{
  "url": "https://openlegislation.uk/eu-directive-2019-1833/annex/division-2",
  "json_url": "https://openlegislation.uk/eu-directive-2019-1833/annex/division-2.json",
  "legislation": "eudr/2019/1833",
  "legislation_title": "Commission Directive (EU) 2019/1833 of 24 October 2019 amending Annexes I, III, V and VI to Directive 2000/54/EC of the European Parliament and of the Council as regards purely technical adjustments",
  "legislation_url": "https://openlegislation.uk/eu-directive-2019-1833",
  "path": "annex/division/2",
  "kind": "division",
  "number": "(2)",
  "heading": "Annex III to Directive 2000/54/EC is replaced by the following:",
  "text": "‘ANNEX III\nCOMMUNITY CLASSIFICATION\nArticle 2, second paragraph, and Article 18\nINTRODUCTORY NOTES\n1.\nIn line with the scope of the Directive, only agents which are known to infect humans are to be included in the classified list.\nWhere appropriate, indicators are given of the toxic and allergic potential of these agents.\nAnimal and plant pathogens which are known not to affect man are excluded.\nIn drawing up this list of classified biological agents consideration has not been given to genetically modified micro-organisms.\n2.\nThe list of classified agents is based on the effect of those agents on healthy workers.\nNo specific account is taken of particular effects on those whose susceptibility may be affected for one or other reason such as pre-existing disease, medication, compromised immunity, pregnancy or breast feeding.\nAdditional risk to such workers should be considered as part of the risk assessment required by the Directive.\nIn certain industrial processes, certain laboratory work or certain work with animals involving actual or potential exposure to biological agents of groups 3 or 4, any technical precautions taken must comply with Article 16 of the Directive.\n3.\nBiological agents which have not been classified for inclusion in groups 2 to 4 of the list are not implicitly classified in group 1.\nFor genera where more than one species is known to be pathogenic to man, the list will include those species which are known to be the most frequently responsible for diseases, together with a more general reference to the fact that other species of the same genus may affect health.\nWhen a whole genus is mentioned in the classified list of biological agents, it is implicit that the species and strains known to be non-pathogenic are excluded.\n4.\nWhere a strain is attenuated or has lost known virulence genes, then the containment required by the classification of its parent strain need not necessarily apply, subject to assessment appropriate for risk in the workplace.\nThis is the case, for example, when such a strain is to be used as a product or part of a product for prophylactic or therapeutic purposes.\n5.\nThe nomenclature of classified agents used to establish this list reflects and is in conformity with the latest international agreements of the taxonomy and nomenclature of agents at the time the list was prepared.\n6.\nThe list of classified biological agents reflects the state of knowledge at the time that it was devised.\nIt will be updated as soon as it no longer reflects the latest state of knowledge.\n7.\nMember States are to ensure that all viruses which have already been isolated in humans and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.\n8.