# Council Directive 2005/25/EC of 14 March 2005 amending Annex VI to Directive 91/414/EEC as regards plant protection products containing micro-organisms (Text with EEA relevance), Division 2.2.1.3: The mode of action of the micro-organism should be evaluated in as much detail as appropriate. The possible role of metabolites/toxins for the mode of action should be evaluated and when identified, the minimal effective concentration for each active metabolite/toxin should be established. Information on mode of action can be a very valuable tool in identifying potential risks. Aspects to be considered in the evaluation, are:

Extent: E+W+S+N.I.

(a) antibiosis,
(b) induction of plant resistance,
(c) interference with the virulence of a pathogenic target organism,
(d) endophytic growth,
(e) root colonisation,
(f) competition of ecological niche (e.g. nutrients, habitats),
(g) parasitisation,
(h) invertebrate pathogenicity.

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Source: https://www.legislation.gov.uk/eudr/2005/25/annex/division/B/division/2/division/2.2/division/2.2.1/division/2.2.1.3 (the official version)
Page: https://openlegislation.uk/eu-directive-2005-25/annex/division-B/division-2/division-2.2/division-2.2.1/division-2.2.1.3
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.