{
  "url": "https://openlegislation.uk/eu-regulation-2006-1907/annex-I/division-5/division-5.2/division-5.2.4",
  "json_url": "https://openlegislation.uk/eu-regulation-2006-1907/annex-I/division-5/division-5.2/division-5.2.4.json",
  "legislation": "eur/2006/1907",
  "legislation_title": "Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC (Text with EEA relevance)",
  "legislation_url": "https://openlegislation.uk/eu-regulation-2006-1907",
  "path": "annex/I/division/5/division/5.2/division/5.2.4",
  "kind": "division",
  "number": "5.2.4",
  "heading": "An estimation of the exposure levels shall be performed for all human populations (workers, consumers and humans liable to exposure indirectly via the environment) and environmental spheres for which exposure to the substance is known or reasonably foreseeable. Each relevant route of human exposure (inhalation, oral, dermal and combined through all relevant routes and sources of exposure) shall be addressed. Such estimations shall take account of spatial and temporal variations in the exposure pattern. In particular, the exposure estimation shall take account of:",
  "text": "adequately measured, representative exposure data,\nany major impurities and additives in the substance,\nthe quantity in which the substance is produced and/or imported,\nthe quantity for each identified use,\nimplemented or recommended risk management, including the degree of containment,\nduration and frequency of exposure according to the operational conditions,\nthe activities of workers related to the processes and the duration and frequency of their exposure to the substance,\nthe activities of consumers and the duration and frequency of their exposure to the substance,\nthe duration and frequency of emissions of the substance to the different environmental compartments and the dilution in the receiving environmental compartment,\nthe physicochemical properties of the substance,\ntransformation and/or degradation products,\nthe likely routes of exposure of and potential for absorption in humans,\nthe likely pathways to the environment and environmental distribution and degradation and/or transformation (see also Section 3 Step 1),\nscale (geographical) of exposure,\nmatrix dependent release/migration of the substance.",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "X",
      "label": "X1",
      "text": "Substituted by Corrigendum to Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC (Official Journal of the European Union L 396 of 30 December 2006)."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eur/2006/1907/annex/I/division/5/division/5.2/division/5.2.4",
    "retrieved_at": "2026-11-01T14:53:13.283023+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}