\nCertain biological agents classified in group 3 which are indicated in the appended list by two asterisks (**), may present a limited risk of infection for workers because they are not normally infectious by the airborne route.\nMember States shall assess the containment measures to be applied to such agents, taking account of the nature of specific activities in question and of the quantity of the agent involved, with a view to determining whether, in particular circumstances, some of these measures may be dispensed with.\n9.\nThe requirements as to containment consequent on the classification of parasites apply only to stages in the life cycle of the parasite in which it is liable to be infectious to humans at the workplace.\n10.\nThis list also gives a separate indication in cases where the biological agents are likely to cause allergic or toxic reactions, where an effective vaccine is available, or where it is advisable to keep a list of exposed workers for more than 10 years.\nThese indications are shown by the following letters:\nA:: Possible allergic effects\nD:: List of workers exposed to this biological agent to be kept for more than 10 years after the end of last known exposure\nT:: Toxin production\nV:: Effective vaccine available and registered within the EU\nThe application of preventive vaccination should take account of the code of practice given in Annex VII.\nBACTERIA\nand similar organisms\nNB: For biological agents appearing on this list, the entry of the whole genus with the addition of “spp.” refers to other species belonging to this genus that have not specifically been included in the list, but which are known pathogens in humans. See introductory note 3 for further details.\nSee paragraph 8 of the introductory notes.\nBiological agent\nClassification\nNotes\nActinomadura madurae\nW\nActinomadura pelletieri\n2\nActinomyces gerencseriae\n2\nActinomyces israelii\n2\nActinomyces spp.\n2\nAggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans)\n2\nAnaplasma spp.\n2\nArcanobacterium haemolyticum (Corynebacterium haenolyticum)\n2\nArcobacter butzleri\n2\nBacillus anthracis\n3\nT\nBacteroides fragilis\n2\nBacteroides spp.\n2\nBartonella bacilliformis\n2\nBartonella quintana (Rochalimaea quintana)\n2\nBartonella (Rochalimaea) spp.\n2\nBordetella bronchiseptica\n2\nBordetella parapertussis\n2\nBordetella pertussis\n2\nT, V\nBordetella spp.\n2\nBorrelia burgdorferi\n2\nBorrelia duttonii\n2\nBorrelia recurrentis\n2\nBorrelia spp.\n2\nBrachyspira spp.\n2\nBrucella abortus\n3\nBrucella canis\n3\nBrucella inopinata\n3\nBrucella melitensis\n3\nBrucella suis\n3\nBurkholderia cepacia\n2\nBurkholderia mallei (Pseudomonas mallei)\n3\nBurkholderia pseudomallei (Pseudomonas pseudomallei)\n3\nD\nCampylobacter fetus subsp. fetus\n2\nCampylobacter fetus subsp. venerealis\n2\nCampylobacter jejuni subsp. doylei\n2\nCampylobacter jejuni subsp. jejuni\n2\nCampylobacter spp.\n2\nCardiobacterium hominis\n2\nCardiobacterium valvarum\n2\nChlamydia abortus (Chlamydophila abortus)\n2\nChlamydia caviae (Chlamydophila caviae)\n2\nChlamydia felis (Chlamydophila felis)\n2\nChlamydia pneumoniae (Chlamydophila pneumoniae)\n2\nChlamydia psittaci (Chlamydophila psittaci) (avian strains)\n3\nChlamydia psittaci (Chlamydophila psittaci) (other strains)\n2\nChlamydia trachomatis (Chlamydophila trachomatis)\n2\nClostridium botulinum\n2\nT\nClostridium difficile\n2\nT\nClostridium perfringens\n2\nT\nClostridium tetani\n2\nT, V\nClostridium spp.