# Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance), Division 1.2: DEFINITIONS

Extent: E+W+S+N.I.

Adverse effect: is any treatment-related alteration from baseline that diminishes an organism's ability to survive, reproduce or adapt to the environment.
Dose: is the amount of test substance administered. Dose is expressed as weight (g, mg) or as weight of test substance per unit weight of the test animal (e.g. mg/Kg), or as constant dietary concentrations (ppm).
Dosage: is a general term comprising of dose, its frequency and the duration of dosing.
Neurotoxicity: is an adverse change in the structure or function of the nervous system that results from exposure to a chemical, biological or physical agent.
Neurotoxicant: is any chemical, biological or physical agent having the potential to cause neurotoxicity.
NOAEL: is the abbreviation for no-observed-adverse effect level and is the highest dose level where no adverse treatment-related findings are observed.

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Source: https://www.legislation.gov.uk/eudr/2004/73/annex/2H/division/B.43/division/1/division/1.2 (the official version)
Page: https://openlegislation.uk/eu-directive-2004-73/annex-2H/division-B.43/division-1/division-1.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.