{
  "url": "https://openlegislation.uk/eu-decision-2018-945/annex-II/division-4/division-4.3/division-1/division-2/division-3",
  "json_url": "https://openlegislation.uk/eu-decision-2018-945/annex-II/division-4/division-4.3/division-1/division-2/division-3.json",
  "legislation": "eudn/2018/945",
  "legislation_title": "Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions (Text with EEA relevance)",
  "legislation_url": "https://openlegislation.uk/eu-decision-2018-945",
  "path": "annex/II/division/4/division/4.3/division/1/division/2/division/3",
  "kind": "division",
  "number": null,
  "heading": "Clinically Resistant (R)",
  "text": "a micro-organism is defined as resistant (R) by a level of antimicrobial exposure associated with a high likelihood of therapeutic failure.\nClinical breakpoints are presented as:\nS: MIC ≤ x mg/L; disk diffusion zone diameter ≥ σ mm\nI: MIC > x, ≤ y mg/L; disk diffusion zone diameter ≥ ρ mm, < σ mm\nR: MIC > y mg/L; disk diffusion zone diameter < ρ mm",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "footnote",
      "label": "f1",
      "text": "http://www.eucast.org/clinical_breakpoints/. Equivalent quantitative antimicrobial susceptibility testing (AST) methods may be used instead of MIC or disk diffusion if endorsed by EUCAST."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudn/2018/945/annex/II/division/4/division/4.3/division/1/division/2/division/3",
    "retrieved_at": "2026-11-01T15:13:03.598650+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}