\n2\nCorynebacterium diphtheriae\n2\nT, V\nCorynebacterium minutissimum\n2\nCorynebacterium pseudotuberculosis\n2\nT\nCorynebacterium ulcerans\n2\nT\nCorynebacterium spp.\n2\nCoxiella burnetii\n3\nEdwardsiella tarda\n2\nEhrlichia spp.\n2\nEikenella corrodens\n2\nElizabethkingia meningoseptica (Flavobacterium meningosepticum)\n2\nEnterobacter aerogenes (Klebsiella mobilis)\n2\nEnterobacter cloacae subsp. cloacae (Enterobacter cloacae)\n2\nEnterobacter spp.\n2\nEnterococcus spp.\n2\nErysipelothrix rhusiopathiae\n2\nEscherichia coli (with the exception of non-pathogenic strains)\n2\nEscherichia coli, verocytotoxigenic strains (e.g. O157:H7 or O103)\n3\nT\nFluoribacter bozemanae (Legionella)\n2\nFrancisella hispaniensis\n2\nFrancisella tularensis subsp. holarctica\n2\nFrancisella tularensis subsp. mediasiatica\n2\nFrancisella tularensis subsp. novicida\n2\nFrancisella tularensis subsp. tularensis\n3\nFusobacterium necrophorum subsp. funduliforme\n2\nFusobacterium necrophorum subsp. necrophorum\n2\nGardnerella vaginalis\n2\nHaemophilus ducreyi\n2\nHaemophilus influenzae\n2\nV\nHaemophilus spp.\n2\nHelicobacter pylori\n2\nHelicobacter spp.\n2\nKlebsiella oxytoca\n2\nKlebsiella pneumoniae subsp. ozaenae\n2\nKlebsiella pneumoniae subsp. pneumoniae\n2\nKlebsiella pneumoniae subsp. rhinoscleromatis\n2\nKlebsiella spp.\n2\nLegionella pneumophila subsp. fraseri\n2\nLegionella pneumophila subsp. pascullei\n2\nLegionella pneumophila subsp. pneumophila\n2\nLegionella spp.\n2\nLeptospira interrogans (all serovars)\n2\nLeptospira interrogans spp.\n2\nListeria monocytogenes\n2\nListeria ivanovii subsp. ivanovii\n2\nListeria invanovii subsp. londoniensis\n2\nMorganella morganii subsp. morganii (Proteus morganii)\n2\nMorganella morganii subsp. sibonii\n2\nMycobacterium abscessus subsp. abscessus\n2\nMycobacterium africanum\n3\nV\nMycobacterium avium subsp. avium (Mycobacterium avium)\n2\nMycobacterium avium subsp. paratuberculosis (Mycobacterium paratuberculosis)\n2\nMycobacterium avium subsp. silvaticum\n2\nMycobacterium bovis\n3\nV\nMycobacterium caprae (Mycobacterium tuberculosis subsp. caprae)\n3\nMycobacterium chelonae\n2\nMycobacterium chimaera\n2\nMycobacterium fortuitum\n2\nMycobacterium intracellulare\n2\nMycobacterium kansasii\n2\nMycobacterium leprae\n3\nMycobacterium malmoense\n2\nMycobacterium marinum\n2\nMycobacterium microti\n3\nMycobacterium pinnipedii\n3\nMycobacterium scrofulaceum\n2\nMycobacterium simiae\n2\nMycobacterium szulgai\n2\nMycobacterium tuberculosis\n3\nV\nMycobacterium ulcerans\n3\nMycobacterium xenopi\n2\nMycoplasma hominis\n2\nMycoplasma pneumoniae\n2\nMycoplasma spp.\n2\nNeisseria gonorrhoeae\n2\nNeisseria meningitidis\n2\nV\nNeorickettsia sennetsu (Rickettsia sennetsu, Ehrlichia sennetsu)\n2\nNocardia asteroides\n2\nNocardia brasiliensis\n2\nNocardia farcinica\n2\nNocardia nova\n2\nNocardia otitidiscaviarum\n2\nNocardia spp.\n2\nOrientia tsutsugamushi (Rickettsia tsutsugamushi)\n3\nPasteurella multocida subsp. gallicida (Pasteurella gallicida)\n2\nPasteurella multocida subsp. multocida\n2\nPasteurella multocida subsp. septica\n2\nPasteurella spp.\n2\nPeptostreptococcus anaerobius\n2\nPlesiomonas shigelloides\n2\nPorphyromonas spp.\n2\nPrevotella spp.\n2\nProteus mirabilis\n2\nProteus penneri\n2\nProteus vulgaris\n2\nProvidencia alcalifaciens (Proteus inconstans)\n2\nProvidencia rettgeri (Proteus rettgeri)\n2\nProvidencia spp.