# Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance), Division 1.4.2.5: Local anaesthetics

Extent: E+W+S+N.I.

Local anaesthetics may be used on a case-by-case basis. If the weight-of-the-evidence analysis indicates that the substance has the potential to cause pain, or initial testing shows that a painful reaction will occur, a local anaesthetic may be used prior to instillation of the test substance. The type, concentration, and dose of the local anaesthetic should be carefully selected to ensure that differences in reaction to the test substance will not result from its use. The control eye should be similarly anaesthetised.

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Source: https://www.legislation.gov.uk/eudr/2004/73/annex/2E/division/B/division/1/division/1.4/division/1.4.2/division/1.4.2.5 (the official version)
Page: https://openlegislation.uk/eu-directive-2004-73/annex-2E/division-B/division-1/division-1.4/division-1.4.2/division-1.4.2.5
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.