# Commission Decision of 4 August 2006 approving a Diagnostic Manual for avian influenza as provided for in Council Directive 2005/94/EC (notified under document number C(2006) 3477) (Text with EEA relevance) (2006/437/EC), Division 3: Post-mortem lesions in birds infected with HPAI virus

Extent: E+W+S+N.I.

Birds that die peracutely may show minimal gross lesions, consisting of dehydration and congestion of viscera and muscles.
In birds that die after a prolonged clinical course, petechial and ecchymotic haemorrhages occur throughout the body, particularly in the larynx, trachea, proventriculus and epicardial fat, and on serosal surfaces adjacent to the sternum. There is extensive subcutaneous oedema, particularly around the head and hocks. The carcase may be dehydrated. Yellow or grey necrotic foci may be present in the spleen, liver, kidneys and lungs. The air sac may contain an exudate. The spleen may be enlarged and haemorrhagic.
AI is characterised histologically by vascular disturbances leading to oedema, haemorrhages and perivascular cuffing, especially in the myocardium, spleen, lungs, brain, pancreas and wattles. Necrotic foci are present in the lungs, liver and kidneys. Gliosis, vascular proliferation and neuronal degeneration may be present in the brain.

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Source: https://www.legislation.gov.uk/eudn/2006/437/annex/chapter/II/division/3 (the official version)
Page: https://openlegislation.uk/eu-decision-2006-437/annex/chapter-II/division-3
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.