\n2\nPseudomonas aeruginosa\n2\nT\nRhodococcus hoagii (Corynebacterium equii)\n2\nRickettsia africae\n3\nRickettsia akari\n3\nRickettsia australis\n3\nRickettsia canadensis\n2\nRickettsia conorii\n3\nRickettsia heilongjiangensis\n3\nRickettsia japonica\n3\nRickettsia montanensis\n2\nRickettsia typhi\n3\nRickettsia prowazekii\n3\nRickettsia rickettsii\n3\nRickettsia sibirica\n3\nRickettsia spp.\n2\nSalmonella enterica (choleraesuis) subsp. arizonae\n2\nSalmonella Enteritidis\n2\nSalmonella Paratyphi A, B, C\n2\nV\nSalmonella Typhi\n3\nV\nSalmonella Typhimurium\n2\nSalmonella (other serovars)\n2\nShigella boydii\n2\nShigella dysenteriae (Type 1)\n3\nT\nShigella dysenteriae, other than Type 1\n2\nShigella flexneri\n2\nShigella sonnei\n2\nStaphylococcus aureus\n2\nT\nStreptobacillus moniliformis\n2\nStreptococcus agalactiae\n2\nStreptococcus dysgalactiae subsp. equisimilis\n2\nStreptococcus pneumoniae\n2\nT, V\nStreptococcus pyogenes\n2\nT\nStreptococcus suis\n2\nStreptococcus spp.\n2\nTreponema carateum\n2\nTreponema pallidum\n2\nTreponema pertenue\n2\nTreponema spp.\n2\nTrueperella pyogenes\n2\nUreaplasma parvum\n2\nUreaplasma urealyticum\n2\nVibrio cholerae (including El Tor)\n2\nT, V\nVibrio parahaemolyticus (Benecka parahaemolytica)\n2\nVibrio spp.\n2\nYersinia enterocolitica subsp. enterolitica\n2\nYersinia enterocolitica subsp. palearctica\n2\nYersinia pestis\n3\nYersinia pseudotuberculosis\n2\nYersinia spp.\n2\nVIRUSES (*)\nSee paragraph 7 of the introductory notes.\nNB: Viruses have been listed according to their order (O), family (F) and genus (G).\nSee paragraph 7 of the introductory notes.\nClassification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use.\nSee paragraph 8 of the introductory notes.\nTick-borne encephalitis.\nHepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus.\nOnly for types A and B.\nRecommended for work involving direct contact with these agents.\nTwo viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus.\nVariant of cowpox virus.\nVariant of Vaccinia.\nAt present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them.\nBiological agent(virus species or indicated taxonomy order)\nClassification\nNotes\nBunyavirales (O)\nHantaviridae (F)\nOrthohantavirus (G)\nAndes orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])\n3\nBayou orthohantavirus\n3\nBlack Creek Canal orthohantavirus\n3\nCano Delgadito orthohantavirus\n3\nChoclo orthohantavirus\n3\nDobrava-Belgrade orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])\n3\nEl Moro Canyon orthohantavirus\n3\nHantaan orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])\n3\nLaguna Negra orthohantavirus\n3\nProspect Hill orthohantavirus\n2\nPuumala orthohantavirus (Hantavirus species causing Nephropathia Epidemica [NE])\n2\nSeoul orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])\n3\nSin Nombre orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])\n3\nOther hantaviruses known to be pathogenic\n2\nNairoviridae (F)\nOrthonairovirus (G)\nCrimean-Congo haemorrhagic fever orthonairovirus\n4\nDugbe orthonairovirus\n2\nHazara orthonairovirus\n2\nNairobi sheep disease orthonairovirus\n2\nOther nairoviruses known to be pathogenic\n2\nPeribunyaviridae (F)\nOrthobunyavirus (G)\nBunyamwera orthobunyavirus (Germiston virus)\n2\nCalifornia encephalitis orthobunyavirus\n2\nOropouche orthobunyavirus\n3\nOther orthobunyaviruses known to be pathogenic\n2\nPhenuiviridae (F)\nPhlebovirus (G)\nBhanja phlebovirus\n2\nPunta Toro