{
  "url": "https://openlegislation.uk/cosmetic-products-safety-regulations-2004/schedule-12/part-1",
  "json_url": "https://openlegislation.uk/cosmetic-products-safety-regulations-2004/schedule-12/part-1.json",
  "legislation": "uksi/2004/2152",
  "legislation_title": "The Cosmetic Products (Safety) Regulations 2004",
  "legislation_url": "https://openlegislation.uk/cosmetic-products-safety-regulations-2004",
  "path": "schedule/12/part/1",
  "kind": "part",
  "number": "1",
  "heading": null,
  "text": "Part 1 of this Schedule lists the alternative methods validated by the European Centre for the Validation of Alternative Methods (“ECVAM”) which are necessary to meet the requirements of these Regulations and which are listed in Annex V to Council Directive 67/548/EEC of 27th June 1967 on the approximation of laws, regulations and administrative provisions relating to classification, packaging and labelling of dangerous substances .\nThe reference number given in the second column of the table in Part 1 refers to the reference number under which the type of test is listed in Annex V to Directive 67/548/EEC.\nEntry Number\nReference Number\nType of Test (toxicological endpoint)\nAlternative Test Method\nDate after which this method is required to be used\n1\nB40\nSkin corrosion\nRat skin TER assay\n11.9.04\n2\nB40\nSkin corrosion\nHuman skin model assay\n11.9.04\n3\nB41\nPhototoxicity\nIn vitro 3T3 NRU phototoxicity test\n11.9.04",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "I",
      "label": "I1",
      "text": "Sch. 12 Pt. 1 in force at 11.9.2004, see reg. 1(1)"
    },
    {
      "type": "footnote",
      "label": "f1",
      "text": "O.J. l 196, 16.8.1967, p.1 as last amended by Directive 2004/73/EC (O.J. L152, 30.4.2004, p.1)"
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/uksi/2004/2152/schedule/12/part/1",
    "retrieved_at": "2026-10-29T05:20:02.092817+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}