# The Cosmetic Products (Safety) Regulations 1989, Part I: substances listed in annex iii, part i of the directive as substances which cosmetic products must not contain except subject to the restrictions laid down (1) (2) (3) (4) (5) (6) Reference Number Name of substance Purpose of substance or type of product Maximum concentration of substance in product Other requirements Required information Combination Rules A. Where a cosmetic product contains two or more substances to which this Combination Rule applies, the concentration in the product of each of those substances shall be such that the sum of the relevant quotients for those substances (as defined in Rule C below) shall not exceed 1. B. Where a cosmetic product contains the substances to which this Combination Rule applies, the concentration in the product of each of those substances shall be such that the sum of the relevant quotients for those substances (as defined in Rule C below) shall not exceed 2; but the concentration of each substance shall not in any event exceed the limit specified for the substance in respect of the product in column 4 above. C. The relevant quotient for each substance is the actual concentration of the substance in the product divided by the maximum concentration specified for the substance in respect of the product in Column 4 of this Schedule. 1 Boric acid Talcum powder 5 per cent Not to be used in products intended for children less than three years old Not to be used for children under three years of age Oral hygiene products 0.5 per cent — — Other products 3 per cent — — 2 (a) Thioglycollic acid, its salts and esters Hair waving or straightening products for general use 8 per cent (calculated as thioglycollic acid) ready for use pH value 7 to 9.5 Contains thioglycollate. Follow the instructions. Keep out of reach of children. For professional use only (where applicable) Hair waving or straightening products for professional use 11 per cent (calculated as thioglycollic acid) ready for use pH value 7 to 9.5 Depilatories 5 per cent (calculated as thioglycollic acid) ready for use pH value 7 to 12.7 Other hair care products which are removed after application 2 per cent (calculated as thioglycollic acid) ready for use pH value 7 to 9.5 The directions for use drawn up in national or official languages must incorporate the following instructions—Avoid contact with eyes. In the event of contact with the eyes rinse immediately with plenty of water and seek medical advice. Wear suitable gloves (this latter instruction does not apply to Depilatories) (b) Thioglycollic acid esters Hair waving or straightening products for general use 8 per cent (calculated as thioglycollic acid) ready for use pH value 6 to 9.5 Hair waving or straightening products for professional use 11 per cent (calculated as thioglycollic acid) ready for use pH value 6 to 9.5 The directions for use drawn up in national or official languages must incorporate the following instructions—May cause sensitisation in the event of contact with the skin. Avoid contact with eyes. In the event of contact with the eyes rinse immediately with plenty of water and seek medical advice. Wear suitable gloves 3 Oxalic acid, its esters and alkaline salts Hair care products 5 per cent — For professional use only 4 Ammonia All purposes and products 6 per cent calculated as NH3 — Contains ammonia (not required when concentration is not more than 2 per cent) 5 Tosylchloramide Sodium All purposes and products 0.2 per cent — — 6 Chlorates of alkali metals Toothpaste 5 per cent — — Other uses 3 per cent — — 7 Dichloromethane All purposes and products 35 per cent (and when mixed with 1,1,1-trichloroethane, total concentration must not exceed 35 per cent) Purity of the dichloromethane must be not less than 99.8 per cent — 8 m-andp-Phenylenediamines, theirN-substituted derivativesand their salts;N-substituted derivatives ofo-phenylenediamines Oxidizing colouring agents for hair dyeing for general use 6 per cent calculated as a free base, subject to the provisions of “Combination Rule A” set out below — Contains phenylenediamines. Can cause an allergic reaction. Sensitivity test advisable before use. Do not use to dye eyelashes or eyebrows Oxidizing colouring agents for hair dyeing for professional use 6 per cent calculated as a free base, subject to the provisions of “Combination Rule A” set out below — Contains phenylenediamines. For professional use only. Can cause an allergic reaction. Sensitivity test advisable before use 9 Methylphenylenediamines (other than 4-methyl—m-phenylenediamine and its salts), theirN-substituted derivatives and their salts Oxidizing colouring agents for hair dyeing for general use 10 per cent calculated as a free base, subject to the provisions of “Combination Rule A” set out below — Contains phenylenediamines. Can cause an allergic reaction. Sensitivity test advisable before use. Do not use to dye eyelashes or eyebrows Oxidizing colouring agents for hair dyeing for professional use 10 per cent calculated as a free