Division 3.9.2 Classification criteria for substances

United Kingdom

1. 3.9.2.1Substances are classified as specific target organ toxicants following repeated exposure by the use of expert judgement (see 1.1.1), on the basis of the weight of all evidence available, including the use of recommended guidance values which take into account the duration of exposure and the dose/concentration which produced the effect(s), (see 3.9.2.9), and are placed in one of two categories, depending upon the nature and severity of the effect(s) observed (Table 3.9.1).
2. 3.9.2.2Division 3.9.2.2
3. 3.9.2.3Division 3.9.2.3
4. 3.9.2.4Division 3.9.2.4
5. 3.9.2.5Division 3.9.2.5
6. 3.9.2.6In exceptional cases, based on expert judgement, it is appropriate to place certain substances with human evidence of specific target organ toxicity in Category 2:
7. 3.9.2.7Effects considered to support classification for specific target organ toxicity following repeated exposure
8. 3.9.2.8Effects considered not to support classification for specific target organ toxicity following repeated exposure
9. 3.9.2.9Guidance values to assist with classification based on the results obtained from studies conducted in experimental animals
10. 3.9.2.10Other considerations