# Commission Regulation (EU) No 544/2011 of 10 June 2011 implementing Regulation (EC) No 1107/2009 of the European Parliament and of the Council as regards the data requirements for active substances (Text with EEA relevance) (repealed), Division 2.7: Solubility in organic solvents

Extent: E+W+S+N.I.

The solubility of the active substances as manufactured in the following organic solvents at 15 to 25 °C must be determined and reported if less than 250 g/kg; the temperature applied must be specified:
Aliphatic hydrocarbon: preferably n-heptane,
Aromatic hydrocarbon: preferably xylene,
Halogenated hydrocarbon: preferably 1,2-dichlorethane,
Alcohol: preferably methanol or isopropyl alcohol,
Ketone: preferably acetone,
Ester: preferably ethyl acetate.
If for a particular active substance, one or more of these solvents are unsuitable (e.g. reacts with test material), alternative solvents can be used instead. In such cases, the choices made must be justified in terms of their structure and polarity.

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Source: https://www.legislation.gov.uk/eur/2011/544/annex/part/A/division/2/division/2.7 (the official version)
Page: https://openlegislation.uk/eu-regulation-2011-544/annex/part-A/division-2/division-2.7
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.