{
  "url": "https://openlegislation.uk/eu-decision-2018-945/annex-II/division-4/division-4.1/division-4.1.9/division-1",
  "json_url": "https://openlegislation.uk/eu-decision-2018-945/annex-II/division-4/division-4.1/division-4.1.9/division-1.json",
  "legislation": "eudn/2018/945",
  "legislation_title": "Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions (Text with EEA relevance)",
  "legislation_url": "https://openlegislation.uk/eu-decision-2018-945",
  "path": "annex/II/division/4/division/4.1/division/4.1.9/division/1",
  "kind": "division",
  "number": null,
  "heading": "NEO-CSEP: Clinical Sepsis",
  "text": "ALL of the three following criteria:\nSupervising physician started appropriate antimicrobial therapy for sepsis for at least 5 days\nNo detection of pathogens in blood culture or not tested\nNo obvious infection at another site\nAND 2 of the following criteria (without other apparent cause):\nFever (> 38 °C) or temperature instability (frequent post-set of the incubator) or hypothermia (< 36,5 °C)\nTachycardia (> 200/min) or new/increased bradycardia (< 80/min)\nCapillary refilling time (CRT) > 2s\nNew or increased apnoea (s) (> 20s)\nUnexplained metabolic acidosis\nNew-onset hyperglycemia (> 140 mg/dl)\nAnother sign of sepsis (skin colour (only if the CRT is not used), laboratory signs (CRP, interleukin), increased oxygen requirement (intubation), unstable general condition of the patient, apathy)",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudn/2018/945/annex/II/division/4/division/4.1/division/4.1.9/division/1",
    "retrieved_at": "2026-11-01T15:13:03.598650+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}