# Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results (notified under document number C(2002) 3044) (Text with EEA relevance) (2002/657/EC), Division 3.1.1.2: Trueness

Extent: E+W+S+N.I.

In this paragraph, the determination of trueness (one component of accuracy) is described. Trueness can only be established by means of certified reference material (CRM). A CRM be used whenever available. The procedure is described in detail in ISO 5725-4 (5). An example is given below:
analyse six replicates of the CRM in accordance with the test instructions for the method,
determine the concentration of the analyte present in each sample of the replicates,
calculate the mean, the standard deviation and the coefficient of variation (%) for these concentrations,
calculate the trueness by dividing the detected mean concentration by the certified value (measured as concentration) and multiply by 100, to express the result as a percentage.
Trueness ( %) = mean recovery-corrected concentration detected × 100/certified value.
If no CRM is available, instead of trueness, the recovery can be determined as described under 4.1.2.1 below.

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Source: https://www.legislation.gov.uk/eudn/2002/657/annex/chapter/3.1/division/3.1.1.2 (the official version)
Page: https://openlegislation.uk/eu-decision-2002-657/annex/chapter-3.1/division-3.1.1.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.