# Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC (Text with EEA relevance), Annex XIV: LIST OF SUBSTANCES SUBJECT TO AUTHORISATION

Extent: E+W+S+N.I.

Date referred to in Article 58(1)(c)(ii) of Regulation (EC) No 1907/2006.
Date referred to in Article 58(1)(c)(i) of Regulation (EC) No 1907/2006.
1 September 2021 for the use of the substance in the production of spare parts as articles or as complex products for the repair of articles or complex products, the production of which ceased or will have ceased before the sunset date indicated in the entry for that substance, where that substance was used in the production of those articles or complex products and these cannot function as intended without that spare part and the spare part cannot be produced without that substance, and for the use of the substance (on its own or in a mixture) for the repair of such articles or complex products where that substance on its own or in a mixture was used in the production of those articles or complex products and they cannot be repaired otherwise than by using that substance.
1 March 2023 for the use of the substance in the production of spare parts as articles or as complex products for the repair of articles or complex products the production of which ceased or will have ceased before the sunset date indicated in the entry for that substance, where that substance was used in the production of those articles or complex products and these cannot function as intended without those spare parts and the spare part cannot be produced without that substance, and for the use of the substance (on its own or in a mixture) for the repair of such articles or complex products, where that substance on its own or in a mixture was used in the production of those articles or complex products and they cannot be repaired otherwise than by using that substance.
Does not meet the criteria for identification as a carcinogen if it contains < 0,005 % (w/w) benzo[a]pyrene (Einecs No 200-028-5).
Regulation (EU) 2017/746 of the European Parliament and of the Council of 5 April 2017 on in vitro diagnostic medical devices and repealing Directive 98/79/EC and Commission Decision 2010/227/EU ( OJ L 117, 5.5.2017, p. 176 ).
Entry Nr
Substance
Intrinsic property(ies) referred to in Article 57
Transitional arrangements
Exempted (categories of) uses
Review periods
Latest application date
Sunset date
1.
5-tert-butyl-2,4,6-trinitro-m-xylene
( Musk xylene )
EC No 201-329-4
CAS No 81-15-2
vPvB
21 February 2013
21 August 2014
—
—
2.
4,4’-Diaminodiphenylmethane
(MDA)
EC No 202-974-4
CAS No 101-77-9
Carcinogenic
(category 1B)
21 February 2013
21 August 2014
—
—
3.
Hexabromocyclododecane
( HBCDD )
EC No 221-695-9,
247-148-4,
CAS No 3194-55-6
25637-99-4
alpha-hexabromocyclododecane
CAS No 134237-50-6,
beta-hexabromocyclododecane
CAS No 134237-51-7
gamma-hexabromocyclododecane
CAS No 134237-52-8
PBT
21 February 2014
21 August 2015
—
—
4.
Bis(2-ethylhexyl) phthalate
( DEHP )
EC No 204-211-0
CAS No 117-81-7
Toxic for reproduction
(category 1B)
21 August 2013
21 February 2015
Uses in the immediate packaging of medicinal products covered under Regulation (EC) No 726/2004, the Veterinary Medicines Regulations 2013 or the Human Medicines Regulations 2012 .
5.
Benzyl butyl phthalate
( BBP )
EC No 201-622-7
CAS No 85-68-7
Toxic for reproduction
(category 1B)
21 August 2013
21 February 2015
Uses in the immediate packaging of medicinal products covered under Regulation (EC) No 726/2004, Directive 2001/82/EC, and/or Directive 2001/83/EC.
6.
Dibutyl phthalate
( DBP )
EC No 201-557-4
CAS No 84-74-2
Toxic for reproduction
(category 1B)
21 August 2013
21 February 2015
Uses in the immediate packaging of medicinal products covered under Regulation (EC) No 726/2004, Directive 2001/82/EC, and/or Directive 2001/83/EC.
7.
Diisobutyl phthalate (DIBP)
EC No: 201-553-2
CAS No: 84-69-5
Toxic for reproduction
(category 1B)
21 August 2013
21 February 2015
—
—
8.
Diarsenic trioxide
EC No: 215-481-4
CAS No: 1327-53-3
Carcinogenic
(category 1A)
21 November 2013
21 May 2015
—
—
9.
Diarsenic pentaoxide
EC No: 215-116-9
CAS No: 1303-28-2
Carcinogenic
(category 1A)
21 November 2013
21 May 2015
—
—
10.
Lead chromate
EC No: 231-846-0
CAS No: 7758-97-6
Carcinogenic
(category 1B)
Toxic for reproduction
(category 1A)
21 November 2013
21 May 2015
—
—
11.
Lead sulfochromate yellow
(C.I. Pigment Yellow 34)
EC No: 215-693-7
CAS No: 1344-37-2
Carcinogenic
(category 1B)
Toxic for reproduction
(category 1A)
21 November 2013
21 May 2015
—
—
12.
