{
  "url": "https://openlegislation.uk/eu-regulation-2008-1272/annex-I/division-3/division-3.3/division-3.3.2/division-3.3.2.1/division-3.3.2.1.2",
  "json_url": "https://openlegislation.uk/eu-regulation-2008-1272/annex-I/division-3/division-3.3/division-3.3.2/division-3.3.2.1/division-3.3.2.1.2.json",
  "legislation": "eur/2008/1272",
  "legislation_title": "Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (Text with EEA relevance)",
  "legislation_url": "https://openlegislation.uk/eu-regulation-2008-1272",
  "path": "annex/I/division/3/division/3.3/division/3.3.2/division/3.3.2.1/division/3.3.2.1.2",
  "kind": "division",
  "number": "3.3.2.1.2",
  "heading": "Eye irritation (Category 2)",
  "text": "Table 3.3.2\nEye irritation\nGrading criteria are understood as described in Regulation (EC) No 440/2008.\nCategory\nCriteria\nCategory 2\nSubstances that produce in at least 2 of 3 tested animals a positive response of:\n(a) corneal opacity ≥ 1; and/or\n(b) iritis ≥ 1; and/or\n(c) conjunctival redness ≥ 2; and/or\n(d) conjunctival oedema (chemosis) ≥ 2\ncalculated as the mean scores following grading at 24, 48 and 72 hours after instillation of the test material, and which fully reverses within an observation period of normally 21 days.",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [
    {
      "type": "F",
      "label": "F1",
      "text": "Substituted by Commission Regulation (EU) 2016/918 of 19 May 2016 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (Text with EEA relevance)."
    },
    {
      "type": "footnote",
      "label": "f1",
      "text": "Grading criteria are understood as described in Regulation (EC) No 440/2008."
    }
  ],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eur/2008/1272/annex/I/division/3/division/3.3/division/3.3.2/division/3.3.2.1/division/3.3.2.1.2",
    "retrieved_at": "2026-11-01T14:51:47.470832+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}