phlebovirus\n2\nRift Valley fever phlebovirus\n3\nSandfly fever Naples phlebovirus (Toscana Virus)\n2\nSFTS phlebovirus (Severe Fever with Thrombocytopenia Syndrome-Virus)\n3\nOther phleboviruses known to be pathogenic\n2\nHerpesvirales (O)\nHerpesviridae (F)\nCytomegalovirus (G)\nHuman betaherpesvirus 5 (Cytomegalovirus)\n2\nLymphocryptovirus (G)\nHuman gammaherpesvirus 4 (Epstein-Barr virus)\n2\nRhadinoovirus (G)\nHuman gammaherpesvirus 8\n2\nD\nRoseolovirus (G)\nHuman betaherpesvirus 6A (Human B-lymphotropic virus)\n2\nHuman betaherpesvirus 6B\n2\nHuman betaherpesvirus 7\n2\nSimplexvirus (G)\nMacacine alphaherpesvirus 1 (Herpesvirus simiae, Herpes B virus)\n3\nHuman alphaherpesvirus 1 (Human herpesvirus 1, Herpes simplex virus type 1)\n2\nHuman alphaherpesvirus 2 (Human herpesvirus 2, Herpes simplex virus type 2)\n2\nVaricellovirus (G)\nHuman alphaherpesvirus 3 (Herpesvirus varicella-zoster)\n2\nV\nMononegavirales (O)\nFiloviridae (F)\nEbolavirus (G)\n4\nMarburgvirus (G)\nMarburg marburgvirus\n4\nParamyxoviridae (F)\nAvulavirus (G)\nNewcastle disease virus\n2\nHenipavirus (G)\nHendra henipavirus\n4\nNipah henipavirus\n4\nMorbillivirus (G)\nMeasles morbillivirus\n2\nV\nRespirovirus (G)\nHuman respirovirus 1 (Parainfluenza virus 1)\n2\nHuman respirovirus 3 (Parainfluenza virus 3)\n2\nRubulavirus (G)\nMumps rubulavirus\n2\nV\nHuman rubulavirus 2 (Parainfluenza virus 2)\n2\nHuman rubulavirus 4 (Parainfluenza virus 4)\n2\nPneumoviridae (F)\nMetapneumovirus (G)\nOrthopneumovirus (G)\nHuman orthopneumovirus (Respiratory syncytial virus)\n2\nRhabdoviridae (F)\nLyssavirus (G)\nAustralian bat lyssavirus\n3\nV\nDuvenhage lyssavirus\n3\nV\nEuropean bat lyssavirus 1\n3\nV\nEuropean bat lyssavirus 2\n3\nV\nLagos bat lyssavirus\n3\nMokola lyssavirus\n3\nRabies lyssavirus\n3\nV\nVesiculovirus (G)\nVesicular stomatitis virus, Alagoas vesiculovirus\n2\nVesicular stomatitis virus, Indiana vesiculovirus\n2\nVesicular stomatitis virus, New Jersey vesiculovirus\n2\nPiry vesiculovirus (Piry virus)\n2\nNidovirales (O)\nCoronaviridae (F)\nBetacoronavirus (G)\nSevere acute respiratory syndrome-related coronavirus (SARS-virus)\n3\nMiddle East respiratory syndrome coronavirus (MERS-virus)\n3\nOther Coronaviridae known to be pathogenic\n2\nPicornavirales (O)\nPicornaviridae (F)\nCardiovirus (G)\nSaffold virus\n2\nCosavirus (G)\nCosavirus A\n2\nEnterovirus (G)\nEnterovirus A\n2\nEnterovirus B\n2\nEnterovirus C\n2\nEnterovirus D, Human Enterovirus type 70 (Acute haemorrhagic conjunctivitis virus)\n2\nRhinoviruses\n2\nPoliovirus, type 1 and 3\n2\nV\nPoliovirus, type 2\n3\nV\nHepatovirus (G)\nHepatovirus A (Hepatitis A virus, Human Enterovirus type 72)\n2\nV\nKobuvirus (G)\nAichivirus A (Aichi virus 1)\n2\nParechovirus (G)\nParechoviruses A\n2\nParechoviruses B (Ljungan virus)\n2\nOther Picornaviridae known to be pathogenic\n2\nUnassigned (O)\nAdenoviridae (F)\n2\nAstroviridae (F)\n2\nArenaviridae (F)\nMammarenavirus (G)\nBrazilian mammarenavirus\n4\nChapare mammarenavirus\n4\nFlexal mammarenavirus\n3\nGuanarito mammarenavirus\n4\nJunín mammarenavirus\n4\nLassa mammarenavirus\n4\nLujo mammarenavirus\n4\nLymphocytic choriomeningitis mammarenavirus, neurotropic strains\n2\nLymphocytic choriomeningitis mammarenavirus (other strains)\n2\nMachupo mammarenavirus\n4\nMobala mammarenavirus\n2\nMopeia mammarenavirus\n2\nTacaribe mammarenavirus\n2\nWhitewater Arroyo mammarenavirus\n3\nCaliciviridae (F)\nNorovirus (G)\nNorovirus (Norwalk virus)\n2\nOther Caliciviridae known to be pathogenic\n2\nHepadnaviridae (F)\nOrthohepadnavirus (G)\nHepatitis B virus\n3\nV, D\nHepeviridae (F)\nOrthohepevirus (G)\nOrthohepevirus A (Hepatitis E virus)\n2\nFlaviviridae (F)\nFlavivirus (G)\nDengue virus\n3\nJapanese encephalitis virus\n3\nV\nKyasanur Forest disease virus\n3\nV\nLouping ill virus\n3\nMurray Valley encephalitis virus (Australia encephalitis virus)\n3\nOmsk haemorrhagic fever virus\n3\nPowassan virus\n3\nRocio virus\n3\nSt. Louis encephalitis virus\n3\nTick-borne encephalitis virus\nAbsettarov virus\n3\nHanzalova virus\n3\nHypr virus\n3\nKumlinge virus\n3\nNegishi virus\n3\nRussian spring-summer encephalitis\n3\nV\nTick-borne encephalitis virus Central European subtype\n3\nV\nTick-borne encephalitis virus Far Eastern Subtype\n3\nTick-borne encephalitis virus Siberian subtype\n3\nV\nWesselsbron virus\n3\nWest Nile fever virus\n3\nYellow fever virus\n3\nV\nZika virus\n2\nOther flaviviruses known to be pathogenic\n2\nHepacivirus (G)\nHepacivirus C (Hepatitis C virus)\n3\nD\nOrthomyxoviridae (F)\nGammainfluenzavirus (G)\nInfluenza C virus\n2\nV\nInfluenzavirus A (G)\nHighly Pathogenic Avian Influenza Viruses HPAIV (H5), e.g. H5N1\n3\nHighly Pathogenic Avian Influenza Viruses HPAIV (H7), e.g. H7N7, H7N9\n3\nInfluenza A virus\n2\nV\nInfluenza A virus A/New York/1/18 (H1N1) (Spanish flu 1918)\n3\nInfluenza A virus A/Singapore/1/57 (H2N2)\n3\nLow Pathogenic Avian Influenza Virus (LPAI) H7N9\n3\nInfluenzavirus B (G)\nInfluenza B virus\n2\nV\nThogoto virus (G)\nDhori virus (Tick-borne orthomyxoviridae: Dhori)\n2\nThogoto virus (Tick-borne orthomyxoviridae: Thogoto)\n2\nPapillomaviridae (F)\n2\nD\nParvoviridae (F)\nErythroparvovirus (G)\nPrimate erythroparvovirus 1 (Human parvovirus, B 19 virus)\n2\nPolyomaviridae (F)\nBetapolyomavirus (G)\nHuman polyomavirus 1 (BK virus)\n2\nD\nHuman polyomavirus 2 (JC virus)\n2\nD\nPoxviridae (F)\nMolluscipoxvirus (G)\nMolluscum contagiosum virus\n2\nOrthopoxvirus (G)\nCowpox virus\n2\nMonkeypox virus\n3\nV\nVaccinia virus (incl. Buffalopox virus, Elephantpox virus, Rabbitpox virus)\n2\nVariola (major and minor) virus\n4\nV\nParapoxvirus (G)\nOrf virus\n2\nPseudocowpox virus (Milkers’ node virus, parapoxvirus bovis)\n2\nYatapoxvirus (G)\nTanapox virus\n2\nYaba monkey tumor virus\n2\nReoviridae (F)\nSeadornavirus (G)\nBanna virus\n2\nColtivirus (G)\n2\nRotaviruses (G)\n2\nOrbivirus (G)\n2\nRetroviridae (F)\nDeltaretrovirus (G)\nPrimate T-lymphotropic virus 1 (Human T-cell lymphotropic virus, type 1)\n3\nD\nPrimate T-lymphotropic virus 2 (Human T-cell lymphotropic virus, type 2)\n3\nD\nLentivirus (G)\nHuman immunodeficiency virus 1\n3\nD\nHuman immunodeficiency virus 2\n3\nD\nSimian Immunodeficiency Virus (SIV)\n2\nTogaviridae (F)\nAlphavirus (G)\nCabassouvirus\n3\nEastern equine encephalomyelitis virus\n3\nV\nBebaru virus\n2\nChikungunya virus\n3\nEverglades virus\n3\nMayaro virus\n3\nMucambo virus\n3\nNdumu virus\n3\nO’nyong-nyong virus\n2\nRoss River virus\n2\nSemliki Forest virus\n2\nSindbis virus\n2\nTonate virus\n3\nVenezuelan equine encephalomyelitis virus\n3\nV\nWestern equine encephalomyelitis virus\n3\nV\nOther alphaviruses known to be pathogenic\n2\nRubivirus (G)\nRubella virus\n2\nV\nUnassigned (F)\nDeltavirus (G)\nHepatitis delta virus\n2\nV, D\nPRION DISEASE AGENTS\nSee paragraph 8 of the introductory notes.\nRecommended for work involving direct contact with these agents.