# Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (notified under document number C(2002) 3044) (Text with EEA relevance) (2002/657/EC), Chapter 2.3.: CONFIRMATORY METHODS FOR ORGANIC RESIDUES AND CONTAMINANTS

Extent: E+W+S+N.I.

Confirmatory methods for organic residues or contaminants shall provide information on the chemical structure of the analyte. Consequently methods based only on chromatographic analysis without the use of spectrometric detection are not suitable on their own for use as confirmatory methods. However, if a single technique lacks sufficient specificity, the desired specificity shall be achieved by analytical procedures consisting of suitable combinations of clean-up, chromatographic separation(s) and spectrometric detection.
The following methods or method combinations are considered suitable for the identification of organic residues or contaminants for the substance groups indicated:
Table 1
Suitable confirmatory methods for organic residues or contaminants
Measuring technique
Substances Annex 1 96/23/EC
Limitations
LC or GC with mass-spectrometric detection
Groups A and B
Only if following either an on-line or an off-line chromatographic separation
Only if full scan techniques are used or using atleast3 (group B) or 4 (group A) identification points for techniques that do not record the full mass spectra
LC or GC with IR spectrometric detection
Groups A and B
Specific requirements for absorption in IR spectrometry have to be met
LC-full-scan DAD
Group B
Specific requirements for absorption in UV spectrometry have to be met
LC -fluorescence
Group B
Only for molecules that exhibit native fluorescence and to molecules that exhibit fluorescence after either transformation or derivatisation
2-D TLC - full-scan UV/VIS
Group B
Two-dimensional HPTLC and co-chromatography are mandatory
GC-Elektron capture detection
Group B
Only if two columns of different polarity are used
LC-immunogram
Group B
Only if at least two different chromatographic systems or a second, independent detection method are used
LC-UV/VIS (single wavelength)
Group B
Only if at least two different chromatographic systems or second, independent detection method are used.

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Source: https://www.legislation.gov.uk/eudn/2002/657/annex/chapter/2.3 (the official version)
Page: https://openlegislation.uk/eu-decision-2002-657/annex/chapter-2.3
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.