# Directive 2000/54/EC of the European Parliament and of the Council of 18 September 2000 on the protection of workers from risks related to exposure to biological agents at work (seventh individual directive within the meaning of Article 16(1) of Directive 89/391/EEC), Division: VIRUSES (*)

Extent: E+W+S+N.I.

(*) See paragraph 7 of the introductory notes.
See paragraph 7 of the introductory notes.
Classification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use.
See paragraph 8 of the introductory notes.
Tick-borne encephalitis.
Hepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus.
Only for types A and B.
Recommended for work involving direct contact with these agents.
Two viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus.
Variant of cowpox virus.
Variant of Vaccinia.
At present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them.
In line with Article 16(1)(c), non-propagative diagnostic laboratory work involving SARS-CoV-2 should be conducted at a facility using procedures equivalent to at least containment level 2. Propagative work involving SARS-CoV-2 should be conducted at a containment level 3 laboratory with air pressure negative to atmosphere.
Biological agent (virus species or indicated taxonomy order)
Classification
Notes
Bunyavirales (O)
Hantaviridae (F)
Orthohantavirus (G)
Andes orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])
3
Bayou orthohantavirus
3
Black Creek Canal orthohantavirus
3
Cano Delgadito orthohantavirus
3
Choclo orthohantavirus
3
Dobrava-Belgrade orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])
3
El Moro Canyon orthohantavirus
3
Hantaan orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])
3
Laguna Negra orthohantavirus
3
Prospect Hill orthohantavirus
2
Puumala orthohantavirus (Hantavirus species causing Nephropathia Epidemica [NE])
2
Seoul orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])
3
Sin Nombre orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])
3
Other hantaviruses known to be pathogenic
2
Nairoviridae (F)
Orthonairovirus (G)
Crimean-Congo haemorrhagic fever orthonairovirus
4
Dugbe orthonairovirus
2
Hazara orthonairovirus
2
Nairobi sheep disease orthonairovirus
2
Other nairoviruses known to be pathogenic
2
Peribunyaviridae (F)
Orthobunyavirus (G)
Bunyamwera orthobunyavirus (Germiston virus)
2
California encephalitis orthobunyavirus
2
Oropouche orthobunyavirus
3
Other orthobunyaviruses known to be pathogenic
2
Phenuiviridae (F)
Phlebovirus (G)
Bhanja phlebovirus
2
Punta Toro phlebovirus
2
Rift Valley fever phlebovirus
3
Sandfly fever Naples phlebovirus (Toscana Virus)
2
SFTS phlebovirus (Severe Fever with Thrombocytopenia Syndrome-Virus)
3
Other phleboviruses known to be pathogenic
2
Herpesvirales (O)
Herpesviridae (F)
Cytomegalovirus (G)
Human betaherpesvirus 5 (Cytomegalovirus)
2
Lymphocryptovirus (G)
Human gammaherpesvirus 4 (Epstein-Barr virus)
2
Rhadinoovirus (G)
Human gammaherpesvirus 8
2
D
Roseolovirus (G)
Human betaherpesvirus 6A (Human B-lymphotropic virus)
2
Human betaherpesvirus 6B
2
Human betaherpesvirus 7
2
Simplexvirus (G)
