Division 1.5 DEMONSTRATION OF PROFICIENCY
United Kingdom
Prior to routine use of a validated method that adheres to this Test Method, laboratories may wish to demonstrate technical proficiency, using the ten substances recommended in Table 1. Under this Test Method, the UN GHS optional category 3 is considered as no category. For novel similar (me-too) test methods developed under this Test Method that are structurally and functionally similar to the validated reference methods or for modifications of validated methods, the performance standards described in the Appendix to this Test Method should be used to demonstrate comparable reliability and accuracy of the new test method prior to its use for regulatory testing.
Table 1
Proficiency Substances which are a subset of the Reference Substances listed in the Appendix
| Substance | CAS Number | In vivo score | Physical state | GHS category |
|---|---|---|---|---|
| naphthalene acetic acid | 86-87-3 | 0 | S | No Cat. |
| isopropanol | 67-63-0 | 0,3 | L | No Cat. |
| methyl stearate | 112-61-8 | 1 | S | No Cat. |
| heptyl butyrate | 5870-93-9 | 1,7 | L | Optional Cat. 3 |
| hexyl salicylate | 6259-76-3 | 2 | L | Optional Cat. 3 |
| cyclamen aldehyde | 103-95-7 | 2,3 | L | Cat. 2 |
| 1-bromohexane | 111-25-1 | 2,7 | L | Cat. 2 |
| butyl methacrylate | 97-88-1 | 3 | L | Cat. 2 |
| 1-methyl-3-phenyl-1-piperazine | 5271-27-2 | 3,3 | S | Cat. 2 |
| Heptanal | 111-71-7 | 4 | L | Cat. 2 |