# Commission Implementing Decision of 8 August 2012 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council (notified under document C(2012) 5538) (Text with EEA relevance) (2012/506/EU), Division: NEO-CSEP: Clinical Sepsis

Extent: E+W+S+N.I.

ALL of the 3 following criteria:
Supervising physician started appropriate antimicrobial therapy for sepsis for at least five days.
No detection of pathogens in blood culture or not tested
No obvious infection at another site
AND two of the following criteria (without other apparent cause):
Fever (> 38 °C) or temperature instability (frequent post-set of the incubator) or hypothermia (< 36,5 °C)
Tachycardia (> 200/min) or new/increased bradycardia (< 80/min)
Capillary refilling time (CRT) > 2 s
New or increased apnoea (s) (> 20 s)
Unexplained metabolic acidosis
New-onset hyperglycaemia (> 140 mg/dl)
Another sign of sepsis (skin colour (only if the CRT is not used), laboratory signs (CRP, interleukin), increased oxygen requirement (intubation), unstable general condition of the patient, apathy)

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Source: https://www.legislation.gov.uk/eudn/2012/506/annex/division/3/division/3.1/division/3.1.9/division/1 (the official version)
Page: https://openlegislation.uk/eu-decision-2012-506/annex/division-3/division-3.1/division-3.1.9/division-1
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.