Division 3.1.2 Criteria for classification of substances as acutely toxic

United Kingdom

1. 3.1.2.1Substances can be allocated to one of four hazard categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric cut-off criteria as shown in the table below. Acute toxicity values are expressed as (approximate) LD 50 (oral, dermal) or LC 50 (inhalation) values or as acute toxicity estimates (ATE). While some in vivo methods determine LD 50 /LC 50 values directly, other newer in vivo methods (e.g. using fewer animals) consider other indicators of acute toxicity, such as significant clinical signs of toxicity, which are used as a reference to assign the hazard category. Explanatory notes are shown following Table 3.1.1.
2. 3.1.2.2Specific considerations for classification of substances as acutely toxic
3. 3.1.2.3Specific considerations for classification of substances as acutely toxic by the inhalation route