Part B Template for the submission of an update to the non-technical project summary referred to in article 43(2) of directive 2010/63/EU

United Kingdom

Multiple choices possible
Species in accordance with statistical reporting categories in Annex III to this Decision, with an additional option of ‘non-specified mammal’ to safeguard anonymity in exceptional cases
Title (as per Non-technical Project Summary)
Reason for Retrospective Assessment ^f1			Using non-human primates	Contains ‘severe’procedures	Other reason
Explain ‘Other reason’
Achievement of objectives
Explain briefly whether, and to what extent, the objectives set out in the authorised project have been achieved. Provide reasons if objectives have not been attained. Have there been any other significant findings? What benefits have resulted from the work to date, and are further benefits expected? Have the results of this project been disseminated, including where hypotheses are not proven? If so, describe how. If not, indicate how and when results are expected to be publicised.
Harms
Species ^f2	Total numbers of animals used	Numbers of animals per actual severity
		Non-recovery	Mild	Moderate	Severe





How do numbers of animals used and actual severities compare with those estimated? Where the actual numbers are higher than the estimated numbers, please provide an explanation. Where the actual numbers are lower, please provide an explanation unless that difference is a result of Reduction or Refinement?
How does the fate of animals kept alive at the end of the study compare with the estimated fate? Please provide an explanation.
Any elements that may contribute to further implementation of the Three Rs:
1. Replacement
With the knowledge obtained from this project, have any new approaches that could replace some or all of the use of animals in similar projects been identified/developed (including the development/validation of new in vitro or in silico techniques)?
2. Reduction
With the knowledge obtained from this project, could the experimental design be improved to enable any further reduction of the use of animals, and if so, how? Provide an explanation where numbers of animals used were lower than those originally estimated.
3. Refinement
Provide an explanation where the actual severities were lower than those originally estimated. With the new knowledge obtained from this project, are the animal models used still the most appropriate? Please specify per species/model, where appropriate. List any novel refinements introduced during the project to reduce harm to the animals or to improve their welfare. What are the potential opportunities for further refinement in the future, for example, emerging technologies, techniques, improved welfare assessment methods, earlier endpoints, housing/husbandry measures?
4. Other
How are the findings for further implementation of the Three Rs disseminated?
Additional comments

Annotations

Footnotes

f1: Multiple choices possible
f2: Species in accordance with statistical reporting categories in Annex III to this Decision, with an additional option of ‘non-specified mammal’ to safeguard anonymity in exceptional cases