# Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance), Division 1.2: DEFINITIONS

Extent: E+W+S+N.I.

Dermal irritation: is the production of reversible damage of the skin following the application of a test substance for up to 4 hours.
Dermal corrosion: is the production of irreversible damage of the skin; namely, visible necrosis through the epidermis and into the dermis, following the application of a test substance for up to four hours. Corrosive reactions are typified by ulcers, bleeding, bloody scabs, and, by the end of observation at 14 days, by discoloration due to blanching of the skin, complete areas of alopecia, and scars. Histopathology should be considered to evaluate questionable lesions.

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Source: https://www.legislation.gov.uk/eudr/2004/73/annex/n5/division/B/division/1/division/1.2 (the official version)
Page: https://openlegislation.uk/eu-directive-2004-73/annex-n5/division-B/division-1/division-1.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.