# Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions (Text with EEA relevance), Division: CNS-IC: Intracranial infection (brain abscess, subdural or epidural infection, encephalitis)

Extent: E+W+S+N.I.

Intracranial infection must meet at least one of the following criteria:
Patient has organisms cultured from brain tissue or dura
Patient has an abscess or evidence of intracranial infection seen during a surgical operation or histopathologic examination
Patient has at least 2 of the following signs or symptoms with no other recognized cause: headache, dizziness, fever (> 38 °C), localizing neurologic signs, changing level of consciousness, or confusion
AND at least 1 of the following:
organisms seen on microscopic examination of brain or abscess tissue obtained by needle aspiration or by biopsy during a surgical operation or autopsy
positive antigen test on blood or urine
radiographic evidence of infection (for example, abnormal findings on ultrasound, CT scan, MRI, radionuclide brain scan, or arteriogram)
diagnostic single antibody titre (IgM) or 4-fold increase in paired sera (IgG) for pathogen
AND if diagnosis is made antemortem, physician institutes appropriate antimicrobial therapy.

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Source: https://www.legislation.gov.uk/eudn/2018/945/annex/II/division/4/division/4.1/division/4.1.3/division/1 (the official version)
Page: https://openlegislation.uk/eu-decision-2018-945/annex-II/division-4/division-4.1/division-4.1.3/division-1
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.