Division Laboratory criteria
United Kingdom
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Laboratory criteria for case confirmation
At least one of the following three:
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Isolation of rubella virus from a clinical specimen
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Detection of rubella virus nucleic acid in a clinical specimen
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Rubella virus specific antibody response (IgG) in serum or saliva
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Laboratory criteria for probable case
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Rubella virus specific antibody response (IgM)f1
Laboratory results need to be interpreted according to the vaccination status
Annotations
Footnotes
- f1
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When rubella in pregnancy is suspected, further confirmation of a positive rubella IgM results is required (e.g. a rubella specific IgG avidity test showing a low avidity). In certain situations, such as confirmed rubella outbreaks detection of rubella virus IgM can be considered confirmatory in non-pregnant cases.