\nBiological agent\nClassification\nNotes\nAgent of Creutzfeldt-Jakob disease\n3\nD\nVariant Agent of Creutzfeldt-Jakob disease\n3\nD\nAgent of Bovine Spongiform Encephalopathy (BSE) and other related animal TSEs\n3\nD\nAgent of Gerstmann-Sträussler-Scheinker syndrome\n3\nD\nAgent of Kuru\n3\nD\nAgent of Scrapie\n2\nPARASITES\nNB: For biological agents appearing on this list, the entry of the whole genus with the addition of “spp.” refers to other species belonging to this genus that have not specifically been included in the list, but which are known pathogens in humans. See introductory note 3 for further details.\nSee paragraph 8 of the introductory notes.\nBiological agent\nClassification\nNotes\nAcanthamoeba castellani\n2\nAncylostoma duodenale\n2\nAngiostrongylus cantonensis\n2\nAngiostrongylus costaricensis\n2\nAnisakis simplex\n2\nA\nAscaris lumbricoides\n2\nA\nAscaris suum\n2\nA\nBabesia divergens\n2\nBabesia microti\n2\nBalamuthia mandrillaris\n3\nBalantidium coli\n2\nBrugia malayi\n2\nBrugia pahangi\n2\nBrugia timori\n2\nCapillaria philippinensis\n2\nCapillaria spp.\n2\nClonorchis sinensis (Opisthorchis sinensis)\n2\nClonorchis viverrini (Opisthirchis viverrini)\n2\nCryptosporidium hominis\n2\nCryptosporidium parvum\n2\nCyclospora cayetanensis\n2\nDicrocoelium dentriticum\n2\nDipetalonema streptocerca\n2\nDiphyllobothrium latum\n2\nDracunculus medinensis\n2\nEchinococcus granulosus\n3\nEchinococcus multilocularis\n3\nEchinococcus oligarthrus\n3\nEchinococcus vogeli\n3\nEntamoeba histolytica\n2\nEnterobius vermicularis\n2\nEnterocytozoon bieneusi\n2\nFasciola gigantica\n2\nFasciola hepatica\n2\nFasciolopsis buski\n2\nGiardia lamblia (Giardia duodenalis, Giardia intestinalis)\n2\nHeterophyes spp.\n2\nHymenolepis diminuta\n2\nHymenolepis nana\n2\nLeishmania aethiopica\n2\nLeishmania braziliensis\n3\nLeishmania donovani\n3\nLeishmania guyanensis (Viannia guyanensis)\n3\nLeishmania infantum (Leishmania chagasi)\n3\nLeishmania major\n2\nLeishmania mexicana\n2\nLeishmania panamensis (Viannia panamensis)\n3\nLeishmania peruviana\n2\nLeishmania tropica\n2\nLeishmania spp.\n2\nLoa loa\n2\nMansonella ozzardi\n2\nMansonella perstans\n2\nMansonella streptocerca\n2\nMetagonimus spp.\n2\nNaegleria fowleri\n3\nNecator americanus\n2\nOnchocerca volvulus\n2\nOpisthorchis felineus\n2\nOpisthorchis spp.\n2\nParagonimus westermani\n2\nParagonimus spp.\n2\nPlasmodium falciparum\n3\nPlasmodium knowlesi\n3\nPlasmodium spp. (human and simian)\n2\nSarcocystis suihominis\n2\nSchistosoma haematobium\n2\nSchistosoma intercalatum\n2\nSchistosoma japonicum\n2\nSchistosoma mansoni\n2\nSchistosoma mekongi\n2\nStrongyloides stercoralis\n2\nStrongyloides spp.\n2\nTaenia saginata\n2\nTaenia solium\n3\nToxocara canis\n2\nToxocara cati\n2\nToxoplasma gondii\n2\nTrichinella nativa\n2\nTrichinella nelsoni\n2\nTrichinella pseudospiralis\n2\nTrichinella spiralis\n2\nTrichomonas vaginalis\n2\nTrichostrongylus orientalis\n2\nTrichostrongylus spp.\n2\nTrichuris trichiura\n2\nTrypanosoma brucei brucei\n2\nTrypanosoma brucei gambiense\n2\nTrypanosoma brucei rhodesiense\n3\nTrypanosoma cruzi\n3\nWuchereria bancrofti\n2\nFUNGI\nNB: For biological agents appearing on this list, the entry of the whole genus with the addition of “spp.” refers to other species belonging to this genus that have not specifically been included in the list, but which are known pathogens in humans. See introductory note 3 for further details.