# Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions (Text with EEA relevance), Division: Laboratory criteria for case confirmation:

Extent: E+W+S+N.I.

At least one of the following five:
TBE specific IgM AND IgG antibodies in blood
TBE specific IgM antibodies in CSF
Seroconversion or four-fold increase of TBE-specific antibodies in paired serum samples
Detection of TBE viral nucleic acid in a clinical specimen,
Isolation of TBE virus from clinical specimen

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Source: https://www.legislation.gov.uk/eudn/2018/945/annex/II/division/3/division/3.46/division/2/division/1 (the official version)
Page: https://openlegislation.uk/eu-decision-2018-945/annex-II/division-3/division-3.46/division-2/division-1
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.