Lead chromate molybdate sulphate red
(C.I. Pigment Red 104)
EC No: 235-759-9
CAS No: 12656-85-8
Carcinogenic
(category 1B)
Toxic for reproduction
(category 1A)
21 November 2013
21 May 2015
13.
Tris (2-chloroethyl) phosphate
(TCEP)
EC No: 204-118-5
CAS No: 115-96-8
Toxic for reproduction
(category 1B)
21 February 2014
21 August 2015
14.
2,4-Dinitrotoluene (2,4-DNT)
EC No: 204-450-0
CAS No: 121-14-2
Carcinogenic
(category 1B)
21 February 2014
21 August 2015
15.
Trichloroethylene
EC No: 201-167-4
CAS No: 79-01-6
Carcinogenic
(category 1B)
21 October 2014
21 April 2016
—
—
16.
Chromium trioxide
EC No: 215-607-8
CAS No: 1333-82-0
Carcinogenic
(category 1A)
Mutagenic
(category 1B)
21 March 2016
21 September 2017
—
—
17.
Acids generated from chromium trioxide and their oligomers
Group containing:
Chromic acid
EC No: 231-801-5
CAS No: 7738-94-5
Dichromic acid
EC No: 236-881-5
CAS No: 13530-68-2
Oligomers of chromic acid and dichromic acid
EC No: not yet assigned
CAS No: not yet assigned
Carcinogenic
(category 1B)
21 March 2016
21 September 2017
—
—
18.
Sodium dichromate
EC No: 234-190-3
CAS No: 7789-12-0
10588-01-9
Carcinogenic
(category 1B)
Mutagenic
(category 1B)
Toxic for reproduction
(category 1B)
21 March 2016
21 September 2017
—
—
19.
Potassium dichromate
EC No: 231-906-6
CAS No: 7778-50-9
Carcinogenic
(category 1B)
Mutagenic
(category 1B)
Toxic for reproduction
(category 1B)
21 March 2016
21 September 2017
—
—
20.
Ammonium dichromate
EC No: 232-143-1
CAS No: 7789-09-5
Carcinogenic
(category 1B)
Mutagenic
(category 1B)
Toxic for reproduction
(category 1B)
21 March 2016
21 September 2017
21.
Potassium chromate
EC No: 232-140-5
CAS No: 7789-00-6
Carcinogenic
(category 1B)
Mutagenic
(category 1B)
21 March 2016
21 September 2017
22.
Sodium chromate
EC No: 231-889-5
CAS No: 7775-11-3
Carcinogenic
(category 1B)
Mutagenic
(category 1B)
Toxic for reproduction
(category 1B)
21 March 2016
21 September 2017
23.
Formaldehyde, oligomeric reaction products with aniline (technical MDA)
EC No: 500-036-1
CAS No: 25214-70-4
Carcinogenic
(category 1B)
22 February 2016
22 August 2017
—
—
24.
Arsenic acid
EC No: 231-901-9
CAS No: 7778-39-4
Carcinogenic
(category 1A)
22 February 2016
22 August 2017
—
—
25.
Bis(2-methoxyethyl) ether (diglyme)
EC No: 203-924-4
CAS No: 111-96-6
Toxic for reproduction
(category 1B)
22 February 2016
22 August 2017
—
—
26.
1,2-dichloroethane (EDC)
EC No: 203-458-1
CAS No: 107-06-2
Carcinogenic
(category 1B)
22 May 2016
22 November 2017
—
—
27.
2,2′-dichloro-4,4′-methylenedianiline (MOCA)
EC No: 202-918-9
CAS No: 101-14-4
Carcinogenic
(category 1B)
22 May 2016
22 November 2017
—
—
28.
Dichromium tris(chromate)
EC No: 246-356-2
CAS No: 24613-89-6
Carcinogenic
(category 1B)
22 July 2017
22 January 2019
—
—
29.
Strontium chromate
EC No: 232-142-6
CAS No: 7789-06-2
Carcinogenic
(category 1B)
22 July 2017
22 January 2019
—
—
30.
Potassium hydroxyoctaoxodizincatedichromate
EC No: 234-329-8
CAS No: 11103-86-9
Carcinogenic
(category 1A)
22 July 2017
22 January 2019
—
—
31.
Pentazinc chromate octahydroxide
EC No: 256-418-0
CAS No: 49663-84-5
Carcinogenic
(category 1A)
22 July 2017
22 January 2019
—
—
32.
1-Bromopropane (n-propyl bromide)
EC No 203-445-0
CAS No 106-94-5
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
33.
Diisopentylphthalate
EC No 210-088-4
CAS No 605-50-5
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
34.
