{
  "url": "https://openlegislation.uk/eu-decision-2013-674/annex/division-3/division-3.8/division-3.8.5/division-b",
  "json_url": "https://openlegislation.uk/eu-decision-2013-674/annex/division-3/division-3.8/division-3.8.5/division-b.json",
  "legislation": "eudn/2013/674",
  "legislation_title": "Commission Implementing Decision of 25 November 2013 on Guidelines on Annex I to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products (Text with EEA relevance) (2013/674/EU)",
  "legislation_url": "https://openlegislation.uk/eu-decision-2013-674",
  "path": "annex/division/3/division/3.8/division/3.8.5/division/b",
  "kind": "division",
  "number": "(b)",
  "heading": "Impurities in the substances and raw materials",
  "text": "Impurities can have a major impact on the overall toxicity of any substance. It is important to check the impurities profile of a substance to avoid, or at least assess, any additional risk from the impurities. In the absence of safety data from toxicological studies, the threshold of toxicological concern (TTC) might be a useful tool for assessing the safety of certain impurities.\nWhen toxicological studies are used to characterise the toxicological profile of a substance, the purity and impurities profile of the substance used in the toxicological studies should be described. If the batches actually used in the formulation of the cosmetic product do not have a comparable impurity profile, the differences need to be assessed.",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "footnote",
      "label": "f1",
      "text": "R. Kroes, A. G. Renwick, V. Feron, C. L. Galli, M. Gibney, H. Greim, R. H. Guy, J. C. Lhuguenot, J. J. M. van de Sandt, Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients, Food and Chemical Toxicology 45 (2007), pp. 2533–2562."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudn/2013/674/annex/division/3/division/3.8/division/3.8.5/division/b",
    "retrieved_at": "2026-11-01T15:14:57.936012+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}