\nBiological agent\nClassification\nNotes\nAspergillus flavus\n2\nA\nAspergillus fumigatus\n2\nA\nAspergillus spp.\n2\nBlastomyces dermatitidis (Ajellomyces dermatitidis)\n3\nBlastomyces gilchristii\n3\nCandida albicans\n2\nA\nCandida dubliniensis\n2\nCandida glabrata\n2\nCandida parapsilosis\n2\nCandida tropicalis\n2\nCladophialophora bantiana (Xylohypha bantiana, Cladosporium bantianum, trichoides)\n3\nCladophialophora modesta\n3\nCladophialophora spp.\n2\nCoccidioides immitis\n3\nA\nCoccidioides posadasii\n3\nA\nCryptococcus gattii (Filobasidiella neoformans var. bacillispora)\n2\nA\nCryptococcus neoformans (Filobasidiella neoformans var. neoformans)\n2\nA\nEmmonsia parva var. parva\n2\nEmmonsia parva var. crescens\n2\nEpidermophyton floccosum\n2\nA\nEpidermophyton spp.\n2\nFonsecaea pedrosoi\n2\nHistoplasma capsulatum\n3\nHistoplasma capsulatum var. farciminosum\n3\nHistoplasma duboisii\n3\nMadurella grisea\n2\nMadurella mycetomatis\n2\nMicrosporum spp.\n2\nA\nNannizzia spp.\n2\nNeotestudina rosatii\n2\nParacoccidioides brasiliensis\n3\nA\nParacoccidioides lutzii\n3\nParaphyton spp.\n2\nRhinocladiella mackenziei\n3\nScedosporium apiospermum\n2\nScedosporium prolificans (inflatum)\n2\nSporothrix schenckii\n2\nTalaromyces marneffei (Penicillium marneffei)\n2\nA\nTrichophyton rubrum\n2\nA\nTrichophyton tonsurans\n2\nA\nTrichophyton spp.\n2\n’",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "footnote",
      "label": "f1",
      "text": "See paragraph 8 of the introductory notes."
    },
    {
      "type": "footnote",
      "label": "f2",
      "text": "See paragraph 7 of the introductory notes."
    },
    {
      "type": "footnote",
      "label": "f3",
      "text": "See paragraph 8 of the introductory notes."
    },
    {
      "type": "footnote",
      "label": "f4",
      "text": "Classification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use."
    },
    {
      "type": "footnote",
      "label": "f5",
      "text": "Tick-borne encephalitis."
    },
    {
      "type": "footnote",
      "label": "f6",
      "text": "Only for types A and B."
    },
    {
      "type": "footnote",
      "label": "f7",
      "text": "Recommended for work involving direct contact with these agents."
    },
    {
      "type": "footnote",
      "label": "f8",
      "text": "Two viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus."
    },
    {
      "type": "footnote",
      "label": "f9",
      "text": "Variant of cowpox virus."
    },
    {
      "type": "footnote",
      "label": "f10",
      "text": "Variant of Vaccinia."
    },
    {
      "type": "footnote",
      "label": "f11",
      "text": "At present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them."
    },
    {
      "type": "footnote",
      "label": "f12",
      "text": "Hepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus."
    },
    {
      "type": "footnote",
      "label": "f13",
      "text": "See paragraph 8 of the introductory notes."
    },
    {
      "type": "footnote",
      "label": "f14",
      "text": "Recommended for work involving direct contact with these agents."
    },
    {
      "type": "footnote",
      "label": "f15",
      "text": "See paragraph 8 of the introductory notes."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eudr/2019/1833/annex/division/2",
    "retrieved_at": "2026-11-01T15:21:25.411818+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}