# Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC (Text with EEA relevance), Division 1.0.2: The human health hazard assessment shall consider the toxicokinetic profile (i.e. absorption, metabolism, distribution and elimination) of the substance and the following groups of effects:

Extent: E+W+S+N.I.

(1) acute effects such as acute toxicity, irritation and corrosivity;
(2) sensitisation;
(3) repeated dose toxicity; and
(4) CMR effects (carcinogenity, germ cell mutagenicity and toxicity for reproduction).
Based on all the available information, other effects shall be considered when necessary.

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Source: https://www.legislation.gov.uk/eur/2006/1907/annex/I/division/1/division/1.0/division/1.0.2 (the official version)
Page: https://openlegislation.uk/eu-regulation-2006-1907/annex-I/division-1/division-1.0/division-1.0.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.