{
  "url": "https://openlegislation.uk/eu-directive-2004-73/annex-2H/division-B.42/division-1/division-1.3/division-1.3.3/division-1.3.3.4",
  "json_url": "https://openlegislation.uk/eu-directive-2004-73/annex-2H/division-B.42/division-1/division-1.3/division-1.3.3/division-1.3.3.4.json",
  "legislation": "eudr/2004/73",
  "legislation_title": "Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance)",
  "legislation_url": "https://openlegislation.uk/eu-directive-2004-73",
  "path": "annex/2H/division/B.42/division/1/division/1.3/division/1.3.3/division/1.3.3.4",
  "kind": "division",
  "number": "1.3.3.4",
  "heading": "Observations",
  "text": "1.3.3.4.1 Clinical observations\nAnimals should be carefully observed once daily for any clinical signs, either of local irritation at the application site or of systemic toxicity. All observations are systematically recorded with individual records being maintained for each animal.\n1.3.3.4.2 Body Weights\nAs stated in section 1.3.3.1, individual animal body weights should be measured at the start of the test and at the scheduled kill of the animals.",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudr/2004/73/annex/2H/division/B.42/division/1/division/1.3/division/1.3.3/division/1.3.3.4",
    "retrieved_at": "2026-11-01T15:22:47.605967+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}