{
  "url": "https://openlegislation.uk/eu-decision-2008-426/annex/division-SEVERE/division-2",
  "json_url": "https://openlegislation.uk/eu-decision-2008-426/annex/division-SEVERE/division-2.json",
  "legislation": "eudn/2008/426",
  "legislation_title": "Commission Decision of 28 April 2008 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council (notified under document number C(2008) 1589) (Text with EEA relevance) (2008/426/EC)",
  "legislation_url": "https://openlegislation.uk/eu-decision-2008-426",
  "path": "annex/division/SEVERE/division/2",
  "kind": "division",
  "number": null,
  "heading": "Laboratory criteria",
  "text": "Laboratory criteria for case confirmation\nAt least one of the following three:\nIsolation of virus in cell culture from any clinical specimen and identification of SARS-CoV using method such as RT-PCR\nDetection SARS-CoV nucleic acid in at least one of the following three:\nAt least two different clinical specimens (e.g. nasopharyngeal swab and stool)\nThe same clinical specimen collected on two or more occasions during the course of the illness (e.g. sequential nasopharyngeal aspirates)\nTwo different assays or repeat RT-PCR using a new RNA extract from the original clinical sample on each occasion of testing\nSARS-CoV specific antibody response by one of the following two:\nSeroconversion by ELISA or IFA in acute and convalescent phase serum tested in parallel\nFourfold or greater rise in antibody titre between acute and convalescent phase sera tested in parallel\nLaboratory criteria for a probable case\nAt least one of the following two:\nA single positive antibody test for SARS-CoV\nA positive PCR result for SARS-CoV on a single clinical specimen and assay",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudn/2008/426/annex/division/SEVERE/division/2",
    "retrieved_at": "2026-11-01T15:16:48.847189+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}