# Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions (Text with EEA relevance), Division: NEO-CSEP: Clinical Sepsis

Extent: E+W+S+N.I.

ALL of the three following criteria:
Supervising physician started appropriate antimicrobial therapy for sepsis for at least 5 days
No detection of pathogens in blood culture or not tested
No obvious infection at another site
AND 2 of the following criteria (without other apparent cause):
Fever (> 38 °C) or temperature instability (frequent post-set of the incubator) or hypothermia (< 36,5 °C)
Tachycardia (> 200/min) or new/increased bradycardia (< 80/min)
Capillary refilling time (CRT) > 2s
New or increased apnoea (s) (> 20s)
Unexplained metabolic acidosis
New-onset hyperglycemia (> 140 mg/dl)
Another sign of sepsis (skin colour (only if the CRT is not used), laboratory signs (CRP, interleukin), increased oxygen requirement (intubation), unstable general condition of the patient, apathy)

---
Source: https://www.legislation.gov.uk/eudn/2018/945/annex/II/division/4/division/4.1/division/4.1.9/division/1 (the official version)
Page: https://openlegislation.uk/eu-decision-2018-945/annex-II/division-4/division-4.1/division-4.1.9/division-1
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.