base, subject to the provisions of “Combination Rule A” set out below — Contains phenylenediamines. For professional use only. Can cause an allergic reaction. Sensitivity test advisable before use 10 Diaminophenols Oxidizing colouring agents for hair dyeing for general use 10 per cent calculated as a free base, subject to the provisions of “Combination Rule A” set out below — Contains diaminophenols. Can cause an allergic reaction. Sensitivity test advisable before use. Do not use to dye eyelashes or eyebrows Oxidizing colouring agents for hair dyeing for professional use 10 per cent calculated as a free base, subject to the provisions of “Combination Rule A” set out below — Contains diaminophenols. For professional use only. Can cause allergic reaction. Sensitivity test advisable before use 11 Dichlorophen All purposes and products 0.5 per cent — Contains dichlorophen 12 Hydrogen peroxide Hair care products preparations 12 per cent of H2O2 (40 volumes) — Contains hydrogen peroxide. Avoid contact with eyes. Rinse eyes immediately if product comes into contact with them Skin hygiene preparations 4 per cent of H2O2 — Contains hydrogen peroxide. Avoid contact with eyes. Rinse eyes immediately if product comes into contact with them Nail hardening preparations 2 per cent of H2O2 — Contains hydrogen peroxide. Avoid contact with eyes. Rinse eyes immediately if product comes into contact with them 13 Formaldehyde (See also Part I of Schedule 4) Nail hardeners 5 per cent — Contains formaldehyde. Protect cuticles with grease or oil. (Not required when concentration is not more than 0.05 per cent) 14 Hydroquinone Oxidizing colouring agent for hair dyeing for general use 2 per cent subject to the provision of “Combination Rule B” set out below — Contains hydroquinone. Do not use to dye eyelashes or eyebrows. Rinse eyes immediately if product comes into contact with them Oxidizing colouring agent for hair dyeing for professional use 2 per cent subject to the provisions of “Combination Rule B” set out below — Contains hydroquinone. For professional use only. Rinse eyes immediately if product comes into contact with them Agents for localised skin lightener 2 per cent — Contains hydroquinone. Avoid contact with eyes. Apply to small areas. If irritation develops discontinue use. Do not use on children under the age of 12 15 Potassium and sodium hydroxide Nail cuticle solvent 5 per cent calculated as sodium hydroxide — Contains alkali. Avoid contact with eyes. Can cause blindness. Keep out of reach of children Hair straightener for general use 2 per cent calculated as sodium hydroxide — Contains alkali. Avoid contact with eyes. Can cause blindness. Keep out of reach of children Hair straightener for professional use 4.5 per cent calculated as sodium hydroxide — For professional use only. Avoid contact with eyes. Can cause blindness pH adjuster for depilatories — pH value not to exceed 12.7 Keep out of reach of children. Avoid contact with eyes Other uses as pH adjuster — pH value not to exceed 11 Keep out of reach of children. Avoid contact with eyes 16 α-Naphthol Colouring agent for hair dyeing 0.5 per cent — Contains α-naphthol 17 Sodium nitrite Rust inhibitor 0.2 per cent Do not use with secondary and/or tertiary amines or other substances forming nitrosamines — 18 Nitromethane Rust inhibitor 0.3 per cent — — 19 Phenol and its alkali salts Soaps and shampoos 1 per cent calculated as phenol — Contains phenol 20 Pyrogallol Oxidizing colouring agent for hair dyeing for general use 5 per cent subject to the provisions of “Combination Rule B” set out below — Contains pyrogallol. Do not use to dye eyelashes or eyebrows. Rinse eyes immediately if product comes into contact with them Oxidizing colouring agent for hair dyeing for professional use 5 per cent subject to the provisions of “Combination Rule B” set out below — Contains pyrogallol. For professional use only. Rinse eyes immediately if product comes into contact with them 21 Quinine and its salts Shampoos 0.5 per cent calculated as quinine base — — Hair lotions 0.2 per cent calculated as quinine base — — 22 Resorcinol Oxidizing colouring agent for hair dyeing for general use 5 per cent subject to the provisions of “Combination Rule B” set out below — Contains resorcinol. Rinse hair well after application. Do not use to dye eyelashes or eyebrows. Rinse eyes immediately if product comes into contact with them Oxidizing colouring agent for hair dyeing for professional use 5 per cent subject to the provisions of “Combination Rule B” set out below — Contains resorcinol. For professional use only. Rinse eyes immediately if product comes into contact with them Hair lotions and shampoos 0.5 per cent subject to the provisions of “Combination Rule B” set out below — Contains resorcinol 23 (a) Alkali sulphides Depilatories 2 per cent calculated as sulphur pH value not to exceed 12.7 Keep out of reach of children. Avoid contact with eyes (b) Alkaline earth sulphides Depilatories 6 per cent calculated as sulphur pH value not to exceed 12.7 Keep out