Macacine alphaherpesvirus 1 (Herpesvirus simiae, Herpes B virus)
3
Human alphaherpesvirus 1 (Human herpesvirus 1, Herpes simplex virus type 1)
2
Human alphaherpesvirus 2 (Human herpesvirus 2, Herpes simplex virus type 2)
2
Varicellovirus (G)
Human alphaherpesvirus 3 (Herpesvirus varicella-zoster)
2
V
Mononegavirales (O)
Filoviridae (F)
Ebolavirus (G)
4
Marburgvirus (G)
Marburg marburgvirus
4
Paramyxoviridae (F)
Avulavirus (G)
Newcastle disease virus
2
Henipavirus (G)
Hendra henipavirus
4
Nipah henipavirus
4
Morbillivirus (G)
Measles morbillivirus
2
V
Respirovirus (G)
Human respirovirus 1 (Parainfluenza virus 1)
2
Human respirovirus 3 (Parainfluenza virus 3)
2
Rubulavirus (G)
Mumps rubulavirus
2
V
Human rubulavirus 2 (Parainfluenza virus 2)
2
Human rubulavirus 4 (Parainfluenza virus 4)
2
Pneumoviridae (F)
Metapneumovirus (G)
Orthopneumovirus (G)
Human orthopneumovirus (Respiratory syncytial virus)
2
Rhabdoviridae (F)
Lyssavirus (G)
Australian bat lyssavirus
3
V
Duvenhage lyssavirus
3
V
European bat lyssavirus 1
3
V
European bat lyssavirus 2
3
V
Lagos bat lyssavirus
3
Mokola lyssavirus
3
Rabies lyssavirus
3
V
Vesiculovirus (G)
Vesicular stomatitis virus, Alagoas vesiculovirus
2
Vesicular stomatitis virus, Indiana vesiculovirus
2
Vesicular stomatitis virus, New Jersey vesiculovirus
2
Piry vesiculovirus (Piry virus)
2
Nidovirales (O)
Coronaviridae (F)
Betacoronavirus (G)
Severe acute respiratory syndrome-related coronavirus (SARS-virus)
3
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
3
Middle East respiratory syndrome coronavirus (MERS-virus)
3
Other Coronaviridae known to be pathogenic
2
Picornavirales (O)
Picornaviridae (F)
Cardiovirus (G)
Saffold virus
2
Cosavirus (G)
Cosavirus A
2
Enterovirus (G)
Enterovirus A
2
Enterovirus B
2
Enterovirus C
2
Enterovirus D, Human Enterovirus type 70 (Acute haemorrhagic conjunctivitis virus)
2
Rhinoviruses
2
Poliovirus, type 1 and 3
2
V
Poliovirus, type 2
3
V
Hepatovirus (G)
Hepatovirus A (Hepatitis A virus, Human Enterovirus type 72)
2
V
Kobuvirus (G)
Aichivirus A (Aichi virus 1)
2
Parechovirus (G)
Parechoviruses A
2
Parechoviruses B (Ljungan virus)
2
Other Picornaviridae known to be pathogenic
2
Unassigned (O)
Adenoviridae (F)
2
Astroviridae (F)
2
Arenaviridae (F)
Mammarenavirus (G)
Brazilian mammarenavirus
4
Chapare mammarenavirus
4
Flexal mammarenavirus
3
Guanarito mammarenavirus
4
Junín mammarenavirus
4
Lassa mammarenavirus
4
Lujo mammarenavirus
4
Lymphocytic choriomeningitis mammarenavirus, neurotropic strains
2
Lymphocytic choriomeningitis mammarenavirus (other strains)
2
Machupo mammarenavirus
4
Mobala mammarenavirus
2
Mopeia mammarenavirus
2
Tacaribe mammarenavirus
2
Whitewater Arroyo mammarenavirus
3
Caliciviridae (F)
Norovirus (G)
Norovirus (Norwalk virus)
2
Other Caliciviridae known to be pathogenic
2
Hepadnaviridae (F)
Orthohepadnavirus (G)
Hepatitis B virus
3
V, D
Hepeviridae (F)
Orthohepevirus (G)
Orthohepevirus A (Hepatitis E virus)
2
Flaviviridae (F)
Flavivirus (G)
Dengue virus
3
Japanese encephalitis virus
3
V
Kyasanur Forest disease virus
3
V
Louping ill virus
3
