{
  "url": "https://openlegislation.uk/eu-regulation-2005-111/annex",
  "json_url": "https://openlegislation.uk/eu-regulation-2005-111/annex.json",
  "legislation": "eur/2005/111",
  "legislation_title": "Council Regulation (EC) No 111/2005 of 22 December 2004 laying down rules for the monitoring of trade between the Union and third countries in drug precursors",
  "legislation_url": "https://openlegislation.uk/eu-regulation-2005-111",
  "path": "annex",
  "kind": "annex",
  "number": null,
  "heading": null,
  "text": "List of scheduled substances\nCategory 1\nSubstance\nCN designation(if different)\nCN Code\nCAS No\n(1)OJ No. L 290, 28.10.2002, p. 1.\n(2)The CAS No is the ‘Chemical abstracts service registry number’, which is a unique numeric identifier specific to each substance and its structure. The CAS No is specific to each isomer and to each salt of each isomer. The CAS Nos for the salts of the substances listed above will be different from those given.\n(3)Also named (+)-norpseudoephedrine, CN code 2939 43 00, CAS No 492-39-7.\n(4)Also known as ethyl 3-oxo-2-phenylbutanoate, according to The International Union of Pure and Applied Chemistry (IUPAC).\n(5)Also known as methyl 2-(2H-1,3-benzodioxol-5-yl)-3-oxobutanoate, according to IUPAC.\n(6)And its ethyl, methyl (CAS No 80532-66-7), propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl esters, with the same CN code as BMK glycidic acid.\n(7)And its ethyl (CAS No 28578-16-7), methyl (CAS No 13605-48-6), propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl esters, with the same CN code as PMK glycidic acid.\n(8)Also known as 5-[2-(1,3-benzodioxol-5-yl)acetyl]–2,2-dimethyl–1,3-dioxane–4,6-dione, according to IUPAC.\n1-Phenyl-2-propanone\nPhenylacetone\n2914 31 00\n103-79-7\nDiethyl (phenylacetyl) propanedioate (also referred to as DEPAPD)\n2918 30 00\n20320-59-6\nMethyl alpha-phenylacetoacetate (also referred to as MAPA)\n2918 30 00\n16648-44-5\nEthyl alpha-phenylacetoacetate (also referred to as EAPA)\nEx 2918 30 00\n5413-05-8\n2-methyl-3-phenyloxirane-2-carboxylic acid (also referred to as BMK glycidic acid)\n2918 99 90\n25547-51-7\nN-acetylanthranilic acid\n2-Acetamidobenzoic acid\n2924 23 00\n89-52-1\nAlpha-phenylacetoacetamide (also referred to as APAA)\n2924 29 70\n4433-77-6\nAlpha-phenylacetoacetonitrile (also referred to as APAAN)\n2926 40 00\n4468-48-8\nIsosafrol (cis+trans)\n2932 91 00\n120-58-1\n3,4-Methylenedioxyphenylpropan-2-one\n1-(1,3-Benzodioxol-5-yl)propan-2-one\n2932 92 00\n4676-39-5\nPiperonal\n2932 93 00\n120-57-0\nSafrole\n2932 94 00\n94-59-7\nMethyl 3-oxo-2-(3,4-methylenedioxyphenyl)butanoate (also referred to as MAMDPA)\nMethyl 3-oxo-2-(3,4-methylenedioxyphenyl)butanoate\nEx 2932 99 00\n1369021-80-6\n3-(1,3-benzodioxol-5-yl)-2-methyl-oxirane-2-carboxylic acid (also referred to as PMK glycidic acid)\n2932 99 00\n2167189-50-4\nIsopropylidene (2-(3,4-methylenedioxyphenyl)acetyl)malonate (also referred to as IMDPAM)\nIMDPAM\n2932 99 00\nN-phenyl-1-(2-phenylethyl)piperidin-4-amine\n4-anilino-N- phenethylpiperidine (ANPP)\n2933 36 00\n21409-26-7\n1-(2-phenylethyl)piperidin-4-one\nN-phenethyl-4-piperidone (NPP)\n2933 37 00\n39742-60-4\nN-phenylpiperidin-4-amine (also referred to as 4-AP)\n2933 39 99\n23056-29-3\nTert-butyl 4-anilinopiperidine-1-carboxylate (also referred to as 1-boc-4-AP)\n2933 39 99\n125541-22-2\nN-phenyl-N-(piperidin-4-yl)propanamide (also referred to as norfentanyl)\n2933 39 99\n1609-66-1\n4-piperidone\nPiperidin-4-one\n2933 39 99\n41661-47-6\n1-boc-4-piperidone\ntert-butyl 4-oxopiperidine-1-carboxylate\n2933 39 99\n79099-07-3\nEphedrine\n2939 41 00\n299-42-3\nPseudoephedrine\n2939 42 00\n90-82-4\nNorephedrine\n2939 44 00\n14838-15-4\nErgometrine\n2939 61 00\n60-79-7\nErgotamine\n2939 62 00\n113-15-5\nLysergic acid\n2939 63 00\n82-58-6\n(1R,2S)-(-)-chloroephedrine\n2939 79 90\n110925-64-9\n(1S,2R)-(+)-chloroephedrine\n2939 79 90\n1384199-95-4\n(1S,2S)-(+)-chloropseudoephedrine\n2939 79 90\n73393-61-0\n(1R,2R)-(-)-chloropseudoephedrine\n2939 79 90\n771434-80-1\nThe stereoisomeric forms of the substances listed in this Category not being cathine whenever the existence of such forms is possible.