# Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance), Division 1.4.2.2: Irrigation

Extent: E+W+S+N.I.

The eyes of the test animals should not be washed for at least 24 hours following instillation of the test substance, except for solids (see section 1.4.2.3.2), and in case of immediate corrosive or irritating effects. At 24 hours a washout may be used if considered appropriate.
Use of a satellite group of animals to investigate the influence of washing is not recommended unless it is scientifically justified. If a satellite group is needed, two rabbits should be used. Conditions of washing should be carefully documented, e.g., time of washing; composition and temperature of wash solution; duration, volume, and velocity of application.

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Source: https://www.legislation.gov.uk/eudr/2004/73/annex/2E/division/B/division/1/division/1.4/division/1.4.2/division/1.4.2.2 (the official version)
Page: https://openlegislation.uk/eu-directive-2004-73/annex-2E/division-B/division-1/division-1.4/division-1.4.2/division-1.4.2.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.