-thia-1,9-diazaanthracene-9-carboxylate and its salts
554
118
556
α-Piperidin-2-ylbenzyl acetate, laevorotatorythreo-form
400
284
557
β-(2-Piperidyl)propionaldehyde and its salts
501
263
558
6-(Piperidinyl)-2,4-pyrimidinediamine-3-oxide (Minoxidil) and its salts and derivatives
454
372
559
Pipradrol (INN) and its salts
284
285
560
Piprocurarium iodide (INN)
232
137
561
Poldine metilsulfate (INN) (or methylsulphate)
81
239
562
Polyacetaldehyde
417
223
563
Potassium nitroferricyanide
15, 564, 594–5
255
564
Potassium nitroprusside
15, 563, 594–5
255
565
Probenecid (INN)
288
161
566
Procainamide (INN), its salts and derivatives
30
25
567
Prochlorperazine (INN) and its salts
(521)
320
568
Progestogens (except progesterone and ethisterone)
—
194
569
Promazine (INN) and its salts
(521)
320
570
Promethazine (INN) and its salts
(521)
320
571
Propane-1,2,3-triyl trinitrate
339, 480
253
572
Propatylnitrate (INN)
104
206
573
1-Propyl-3-(4-chlorobenzene-sulphonyl)urea
169
79
574
2-Propylpiperidine
192
290
575
1-(2-Propynyl)cyclohexyl carbamate
358
115
576
Propyphenazone (INN)
532
138
577
Prunus laurocerasus L.
145
291
578
Psilocybine (INN)
544
278
579
Pyrethrum album L. and its galenical preparations
—
345
580
Pyrianisamine maleate
426
346
581
Pyribenzamine
92, 692
347
582
Pyrithione sodium (INNM)
—
369
583
Quinalbarbitone and its salts
(68)
220
584
Radioactive substances (except substances which are radioactive naturally or by reason of contamination from the environment, which have not been enriched for manufacturing purposes, and of which the concentration complies with Council Directive No. 76/579/Euratom)
—
293
585
Rauwolfia serpentina alkaloids and their salts
586
15
586
Reserpine (INN) and its salts
(585)
15
587
α-Santonin
355
217
588
Safrole (except natural content of essences in cases where the concentration of such safrole in the cosmetic product does not exceed–
(a) in the case of oral hygiene or dental products other than toothpaste intended specifically for children, 50 ppm; or
(b) in the case of products other than oral hygiene or dental products, 100 ppm.)
—
360
589
Schoenocaulon officinale Lind.(seeds and galenical preparations)
—
332
590
Scopolamine, its salts and derivatives
377
295
591
Secbutobarbitone and its salts
(68)
220
592
Selenium and its compounds except when permitted under the restrictions laid down in Part I of Schedule 2
—
297
593
Sodium hexacyclonate (INN)
370
114
594
Sodium nitroferricyanide
15, 563, 564, 595
255
595
Sodium nitroprusside
15, 563, 564,594
255
596
Solanum nigrum L. and its galenical preparations
—
298
597
Spanish Fly
130
69
598
Sparteine (INN) and its salts
405
299
599
Spironolactone (INN)
10
4
600
Squill and its preparations
696
330
601
Stramonium and its preparations
212
301
602
Strophanthines and their aglucones and their respective derivatives
—
302
603
Strophanthus species and their galenical preparations
—
303
604
Strychnine and its salts
—
304
605
Strychnos species and their galenical preparations
486
305
606
Succinonitrile
—
150
607
Succinylsulphathiazole and its salts
(622)
307
608
Sulfinpyrazone (INN)
283
155
609
Sulphacetamide and its salts
(622)
307
610
Sulphadiazine and its salts
(622)
307
611
Sulphadimethoxine and its salts
(622)
307
612
Sulphadimidine and its salts
(622)
307
613
Sulphafurazole and its salts
(622)
307
614
Sulphaguanidine and its salts
(622)
307
615
Sulphamethizole and its salts
(622)
307
616
Sulphamethoxazole and its salts
(622)
307
617
Sulphamethoxydiazine and its salts
(622)
307
618
Sulphamethoxypyridazine and its salts
(622)
307
619
Sulphanilamide and its salts
(622)
307
620
Sulphapyridine and its salts
(622)
307
621
Sulphathiazole and its salts
(622)
307
622
Sulphonamides (sulphanilamide and its derivatives obtained by substitution of one or more H-atoms of the —NH2 groups) and their salts
various
307
623
Sulthiame
624, 643
308
624
Sultiame (INN)
623, 643
308
625
Sympathomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and are referred to in resolution AP (69) 2 of the Council of Europe
44
21
626
Tefazoline (INN) and its salts
642
237
627
Tellurium and its compounds
—
312
628
TEPP (ISO)
640
276