\nThe salts of the substances listed in this Category whenever the existence of such salts is possible and not being the salts of cathine.\nCategory 2\nSubstance\nCN designation (if different)\nCN Code\nCAS No\n(1)OJ No. L 290, 28.10.2002, p. 1.\n(2)The CAS No is the ‘Chemical abstracts service registry number’, which is a unique numeric identifier specific to each substance and its structure. The CAS No is specific to each isomer and to each salt of each isomer. The CAS Nos for the salts of the substances listed above will be different from those given.\nRed phosphorus\n2804 70 10\n7723-14-0\nAcetic anhydride\n2915 24 00\n108-24-7\nPhenylacetic acid\n2916 34 00\n103-82-2\nAnthranilic acid\n2922 43 00\n118-92-3\nPiperidine\n2933 32 00\n110-89-4\nPotassium permanganate\n2841 61 00\n7722-64-7\nThe salts of the substances listed in this Category whenever the existence of such salts is possible.\nCategory 3\nOJ L 290, 28.10.2002, p. 1.\nThe CAS No is the ‘Chemical abstracts service registry number’, which is a unique numeric identifier specific to each substance and its structure. The CAS No is specific to each isomer and to each salt of each isomer. It must be understood that the CAS Nos for the salts of the substances listed above will be different from those given.\nSubstance\nCN designation(if different)\nCN Code\nCAS No\nHydrochloric acid\nHydrogen chloride\n2806 10 00\n7647-01-0\nSulphuric acid\n2807 00 00\n7664-93-9\nToluene\n2902 30 00\n108-88-3\nEthyl ether\nDiethyl ether\n2909 11 00\n60-29-7\nAcetone\n2914 11 00\n67-64-1\nMethylethylketone\nButanone\n2914 12 00\n78-93-3\nThe salts of the substances listed in this Category whenever the existence of such salts is possible and not being the salts of hydrochloric acid and sulphuric acid.\nCategory 4\nSubstance\nCN designation (if different)\nCN Code\nMedicinal products and veterinary medicinal products containing ephedrine or its salts\nContaining ephedrine or its salts\n3003 41 00\n3004 41 00\nMedicinal products and veterinary medicinal products containing pseudo-ephedrine or its salts\nContaining pseudoephedrine (INN) or its salts\n3003 42 00\n3004 42 00",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "F",
      "label": "F1",
      "text": "Regulation revoked (N.I.) (29.6.2026) by The Controlled Drugs (Drug Precursors) (Amendment and Revocation) Regulations 2026 (S.I. 2026/607), reg. 1(1), Sch."
    },
    {
      "type": "F",
      "label": "F2",
      "text": "Substituted by Regulation (EU) No 1259/2013 of the European Parliament and of the Council of 20 November 2013 amending Council Regulation (EC) No 111/2005 laying down rules for the monitoring of trade between the Community and third countries in drug precursors."
    },
    {
      "type": "F",
      "label": "F3",
      "text": "Annex Table substituted (E.W.S.) (29.6.2026) by The Controlled Drugs (Drug Precursors) (Amendment and Revocation) Regulations 2026 (S.I. 2026/607), regs. 1(1), 6(24)(a)"
    },
    {
      "type": "F",
      "label": "F4",
      "text": "Annex Table substituted (29.6.2026) by The Controlled Drugs (Drug Precursors) (Amendment and Revocation) Regulations 2026 (S.I. 2026/607), regs. 1(1), 6(24)(b)"
    },
    {
      "type": "F",
      "label": "F5",
      "text": "Substituted by Commission Delegated Regulation (EU) 2020/1737 of 14 July 2020 amending Regulation (EC) No 273/2004 of the European Parliament and of the Council and Council Regulation (EC) No 111/2005 as regards the inclusion of certain drug precursors in the list of scheduled substances (Text with EEA relevance)."
