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Division Diagnostic criteria for a probable or a possible case:

United Kingdom

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  • EEG does not show the typical appearancef1 of sporadic CJDf2 in the early stages of the illness

  • Bilateral pulvinar high signal on MRI brain scan

  • A positive tonsil biopsyf3

Annotations

Footnotes

f1

The typical appearance of the EEG in sporadic CJD consists of generalised periodic complexes at approximately one per second. These may occasionally be seen in the late stages of VCJD.

f2

The typical appearance of the EEG in sporadic CJD consists of generalised periodic complexes at approximately one per second. These may occasionally be seen in the late stages of VCJD.

f3

Tonsil biopsy is not recommended routinely nor in cases with EEG appearances typical of sporadic CJD, but may be useful in suspect cases in which the clinical features are compatible with VCJD and MRI does not show pulvinar high signal.