# Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the twenty-ninth time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances (Text with EEA relevance), Division 1.5.7: Organ weights

Extent: E+W+S+N.I.

At the time of termination, body weight and the weight of the following organs of all P and F1 parental animals shall be determined (paired organs should be weighed individually):
Uterus, ovaries;
Testes, epididymides (total and cauda);
Prostate;
Seminal vesicles with coagulating glands and their fluids and prostate (as one unit);
Brain, liver, kidneys, spleen, pituitary, thyroid and adrenal glands and known target organs.
Terminal body weights should be determined for F1 and F2 pups that are selected for necropsy. The following organs from the one randomly selected pup/sex/litter (see section 1.5.6) shall be weighed: Brain, spleen and thymus.
Gross necropsy and organ weight results should be assessed in context with observations made in other repeated dose studies, when feasible.

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Source: https://www.legislation.gov.uk/eudr/2004/73/annex/n8/division/B.35/division/1/division/1.5/division/1.5.7 (the official version)
Page: https://openlegislation.uk/eu-directive-2004-73/annex-n8/division-B.35/division-1/division-1.5/division-1.5.7
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.