{
  "url": "https://openlegislation.uk/eu-decision-2012-506/annex/division-3/division-3.1/division-3.1.9/division-1",
  "json_url": "https://openlegislation.uk/eu-decision-2012-506/annex/division-3/division-3.1/division-3.1.9/division-1.json",
  "legislation": "eudn/2012/506",
  "legislation_title": "Commission Implementing Decision of 8 August 2012 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council (notified under document C(2012) 5538) (Text with EEA relevance) (2012/506/EU)",
  "legislation_url": "https://openlegislation.uk/eu-decision-2012-506",
  "path": "annex/division/3/division/3.1/division/3.1.9/division/1",
  "kind": "division",
  "number": null,
  "heading": "NEO-CSEP: Clinical Sepsis",
  "text": "ALL of the 3 following criteria:\nSupervising physician started appropriate antimicrobial therapy for sepsis for at least five days.\nNo detection of pathogens in blood culture or not tested\nNo obvious infection at another site\nAND two of the following criteria (without other apparent cause):\nFever (> 38 °C) or temperature instability (frequent post-set of the incubator) or hypothermia (< 36,5 °C)\nTachycardia (> 200/min) or new/increased bradycardia (< 80/min)\nCapillary refilling time (CRT) > 2 s\nNew or increased apnoea (s) (> 20 s)\nUnexplained metabolic acidosis\nNew-onset hyperglycaemia (> 140 mg/dl)\nAnother sign of sepsis (skin colour (only if the CRT is not used), laboratory signs (CRP, interleukin), increased oxygen requirement (intubation), unstable general condition of the patient, apathy)",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudn/2012/506/annex/division/3/division/3.1/division/3.1.9/division/1",
    "retrieved_at": "2026-11-01T15:15:21.976168+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}