    },
    {
      "type": "F",
      "label": "F6",
      "text": "Inserted by Regulation (EU) No 1259/2013 of the European Parliament and of the Council of 20 November 2013 amending Council Regulation (EC) No 111/2005 laying down rules for the monitoring of trade between the Community and third countries in drug precursors."
    },
    {
      "type": "F",
      "label": "F7",
      "text": "Substituted by Commission Delegated Regulation (EU) 2020/1737 of 14 July 2020 amending Regulation (EC) No 273/2004 of the European Parliament and of the Council and Council Regulation (EC) No 111/2005 as regards the inclusion of certain drug precursors in the list of scheduled substances (Text with EEA relevance)."
    },
    {
      "type": "F",
      "label": "F8",
      "text": "Substituted by Commission Delegated Regulation (EU) 2020/1737 of 14 July 2020 amending Regulation (EC) No 273/2004 of the European Parliament and of the Council and Council Regulation (EC) No 111/2005 as regards the inclusion of certain drug precursors in the list of scheduled substances (Text with EEA relevance)."
    },
    {
      "type": "F",
      "label": "F9",
      "text": "Substituted by Commission Delegated Regulation (EU) 2020/1737 of 14 July 2020 amending Regulation (EC) No 273/2004 of the European Parliament and of the Council and Council Regulation (EC) No 111/2005 as regards the inclusion of certain drug precursors in the list of scheduled substances (Text with EEA relevance)."
    },
    {
      "type": "F",
      "label": "F10",
      "text": "Substituted by Commission Delegated Regulation (EU) 2020/1737 of 14 July 2020 amending Regulation (EC) No 273/2004 of the European Parliament and of the Council and Council Regulation (EC) No 111/2005 as regards the inclusion of certain drug precursors in the list of scheduled substances (Text with EEA relevance)."
    },
    {
      "type": "footnote",
      "label": "f1",
      "text": "(1)OJ No. L 290, 28.10.2002, p. 1."
    },
    {
      "type": "footnote",
      "label": "f2",
      "text": "(2)The CAS No is the ‘Chemical abstracts service registry number’, which is a unique numeric identifier specific to each substance and its structure. The CAS No is specific to each isomer and to each salt of each isomer. The CAS Nos for the salts of the substances listed above will be different from those given."
    },
    {
      "type": "footnote",
      "label": "f3",
      "text": "(4)Also known as ethyl 3-oxo-2-phenylbutanoate, according to The International Union of Pure and Applied Chemistry (IUPAC)."
    },
    {
      "type": "footnote",
      "label": "f4",
      "text": "(6)And its ethyl, methyl (CAS No 80532-66-7), propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl esters, with the same CN code as BMK glycidic acid."
    },
    {
      "type": "footnote",
      "label": "f5",
      "text": "(5)Also known as methyl 2-(2H-1,3-benzodioxol-5-yl)-3-oxobutanoate, according to IUPAC."
    },
    {
      "type": "footnote",
      "label": "f6",
      "text": "(7)And its ethyl (CAS No 28578-16-7), methyl (CAS No 13605-48-6), propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl esters, with the same CN code as PMK glycidic acid."
    },
    {
      "type": "footnote",
      "label": "f7",
      "text": "(8)Also known as 5-[2-(1,3-benzodioxol-5-yl)acetyl]–2,2-dimethyl–1,3-dioxane–4,6-dione, according to IUPAC."
    },
    {
      "type": "footnote",
      "label": "f8",
      "text": "(3)Also named (+)-norpseudoephedrine, CN code 2939 43 00, CAS No 492-39-7."
    },
    {
      "type": "footnote",
      "label": "f9",
      "text": "(1)OJ No. L 290, 28.10.2002, p. 1."
    },
    {
      "type": "footnote",
      "label": "f10",
      "text": "(2)The CAS No is the ‘Chemical abstracts service registry number’, which is a unique numeric identifier specific to each substance and its structure. The CAS No is specific to each isomer and to each salt of each isomer. The CAS Nos for the salts of the substances listed above will be different from those given."
    },
    {
      "type": "footnote",
      "label": "f11",
      "text": "OJ L 290, 28.10.2002, p. 1."
    },
    {
      "type": "footnote",
      "label": "f12",
      "text": "The CAS No is the ‘Chemical abstracts service registry number’, which is a unique numeric identifier specific to each substance and its structure. The CAS No is specific to each isomer and to each salt of each isomer. It must be understood that the CAS Nos for the salts of the substances listed above will be different from those given."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eur/2005/111/annex",
    "retrieved_at": "2026-11-01T14:54:54.786055+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}