# Commission Regulation (EU) No 546/2011 of 10 June 2011 implementing Regulation (EC) No 1107/2009 of the European Parliament and of the Council as regards uniform principles for evaluation and authorisation of plant protection products (Text with EEA relevance), Division 2.8.2.2

Extent: E+W+S+N.I.

A plant protection product may give rise to toxic effects due to the action of toxins or co-formulants. For the assessment of such effects the following information shall be taken into consideration:
(a)studies on toxicity to aquatic organisms;
(b)information on fate and behaviour in the various parts of the environment.
If mortality or signs of intoxication are observed in the tests the evaluation must include a calculation of toxicity/exposure ratios based on the quotient of the EC50 value and/or the NOEC value and the estimated exposure.

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Source: https://www.legislation.gov.uk/eur/2011/546/annex/part/II/division/B/division/2/division/2.8/division/2.8.2/division/2.8.2.2 (the official version)
Page: https://openlegislation.uk/eu-regulation-2011-546/annex/part-II/division-B/division-2/division-2.8/division-2.8.2/division-2.8.2.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.