{
  "url": "https://openlegislation.uk/eu-directive-2000-54/annex-III/division-BACTERIA/division-2",
  "json_url": "https://openlegislation.uk/eu-directive-2000-54/annex-III/division-BACTERIA/division-2.json",
  "legislation": "eudr/2000/54",
  "legislation_title": "Directive 2000/54/EC of the European Parliament and of the Council of 18 September 2000 on the protection of workers from risks related to exposure to biological agents at work (seventh individual directive within the meaning of Article 16(1) of Directive 89/391/EEC)",
  "legislation_url": "https://openlegislation.uk/eu-directive-2000-54",
  "path": "annex/III/division/BACTERIA/division/2",
  "kind": "division",
  "number": null,
  "heading": "VIRUSES (*)",
  "text": "(*) See paragraph 7 of the introductory notes.\nSee paragraph 7 of the introductory notes.\nClassification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use.\nSee paragraph 8 of the introductory notes.\nTick-borne encephalitis.\nHepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus.\nOnly for types A and B.\nRecommended for work involving direct contact with these agents.\nTwo viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus.\nVariant of cowpox virus.\nVariant of Vaccinia.\nAt present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them.\nIn line with Article 16(1)(c), non-propagative diagnostic laboratory work involving SARS-CoV-2 should be conducted at a facility using procedures equivalent to at least containment level 2. Propagative work involving SARS-CoV-2 should be conducted at a containment level 3 laboratory with air pressure negative to atmosphere.\nBiological agent (virus species or indicated taxonomy order)\nClassification\nNotes\nBunyavirales (O)\nHantaviridae (F)\nOrthohantavirus (G)\nAndes orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])\n3\nBayou orthohantavirus\n3\nBlack Creek Canal orthohantavirus\n3\nCano Delgadito orthohantavirus\n3\nChoclo orthohantavirus\n3\nDobrava-Belgrade orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])\n3\nEl Moro Canyon orthohantavirus\n3\nHantaan orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])\n3\nLaguna Negra orthohantavirus\n3\nProspect Hill orthohantavirus\n2\nPuumala orthohantavirus (Hantavirus species causing Nephropathia Epidemica [NE])\n2\nSeoul orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])\n3\nSin Nombre orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])\n3\nOther hantaviruses known to be pathogenic\n2\nNairoviridae (F)\nOrthonairovirus (G)\nCrimean-Congo haemorrhagic fever orthonairovirus\n4\nDugbe orthonairovirus\n2\nHazara orthonairovirus\n2\nNairobi sheep disease orthonairovirus\n2\nOther nairoviruses known to be pathogenic\n2\nPeribunyaviridae (F)\nOrthobunyavirus (G)\nBunyamwera orthobunyavirus (Germiston virus)\n2\nCalifornia encephalitis orthobunyavirus\n2\nOropouche orthobunyavirus\n3\nOther orthobunyaviruses known to be pathogenic\n2\nPhenuiviridae (F)\nPhlebovirus (G)\nBhanja phlebovirus\n2\nPunta Toro phlebovirus\n2\nRift Valley fever phlebovirus\n3\nSandfly fever Naples phlebovirus (Toscana Virus)\n2\nSFTS phlebovirus (Severe Fever with Thrombocytopenia Syndrome-Virus)\n3\nOther phleboviruses known to be pathogenic\n2\nHerpesvirales (O)\nHerpesviridae (F)\nCytomegalovirus (G)\nHuman betaherpesvirus 5 (Cytomegalovirus)\n2\nLymphocryptovirus (G)\nHuman gammaherpesvirus 4 (Epstein-Barr virus)\n2\nRhadinoovirus (G)\nHuman gammaherpesvirus 8\n2\nD\nRoseolovirus (G)\nHuman betaherpesvirus 6A (Human B-lymphotropic virus)\n2\nHuman betaherpesvirus 6B\n2\nHuman betaherpesvirus 7\n2\nSimplexvirus (G)\nMacacine alphaherpesvirus 1 (Herpesvirus simiae, Herpes B virus)\n3\nHuman alphaherpesvirus 1 (Human herpesvirus 1, Herpes simplex virus type 1)\n2\nHuman alphaherpesvirus 2 (Human herpesvirus 2, Herpes simplex virus type 2)\n2\nVaricellovirus (G)\nHuman alphaherpesvirus 3 (Herpesvirus varicella-zoster)\n2\nV\nMononegavirales (O)\nFiloviridae (F)\nEbolavirus (G)\n4\nMarburgvirus (G)\nMarburg marburgvirus\n4\nParamyxoviridae (F)\nAvulavirus (G)\nNewcastle disease virus\n2\nHenipavirus (G)\nHendra henipavirus\n4\nNipah henipavirus\n4\nMorbillivirus (G)\nMeasles morbillivirus\n2\nV\nRespirovirus (G)\nHuman respirovirus 1 (Parainfluenza virus 1)\n2\nHuman respirovirus 3 (Parainfluenza virus 3)\n2\nRubulavirus (G)\nMumps rubulavirus\n2\nV\nHuman rubulavirus 2 (Parainfluenza virus 2)\n2\nHuman rubulavirus 4 (Parainfluenza virus 4)\n2\nPneumoviridae (F)\nMetapneumovirus (G)\nOrthopneumovirus (G)\nHuman orthopneumovirus (Respiratory syncytial virus)\n2\nRhabdoviridae (F)\nLyssavirus (G)\nAustralian bat lyssavirus\n3\nV\nDuvenhage lyssavirus\n3\nV\nEuropean bat lyssavirus 1\n3\nV\nEuropean bat lyssavirus 2\n3\nV\nLagos bat lyssavirus\n3\nMokola lyssavirus\n3\nRabies lyssavirus\n3\nV\nVesiculovirus (G)\nVesicular stomatitis virus, Alagoas vesiculovirus\n2\nVesicular stomatitis virus, Indiana vesiculovirus\n2\nVesicular stomatitis virus, New Jersey vesiculovirus\n2\nPiry vesiculovirus (Piry virus)\n2\nNidovirales (O)\nCoronaviridae (F)\nBetacoronavirus (G)\nSevere acute respiratory syndrome-related coronavirus (SARS-virus)\n3\nSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)\n3\nMiddle East respiratory syndrome coronavirus (MERS-virus)\n3\nOther Coronaviridae known to be pathogenic\n2\nPicornavirales (O)\nPicornaviridae (F)\nCardiovirus (G)\nSaffold virus\n2\nCosavirus (G)\nCosavirus A\n2\nEnterovirus (G)\nEnterovirus A\n2\nEnterovirus B\n2\nEnterovirus C\n2\nEnterovirus D, Human Enterovirus type 70 (Acute haemorrhagic conjunctivitis virus)\n2\nRhinoviruses\n2\nPoliovirus, type 1 and 3\n2\nV\nPoliovirus, type 2\n3\nV\nHepatovirus (G)\nHepatovirus A (Hepatitis A virus, Human Enterovirus type 72)\n2\nV\nKobuvirus (G)\nAichivirus A (Aichi virus 1)\n2\nParechovirus (G)\nParechoviruses A\n2\nParechoviruses B (Ljungan virus)\n2\nOther Picornaviridae known to be pathogenic\n2\nUnassigned (O)\nAdenoviridae (F)\n2\nAstroviridae (F)\n2\nArenaviridae (F)\nMammarenavirus (G)\nBrazilian mammarenavirus\n4\nChapare mammarenavirus\n4\nFlexal mammarenavirus\n3\nGuanarito mammarenavirus\n4\nJunín mammarenavirus\n4\nLassa mammarenavirus\n4\nLujo mammarenavirus\n4\nLymphocytic choriomeningitis mammarenavirus, neurotropic strains\n2\nLymphocytic choriomeningitis mammarenavirus (other strains)\n2\nMachupo mammarenavirus\n4\nMobala mammarenavirus\n2\nMopeia mammarenavirus\n2\nTacaribe mammarenavirus\n2\nWhitewater Arroyo mammarenavirus\n3\nCaliciviridae (F)\nNorovirus (G)\nNorovirus (Norwalk virus)\n2\nOther Caliciviridae known to be pathogenic\n2\nHepadnaviridae (F)\nOrthohepadnavirus (G)\nHepatitis B virus\n3\nV, D\nHepeviridae (F)\nOrthohepevirus (G)\nOrthohepevirus A (Hepatitis E virus)\n2\nFlaviviridae (F)\nFlavivirus (G)\nDengue virus\n3\nJapanese encephalitis virus\n3\nV\nKyasanur Forest disease virus\n3\nV\nLouping ill virus\n3\nMurray Valley encephalitis virus (Australia encephalitis virus)\n3\nOmsk haemorrhagic fever virus\n3\nPowassan virus\n3\nRocio virus\n3\nSt. Louis encephalitis virus\n3\nTick-borne encephalitis virus\nAbsettarov virus\n3\nHanzalova virus\n3\nHypr virus\n3\nKumlinge virus\n3\nNegishi virus\n3\nRussian spring-summer encephalitis\n3\nV\nTick-borne encephalitis virus Central European subtype\n3\nV\nTick-borne encephalitis virus Far Eastern Subtype\n3\nTick-borne encephalitis virus Siberian subtype\n3\nV\nWesselsbron virus\n3\nWest Nile fever virus\n3\nYellow fever virus\n3\nV\nZika virus\n2\nOther flaviviruses known to be pathogenic\n2\nHepacivirus (G)\nHepacivirus C (Hepatitis C virus)\n3\nD\nOrthomyxoviridae (F)\nGammainfluenzavirus (G)\nInfluenza C virus\n2\nV\nInfluenzavirus A (G)\nHighly Pathogenic Avian Influenza Viruses HPAIV (H5), e.g. H5N1\n3\nHighly Pathogenic Avian Influenza Viruses HPAIV (H7), e.g. H7N7, H7N9\n3\nInfluenza A virus\n2\nV\nInfluenza A virus A/New York/1/18 (H1N1) (Spanish flu 1918)\n3\nInfluenza A virus A/Singapore/1/57 (H2N2)\n3\nLow Pathogenic Avian Influenza Virus (LPAI) H7N9\n3\nInfluenzavirus B (G)\nInfluenza B virus\n2\nV\nThogoto virus (G)\nDhori virus (Tick-borne orthomyxoviridae : Dhori)\n2\nThogoto virus (Tick-borne orthomyxoviridae : Thogoto)\n2\nPapillomaviridae (F)\n2\nD\nParvoviridae (F)\nErythroparvovirus (G)\nPrimate erythroparvovirus 1 (Human parvovirus, B 19 virus)\n2\nPolyomaviridae (F)\nBetapolyomavirus (G)\nHuman polyomavirus 1 (BK virus)\n2\nD\nHuman polyomavirus 2 (JC virus)\n2\nD\nPoxviridae (F)\nMolluscipoxvirus (G)\nMolluscum contagiosum virus\n2\nOrthopoxvirus (G)\nCowpox virus\n2\nMonkeypox virus\n3\nV\nVaccinia virus (incl. Buffalopox virus , Elephantpox virus , Rabbitpox virus )\n2\nVariola (major and minor) virus\n4\nV\nParapoxvirus (G)\nOrf virus\n2\nPseudocowpox virus (Milkers’ node virus, parapoxvirus bovis)\n2\nYatapoxvirus (G)\nTanapox virus\n2\nYaba monkey tumor virus\n2\nReoviridae (F)\nSeadornavirus (G)\nBanna virus\n2\nColtivirus (G)\n2\nRotavirus es (G)\n2\nOrbivirus (G)\n2\nRetroviridae (F)\nDeltaretrovirus (G)\nPrimate T-lymphotropic virus 1 (Human T-cell lymphotropic virus, type 1)\n3\nD\nPrimate T-lymphotropic virus 2 (Human T-cell lymphotropic virus, type 2)\n3\nD\nLentivirus (G)\nHuman immunodeficiency virus 1\n3\nD\nHuman immunodeficiency virus 2\n3\nD\nSimian Immunodeficiency Virus (SIV)\n2\nTogaviridae (F)\nAlphavirus (G)\nCabassouvirus\n3\nEastern equine encephalomyelitis virus\n3\nV\nBebaru virus\n2\nChikungunya virus\n3\nEverglades virus\n3\nMayaro virus\n3\nMucambo virus\n3\nNdumu virus\n3\nO’nyong-nyong virus\n2\nRoss River virus\n2\nSemliki Forest virus\n2\nSindbis virus\n2\nTonate virus\n3\nVenezuelan equine encephalomyelitis virus\n3\nV\nWestern equine encephalomyelitis virus\n3\nV\nOther alphaviruses known to be pathogenic\n2\nRubivirus (G)\nRubella virus\n2\nV\nUnassigned (F)\nDeltavirus (G)\nHepatitis delta virus\n2\nV, D",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "F",
      "label": "F1",
      "text": "Substituted by Commission Directive (EU) 2019/1833 of 24 October 2019 amending Annexes I, III, V and VI to Directive 2000/54/EC of the European Parliament and of the Council as regards purely technical adjustments."
    },
    {
      "type": "F",
      "label": "F2",
      "text": "Inserted by Commission Directive (EU) 2020/739 of 3 June 2020 amending Annex III to Directive 2000/54/EC of the European Parliament and of the Council as regards the inclusion of SARS-CoV-2 in the list of biological agents known to infect humans and amending Commission Directive (EU) 2019/1833."
    },
    {
      "type": "footnote",
      "label": "f1",
      "text": "See paragraph 8 of the introductory notes."
    },
    {
      "type": "footnote",
      "label": "f2",
      "text": "In line with Article 16(1)(c), non-propagative diagnostic laboratory work involving SARS-CoV-2 should be conducted at a facility using procedures equivalent to at least containment level 2. Propagative work involving SARS-CoV-2 should be conducted at a containment level 3 laboratory with air pressure negative to atmosphere."
    },
    {
      "type": "footnote",
      "label": "f3",
      "text": "Classification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use."
    },
    {
      "type": "footnote",
      "label": "f4",
      "text": "Tick-borne encephalitis."
    },
    {
      "type": "footnote",
      "label": "f5",
      "text": "Only for types A and B."
    },
    {
      "type": "footnote",
      "label": "f6",
      "text": "Recommended for work involving direct contact with these agents."
    },
    {
      "type": "footnote",
      "label": "f7",
      "text": "Two viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus."
    },
    {
      "type": "footnote",
      "label": "f8",
      "text": "Variant of cowpox virus."
    },
    {
      "type": "footnote",
      "label": "f9",
      "text": "Variant of Vaccinia."
    },
    {
      "type": "footnote",
      "label": "f10",
      "text": "At present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them."
    },
    {
      "type": "footnote",
      "label": "f11",
      "text": "Hepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudr/2000/54/annex/III/division/BACTERIA/division/2",
    "retrieved_at": "2026-11-01T15:23:02.086169+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}