629
2-(4—tert-Butyl-2,6-dimethylbenzyl)-imidazoline and its salts
708
313
630
4—tert-Butylphenol
—
340
631
4—tert-butylpyrocatechol
—
341
632
Tetrabenazine (INN) and its salts
494
139
633
Tetrabromosalicylanilides
—
350
634
Tetracaine (INN) and its salts
258
63
635
2,3,7,8-Tetrachlorodibenzo—p-dioxin
—
367
636
Tetrachloroethylene
511
314
637
Tetrachloromethane
138
315
638
Tetrachlorosalicylanilides
—
348
639
Tetraethylammonium bromide
646
61
640
Tetraethyl pyrophosphate
628
276
641
5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-dihydric alcohol and its salts
58
42
642
2-(5,6,7,8-Tetrahydro-1-methyl-2-naphthyl)-2-imidazoline and its salts
626
237
643
4-(Tetrahydro-2H-1,2-thiazin-2-yl)-benzenesulphonamideS,S-dioxide
623, 624
308
644
N,2,3,3-Tetramethyl-2-norcamphanamine
410
229
645
Tetramethylthiuam disulphide
289, 656
162
646
Tetrylammonium bromide (INN)
639
61
647
Thalidomide (INN) and its salts
545
280
648
Thallium and its compounds
—
317
649
Thevetia neriifolia Juss., glycoside extract
—
318
650
Thiamazole (INN)
444
233
651
2,2'-Thiobis(4,6-dichlorophenol)
106
352
652
Thiopentone and its salts
(68)
220
653
Thioridazine (INN) and its salts
(521)
320
654
Thiotepa (INN)
670, 683
310
655
Thiourea and its derivatives (except the one listed in Part I of Schedule 2)
—
321
656
Thiram (ISO)
289, 645
162
657
Thiuram disulphides
—
354
658
Thiuram monosulphides
—
353
659
Thyropropic acid (INN) and its salts
369
9
660
Tolboxane (INN)
663
177
661
Tolbutamide (INN)
125
65
662
Toluidines, their isomers, salts and halogenated and sulphonated derivatives
40
32
663
p-Tolylboric acid ester of 2-methyl-2-propylpropane-1,3-diol
660
177
664
3—o-Tolyloxypropane-1,2-diol
412
322
665
trans-2-Phenylcyclopropylamine and its salts
531, 666
324
666
Tranylcypromine (INN) and its salts
531, 665
324
667
Tretamine (INN)
682
328
668
Tretinoin (INN) (retinoic acid and its salts)
—
375
669
Triamterene (INN) and its salts
540
275
670
Triaziridin-1-ylphosphine sulphide
654, 683
310
671
2,2,2-Tribromoethanol
672
326
672
Tribromoethyl alcohol
671
326
673
3,4,5-Tribromosalicylanilide (Tribromsalan)
—
373
674
Trichlormethine (INN) and its salts
678
327
675
Trichloroacetic acid
—
10
676
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane
182, 213
123
677
2,2,2-Trichloroethane-1,1-diol
146
77
678
Tri(β-chloroethyl)amine and its salts
674
327
679
Trichloromethane
156
366
680
N-(Trichloromethylthio)-4-cyclohex-4-ene-1,2-dicarboximide (Captan)
132
370
681
Tricresyl phosphate
694
277
682
2,4,6-Triethyleneimino-1,3,5-triazine
667
328
683
N,N,N-Triethylenethiophosphamide
654, 670
310
684
Trifluoperazine (INN) and its salts
(521)
320
685
Trifluperidol (INN)
323
188
686
3,3',5-Triiodothyroacetic acid and its salts
368
5
687
3,4,5-Trimethoxyphenethylamine and its salts
415
222
688
2-2-6-Trimethyl-4-piperidyl benzoate and its salts
74
51
689
2,4,6-Trinitrophenol
375, 550
268
690
Trioxysalan (INN) (except natural content ofessences)
332, 333, 434
358
691
Triparanol (INN)
233
92
692
Tripelennamine (INN)
92, 581
347
693
1,2,3-Tris(2-triethylammonium-ethoxy)benzene triiodide
336
329
694
Tritolyl phosphate
681
277
695
Tuaminoheptane (INN), its isomers and salts
31
27
696
Urginea scilla Stern. and its galenical preparations
600
330
697
Vaccines, toxins and serums listed in the Annex to Council Directive No. 75/319/EEC
—
323
698
Valnoctamide (INN)
313
184
699
Veratrine, its salts and galenical preparations
—
331
700
Veratrum spp and their preparations
—
333
701
Vinyl chloride monomer
—
334
702
Vinylidene chloride
7, 227
126
703
Vitamins D2 and D3
174, 295
335
704
Warfarin (ISO) and its salts
2,372
203
705
Xanthates
16
336
706
Xanthinol
367
135
707
Xylidines, their isomers, salts and halogenated and sulphonated derivatives
41
33
708
Xylometazoline (INN) and its salts
629
313
709
Yohimbine and its salts
—
337
710
Zoxazolamine (INN)
29
24

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Source: https://www.legislation.gov.uk/uksi/1989/2233/schedule/1 (the official version)
Page: https://openlegislation.uk/cosmetic-products-safety-regulations-1989/schedule-1
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.