# Commission Decision of 4 August 2006 approving a Diagnostic Manual for avian influenza as provided for in Council Directive 2005/94/EC (notified under document number C(2006) 3477) (Text with EEA relevance) (2006/437/EC), Division 4: Requirements for Laboratories (containment levels 1 to 4)

Extent: E+W+S+N.I.

In accordance with Directive 2000/54/EC of the European Parliament and of the Council of 18 September 2000 on the protection of workers from risks related to exposure to biological agents at work (seventh individual Directive within the meaning of Article 16(1) of Directive 89/391/EEC) (OJ L 262, 17.10.2000, p. 21), Directive 90/219/EEC and European Norms: EN 12128; EN 12740; EN 12741.
Containment measures
Containment level
1
2
3
4
Laboratory suite: isolation
no
yes
yes
yes
Laboratories separated by doors
no
yes
yes
yes
An observation window or alternative must be present so that occupants can be seen
optional
optional
optional
yes
Hand washing facilities must be provided for personnel
yes
yes
yes
yes
Disinfecting facilities (hands) must be provided
optional
yes
yes
yes
Restricted access
no
yes
yes
yes
Specific measures to control aerosol
no
Yes
minimise
Yes
prevent
Yes
prevent
Biohazard sign on the door
no
yes
yes
yes
Shower
no
no
optional
yes
Eye irrigation
yes
yes
yes
yes
Laboratory: sealable for fumigation
no
no
yes
yes
Surfaces resistant to water, acids, alkalis, solvents, disinfectants, decontamination agents and easy to clean
Yes (bench)
Yes (bench)
Yes (bench, floor)
Yes (bench, floor)
Entry to lab via airlock
no
no
optional
yes
Negative pressure relative to the pressure of the immediate environment
no
no
optional
yes
Extract and input air from laboratory must be HEPA-filtered
no
no
yes (extract air)
yes
Autoclave
on site
in the building
en suite
in lab, double ended
Protective clothing
Suitable protective clothing
Suitable protective clothing
Suitable protective clothing (optional footwear)
Complete change of clothing
Gloves
no
optional
yes
yes
Efficient vector control (e.g. for rodents and insects)
optional
yes
yes
yes
Safe Storage of a biological agent
yes
yes
yes
yes
Laboratory to contain its own equipment
no
no
Recom-mended
yes
There are additional European Norms which deal with the management and organisation of laboratories.
There are other national and international regulations and recommendations which must be followed. The WHO has published its Laboratory Biosafety Manual 3rd Edition on its website:
http://www.who.int/csr/resources/publications/biosafety/WHO_CDS_CSR_LYO_2004_11/en/

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Source: https://www.legislation.gov.uk/eudn/2006/437/annex/chapter/XIV/division/4 (the official version)
Page: https://openlegislation.uk/eu-decision-2006-437/annex/chapter-XIV/division-4
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.