of reach of children. Avoid contact with eyes 24 Water-soluble zinc salts with the exception of zinc 4-hydroxybenzenesulphonate All purposes and products 1 per cent calculated as zinc — — 25 Zinc 4-hydroxybenzenesulphonate Deodorants, antiperspirants and astringent lotions 6 per cent calculated as percentage of anhydrous substance — Avoid contact with eyes 26 Ammonium monofluorophosphate Oral hygiene products 0.15 per cent calculated as fluorine. When mixed with other fluorine compounds total fluorine concentration must not exceed 0.15 per cent — Contains ammonium monofluorophosphate 27 Sodium monofluorophosphate Oral hygiene products As for ammonium monofluorophosphate — Contains sodium monofluorophosphate 28 Potassium monofluorophosphate Oral hygiene products As for ammonium monofluorophosphate — Contains potassium monofluorophosphate 29 Calcium monofluorophosphate Oral hygiene products As for ammonium monofluorophosphate — Contains calcium monofluorophosphate 30 Calcium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains calcium fluoride 31 Sodium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains sodium fluoride 32 Potassium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains potassium fluoride 33 Ammonium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains ammonium fluoride 34 Aluminium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains aluminium fluoride 35 Stannous fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains stannous fluoride 36 Hexadecyl ammonium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains hexadecyl ammonium fluoride 37 3-(n-Hexadecyl-N-2-hydroxyethylammonio)propyl-bis(2-hydroxyethyl)ammonium difluoride Oral hygiene products As for ammonium monofluorophosphate — Contains 3-(n-hexadecyl-N-2-hydroxyethylammonio)propyl-bis(2-hydroxyethyl)ammonium difluoride 38 NN'N'-Tris(polyoxyethylene)—N-hexadecylpropylenediamine dihydrofluoride Oral hygiene products As for ammonium monofluorophosphate — ContainsNN'N'-tris(polyoxyethylene)—N-hexadecylpropylenediamine dihydrofluoride 39 Octadecenyl ammonium fluoride Oral hygiene products As for ammonium monofluorophosphate — Contains octadecenyl ammonium fluoride 40 Sodium fluorosilicate Oral hygiene products As for ammonium monofluorophosphate — Contains sodium fluorosilicate 41 Potassium fluorosilicate Oral hygiene products As for ammonium monofluorophosphate — Contains potassium fluorosilicate 42 Ammonium fluorosilicate Oral hygiene products As for ammonium monofluorophosphate — Contains ammonium fluorosilicate 43 Magnesium fluorosilicate Oral hygiene products As for ammonium monofluorophosphate — Contains magnesium fluorosilicate 44 1,3-Bis(hydroxymethyl)-imidazolidene-2-thione Hair care preparations 2 per cent Not to be used in aerosol dispensers Contains 1,3-Bis(hydroxymethyl)imidazoli-dene-2-thione Nail care preparations 2 per cent pH as applied value must be less than 4 Contains 1,3-Bis(hydroxymethyl)imidazoli-dene-2-thione 45 Benzyl alcohol (See also Part I of Schedule 4) Solvent, perfumes and flavourings — — — 46 6-Methylcoumarin Oral hygiene products 0.003 per cent — — 47 Nicomethanol hydrofluoride Oral hygiene products As for ammonium monofluorophosphate — Contains nicomethanol hydrofluoride 48 Silver nitrate Products to dye eyelashes or eyebrows 4 per cent — Contains silver nitrate. Rinse eyes immediately if product comes into contact with them 49 Selenium disulphide Anti-dandruff shampoos 1 per cent — Contains selenium disulphide. Avoid contact with eyes or damaged skin 50 Aluminium zirconium chloride hydroxide complexes AlxZr(OH)yCLz and the aluminium zirconium chloride hydroxide glycine complexes Anti-perspirants 20 per cent as anhydrous aluminium zirconium chloride hydroxide 5.4 per cent as zirconium The ratio of the number of aluminium atoms to that of zirconium atoms must be betweeen 2 and 10 The ratio of the number of (Al+Zr) atoms to chlorine atoms must be between 0.9 and 2.1 Not to be used in aerosol dispensers (sprays) Do not apply to irritated or damaged skin 51 Quinolin-8-ol and bis(8-hydroxy-quinolinium sulphate) (See also Part II of this Schedule) Stabilizer for hydrogen peroxide in rinse-off hair care preparations 0.3 per cent calculated as base — — Stabilizer for hydrogen peroxide in non-rinse-off hair care preparations 0.03 per cent calculated as base — — 52 Methanol Denaturant for ethanol and isopropyl alcohol 5 per cent calculated as a percentage of ethanol and isopropyl alcohol — — 53 Etidronic acid and its salts (1-hydroxy-ethylidene-diphosphonic acid and its salts) Hair care 1.5 per cent expressed as etidronic acid — — Soap 0.2 per cent expressed as etidronic acid — — 54 1-Phenoxypropan-2-ol (See also Part I of Schedule 4) Products rinsed off after use. Prohibited in oral hygiene products 2 per cent — — --- Source: https://www.legislation.gov.uk/uksi/1989/2233/schedule/2/part/I (the official version) Page: https://openlegislation.uk/cosmetic-products-safety-regulations-1989/schedule-2/part-I Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.