# Commission Implementing Decision of 8 August 2012 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council (notified under document C(2012) 5538) (Text with EEA relevance) (2012/506/EU), Division: Laboratory Criteria

Extent: E+W+S+N.I.

Laboratory criteria for case confirmation
At least one of the following three:
Isolation of Legionella spp. from respiratory secretions or any normally sterile site
Detection of Legionella pneumophila antigen in urine
Significant rise in specific antibody level to Legionella pneumophila serogroup 1 in paired serum samples
Laboratory criteria for a probable case
At least one of the following four:
Detection of Legionella pneumophila antigen in respiratory secretions or lung tissue e.g. by DFA staining using monoclonal-antibody derived reagents
Detection of Legionella spp. nucleic acid in respiratory secretions, lung tissue or any normally sterile site
Significant rise in specific antibody level to Legionella pneumophila other than serogroup 1 or other Legionella spp. in paired serum samples
Single high level of specific antibody to Legionella pneumophila serogroup 1 in serum

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Source: https://www.legislation.gov.uk/eudn/2012/506/annex/division/2/division/2.21/division/2 (the official version)
Page: https://openlegislation.uk/eu-decision-2012-506/annex/division-2/division-2.21/division-2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.