{
  "url": "https://openlegislation.uk/eu-regulation-2008-429/annex-II/division-3/division-3.1/division-3.1.1/division-3.1.1.2",
  "json_url": "https://openlegislation.uk/eu-regulation-2008-429/annex-II/division-3/division-3.1/division-3.1.1/division-3.1.1.2.json",
  "legislation": "eur/2008/429",
  "legislation_title": "Commission Regulation (EC) No 429/2008 of 25 April 2008 on detailed rules for the implementation of Regulation (EC) No 1831/2003 of the European Parliament and of the Council as regards the preparation and the presentation of applications and the assessment and the authorisation of feed additives (Text with EEA relevance)",
  "legislation_url": "https://openlegislation.uk/eu-regulation-2008-429",
  "path": "annex/II/division/3/division/3.1/division/3.1.1/division/3.1.1.2",
  "kind": "division",
  "number": "3.1.1.2",
  "heading": "Duration of tolerance trials",
  "text": "Table 1\nDuration of tolerance trials: Pigs\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nSuckling piglets\n14 days\nPreferably from 14 days to weaning\nWeaned piglets\n42 days\nFor 42 days after weaning\nPigs for fattening\n42 days\nBody weight at start of the study ≤ 35 kg\nSows for reproduction\n1 cycle\nFrom insemination to the end of the weaning period\nIf suckling and weaned piglets are applied for, a combined study (14 days suckling piglets and 28 days weaned piglets) would be considered sufficient. If the tolerance for weaned piglets has been shown, no separate study for pigs for fattening is required.\nTable 2\nDuration of tolerance trials: Poultry\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nChickens for fattening/reared for laying\n35 days\nFrom hatching\nLaying hens\n56 days\nPreferably during the first third of the laying period\nTurkeys for fattening\n42 days\nFrom hatching\nTolerance data from chickens for fattening or turkeys for fattening can be used to demonstrate tolerance for chickens or turkeys reared for laying/breeding respectively.\nTable 3\nDuration of tolerance trials: Bovines\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nCalves for fattening\n28 days\nInitial bodyweight ≤ 70kg\nCalves for rearing; cattle for fattening or reproduction\n42 days\nDairy cows\n56 days\nIf calves for rearing and cattle for fattening were applied for, a combined study (28 days for each period) would be considered sufficient.\nTable 4\nDuration of tolerance trials: Sheep\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nLambs for rearing and for fattening\n28 days\nTable 5\nDuration of tolerance trials: Salmonidae and other fish\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nSalmon and trout\n90 days\nAs an alternative to a 90-day duration, a study could be performed where the fish increase their initial body weight at the start of the trial by least a factor of two.\nIf the additive is intended to be used for brood stock only, the tolerance tests shall be carried out as close to the spawning period as possible. The tolerance tests shall last for 90 days and attention shall be paid to the egg quality and survival of the eggs.\nTable 6\nDuration of tolerance trials: Pets and other non food-producing animals\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nDogs and cats\n28 days\nTable 7\nDuration of tolerance trials: Rabbits\nTarget animals\nDuration of the studies\nCharacteristic of the target animals\nRabbits for fattening\n28 days\nBreeding does\n1 cycle\nFrom insemination to the end of the weaning period\nIf rabbits suckling and weaned are applied for, a period of 49 days (beginning one week after birth) would be considered sufficient and must include the does until weaning.\nIf an additive is applied for a specific and shorter period than given by the animal category definition, it shall be administered according to the proposed conditions of use. However, the observation period shall not be shorter than 28 days and shall involve the relevant end-point (e.g. for sows for reproduction the number of piglets born alive when considering the gestation period, or the number and weight of weaned piglets when considering the lactation period).",
  "extent": "E+W+S+N.I.",
  "status": null,
  "version": "current",
  "annotations": [],
  "outstanding_effects": [],
  "provenance": {
    "source": "legislation.gov.uk",
    "source_url": "https://www.legislation.gov.uk/eur/2008/429/annex/II/division/3/division/3.1/division/3.1.1/division/3.1.1.2",
    "retrieved_at": "2026-11-01T14:52:17.021143+00:00"
  },
  "licence": "Open Government Licence v3.0",
  "licence_url": "https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/",
  "attribution": "Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives."
}