Murray Valley encephalitis virus (Australia encephalitis virus)
3
Omsk haemorrhagic fever virus
3
Powassan virus
3
Rocio virus
3
St. Louis encephalitis virus
3
Tick-borne encephalitis virus
Absettarov virus
3
Hanzalova virus
3
Hypr virus
3
Kumlinge virus
3
Negishi virus
3
Russian spring-summer encephalitis
3
V
Tick-borne encephalitis virus Central European subtype
3
V
Tick-borne encephalitis virus Far Eastern Subtype
3
Tick-borne encephalitis virus Siberian subtype
3
V
Wesselsbron virus
3
West Nile fever virus
3
Yellow fever virus
3
V
Zika virus
2
Other flaviviruses known to be pathogenic
2
Hepacivirus (G)
Hepacivirus C (Hepatitis C virus)
3
D
Orthomyxoviridae (F)
Gammainfluenzavirus (G)
Influenza C virus
2
V
Influenzavirus A (G)
Highly Pathogenic Avian Influenza Viruses HPAIV (H5), e.g. H5N1
3
Highly Pathogenic Avian Influenza Viruses HPAIV (H7), e.g. H7N7, H7N9
3
Influenza A virus
2
V
Influenza A virus A/New York/1/18 (H1N1) (Spanish flu 1918)
3
Influenza A virus A/Singapore/1/57 (H2N2)
3
Low Pathogenic Avian Influenza Virus (LPAI) H7N9
3
Influenzavirus B (G)
Influenza B virus
2
V
Thogoto virus (G)
Dhori virus (Tick-borne orthomyxoviridae : Dhori)
2
Thogoto virus (Tick-borne orthomyxoviridae : Thogoto)
2
Papillomaviridae (F)
2
D
Parvoviridae (F)
Erythroparvovirus (G)
Primate erythroparvovirus 1 (Human parvovirus, B 19 virus)
2
Polyomaviridae (F)
Betapolyomavirus (G)
Human polyomavirus 1 (BK virus)
2
D
Human polyomavirus 2 (JC virus)
2
D
Poxviridae (F)
Molluscipoxvirus (G)
Molluscum contagiosum virus
2
Orthopoxvirus (G)
Cowpox virus
2
Monkeypox virus
3
V
Vaccinia virus (incl. Buffalopox virus , Elephantpox virus , Rabbitpox virus )
2
Variola (major and minor) virus
4
V
Parapoxvirus (G)
Orf virus
2
Pseudocowpox virus (Milkers’ node virus, parapoxvirus bovis)
2
Yatapoxvirus (G)
Tanapox virus
2
Yaba monkey tumor virus
2
Reoviridae (F)
Seadornavirus (G)
Banna virus
2
Coltivirus (G)
2
Rotavirus es (G)
2
Orbivirus (G)
2
Retroviridae (F)
Deltaretrovirus (G)
Primate T-lymphotropic virus 1 (Human T-cell lymphotropic virus, type 1)
3
D
Primate T-lymphotropic virus 2 (Human T-cell lymphotropic virus, type 2)
3
D
Lentivirus (G)
Human immunodeficiency virus 1
3
D
Human immunodeficiency virus 2
3
D
Simian Immunodeficiency Virus (SIV)
2
Togaviridae (F)
Alphavirus (G)
Cabassouvirus
3
Eastern equine encephalomyelitis virus
3
V
Bebaru virus
2
Chikungunya virus
3
Everglades virus
3
Mayaro virus
3
Mucambo virus
3
Ndumu virus
3
O’nyong-nyong virus
2
Ross River virus
2
Semliki Forest virus
2
Sindbis virus
2
Tonate virus
3
Venezuelan equine encephalomyelitis virus
3
V
Western equine encephalomyelitis virus
3
V
Other alphaviruses known to be pathogenic
2
Rubivirus (G)
Rubella virus
2
V
Unassigned (F)
Deltavirus (G)
Hepatitis delta virus
2
V, D

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Source: https://www.legislation.gov.uk/eudr/2000/54/annex/III/division/BACTERIA/division/2 (the official version)
Page: https://openlegislation.uk/eu-directive-2000-54/annex-III/division-BACTERIA/division-2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.