# Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance), Division 1.4.2.5: Observation period

Extent: E+W+S+N.I.

The duration of the observation period should be sufficient to evaluate fully the reversibility of the effects observed. However, the experiment should be terminated at any time that the animal shows continuing signs of severe pain or distress. To determine the reversibility of effects, the animals should be observed up to 14 days after removal of the patches. If reversibility is seen before 14 days, the experiment should be terminated at that time.

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Source: https://www.legislation.gov.uk/eudr/2004/73/annex/n5/division/B/division/1/division/1.4/division/1.4.2/division/1.4.2.5 (the official version)
Page: https://openlegislation.uk/eu-directive-2004-73/annex-n5/division-B/division-1/division-1.4/division-1.4.2/division-1.4.2.5
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.