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7 rich
EC No 276-158-1
CAS No 71888-89-6
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
35.
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters
EC No 271-084-6
CAS No 68515-42-4
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
36.
1,2-Benzenedicarboxylic acid, dipentylester, branched and linear
EC No 284-032-2
CAS No 84777-06-0
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
37.
Bis(2-methoxyethyl) phthalate
EC No 204-212-6
CAS No 117-82-8
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
38.
Dipentylphthalate
EC No 205-017-9
CAS No 131-18-0
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
39.
N-pentyl-isopentylphthalate
EC No —
CAS No 776297-69-9
Toxic for reproduction
(category 1B)
4 January 2019
4 July 2020
—
—
40.
Anthracene oil
EC No 292-602-7
CAS No 90640-80-5
Carcinogenic
(category 1B) , PBT, vPvB
4 April 2019
4 October 2020
—
—
41.
Pitch, coal tar, high temp.
EC No 266-028-2
CAS No 65996-93-2
Carcinogenic
(category 1B), PBT, vPvB
4 April 2019
4 October 2020
—
—
42.
4-(1,1,3,3-Tetramethylbutyl)phenol, ethoxylated
(covering well-defined substances and UVCB substances, polymers and homologues)
EC No —
CAS No —
Endocrine disrupting properties (Article 57(f) — environment)
( a ) 4 July 2019 ;
( b ) by way of derogation from point (a), 22 June 2022 for uses as follows:
— for the research, development and production of medicinal products falling within the scope of the Human Medicines Regulations 2012 or relevant medical devices or relevant accessories to medical devices ... in view of their use for the diagnosis, treatment or prevention of the coronavirus disease (COVID-19),
— in relevant medical devices or relevant accessories to medical devices ... for the diagnosis, treatment or prevention of COVID-19.
( a ) 4 January 2021 ;
( b ) by way of derogation from point (a), 22 December 2023 for uses as follows:
— for the research, development and production of medicinal products falling within the scope of the Human Medicines Regulations 2012 or relevant medical devices or relevant accessories to medical devices ... in view of their use for the diagnosis, treatment or prevention of COVID-19,
— in relevant medical devices or relevant accessories to medical devices ... for the diagnosis, treatment or prevention of COVID-19.
—
—
43.
4-Nonylphenol, branched and linear, ethoxylated
(substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof)
EC No —
CAS No —
Endocrine disrupting properties (Article 57(f) — environment)
4 July 2019
4 January 2021
—
—
44.
1,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear
EC No: 271-093-5
CAS No: 68515-50-4
Toxic for reproduction (category 1B)
27 August 2021
27 February 2023
—
—
45.
Dihexyl phthalate
EC No: 201-559-5
CAS No: 84-75-3
Toxic for reproduction (category 1B)
27 August 2021
27 February 2023
—
—
46.
1,2-benzenedicarboxylic acid, di-C6-10-alkyl esters; 1,2-benzenedicarboxylic acid, mixed decyl and hexyl and octyl diesters with ≥ 0,3 % of dihexyl phthalate (EC No 201-559-5)
EC No: 271-094-0; 272-013-1
CAS No: 68515-51-5; 68648-93-1
Toxic for reproduction (category 1B)
27 August 2021
27 February 2023
—
—
47.
Trixylyl phosphate
EC No: 246-677-8
CAS No: 25155-23-1
Toxic for reproduction (category 1B)
27 November 2021
27 May 2023
—
—
48.
Sodium perborate; perboric acid, sodium salt
EC No: 239-172-9; 234-390-0
CAS No: -
Toxic for reproduction (category 1B)
27 November 2021
27 May 2023
—
—
49.
Sodium peroxometaborate
EC No: 231-556-4
CAS No: 7632-04-4
Toxic for reproduction (category 1B)
27 November 2021
27 May 2023
—
—
50.
5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] [covering any of the individual stereoisomers of [1] and [2] or any combination thereof]
EC No: -
CAS No: -
vPvB
27 February 2022
27 August 2023
—
—
51.
2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328)
EC No: 247-384-8
CAS No: 25973-55-1
PBT, vPvB
27 May 2022
27 November 2023
—
—
52.
2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327)
EC No: 223-383-8
CAS No: 3864-99-1
vPvB
27 May 2022
27 November 2023
—
—
53.
2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350)
EC No: 253-037-1
CAS No: 36437-37-3
vPvB
27 May 2022
27 November 2023
—
—
54.
2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320)
EC No: 223-346-6
CAS No: 3846-71-7
PBT, vPvB
27 May 2022
27 November 2023
—
—

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Source: https://www.legislation.gov.uk/eur/2006/1907/annex/XIV (the official version)
Page: https://openlegislation.uk/eu-regulation-2006-1907/annex-XIV
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.