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Division Laboratory Criteria

United Kingdom

Original text. Later amendments are not shown.

At least one of the following four:

  • Isolation of rubella virus from a clinical specimen

  • Detection of rubella virus nucleic acid in a clinical specimen

  • Rubella IgM antibody detectionf1

  • Rubella IgG seroconversion or significant rise in rubella IgG antibody titre in paired specimens tested in parallel.

Laboratory results need to be interpreted according to the vaccination status (possible persistence of IgM antibodies upon vaccination).

Annotations

Footnotes

f1

In elimination settings, additional testing may be considered in certain situations to exclude false-positive IgM results (WHO Manual for the Laboratory Surveillance of Measles and Rubella Viruses, 2017).