Part A Template for the submission of non-technical project summaries referred to in article 43(1) of directive 2010/63/EU

United Kingdom

Including scientific terms which may consist of more than 5 individual words and excluding species and purposes entered elsewhere in the document
To be provided via a dropdown menu
List of purposes in accordance with statistical reporting categories and sub-categories in Annex III to this Decision
Species in accordance with statistical reporting categories in Annex III to this Decision, with an additional option of ‘non-specified mammal’ to safeguard anonymity in exceptional cases
Species to be populated from the previous response to select from under the relevant category (proportions)
Multiple choices per species possible
Multiple choices possible; applicable to those MS where this information is required by the legislation
Title of the project
Duration of project (in months)
Key Words (maximum of 5)^f1
Purpose of project ^f2 (multiple choices possible)	Basic research^f3 Translational and applied research Regulatory use and routine production: Quality control (including batch safety and potency testing) Other efficacy and tolerance testing Toxicity and other safety testing including pharmacology Routine production Protection of the natural environment in the interests of the health or welfare of human beings or animals Preservation of species Higher education Training Forensic enquiries Maintenance of colonies of genetically altered animals, not used in other procedures
Objectives and predicted benefits of the project
Describe the objectives of the project (for example, addressing certain scientific unknowns, or scientific or clinical needs).
What are the potential benefits likely to derive from this project? Explain how science could be advanced, or humans, animals or environment may ultimately benefit from the project. Where applicable, differentiate between short-term benefits (within the duration of the project) and long-term benefits (which may accrue after the project is finished).
Predicted harms
In what procedures will the animals typically be used (for example, injections, surgical procedures)? Indicate the number and duration of these procedures.
What are the expected impacts/adverse effects on the animals, for example pain, weight loss, inactivity/reduced mobility, stress, abnormal behaviour, and the duration of those effects?
What species and numbers of animals are expected to be used? What are the expected severities and the numbers of animals in each severity category (per species)?	Species ^f4	Estimated total numbers	Estimated numbers per severity
			Non-recovery	Mild	Moderate	Severe





What will happen to the animals kept alive at the end of the procedure?^f5 ^, ^f6	Estimated number to be reused		Estimated number to be returned to habitat/husbandry system		Estimated number to be rehomed
Please provide reasons for the planned fate of the animals after the procedure.
Application of the Three Rs
1. Replacement State which non-animal alternatives are available in this field and why they cannot be used for the purposes of the project.
2. Reduction Explain how the numbers of animals for this project were determined. Describe steps that have been taken to reduce the number of animals to be used, and principles used to design studies. Where applicable, describe practices that will be used throughout the project to minimise the number of animals used consistent with scientific objectives. Those practices may include e.g. pilot studies, computer modelling, sharing of tissue and reuse.
3. Refinement Give examples of the specific measures (e.g., increased monitoring, post-operative care, pain management, training of animals) to be taken, in relation to the procedures, to minimise welfare costs (harms) to the animals. Describe the mechanisms to take up emerging refinement techniques during the lifetime of the project.
Explain the choice of species and the related life stages.
Project selected for Retrospective Assessment ^f7	Deadline		Contains severe procedures		Uses non-human primates		Other reason

Annotations

Footnotes

f1: Including scientific terms which may consist of more than 5 individual words and excluding species and purposes entered elsewhere in the document
f2: To be provided via a dropdown menu
f3: List of purposes in accordance with statistical reporting categories and sub-categories in Annex III to this Decision
f4: Species in accordance with statistical reporting categories in Annex III to this Decision, with an additional option of ‘non-specified mammal’ to safeguard anonymity in exceptional cases
f5: Species to be populated from the previous response to select from under the relevant category (proportions)
f6: Multiple choices per species possible
f7: Multiple choices possible; applicable to those MS where this information is required by the legislation