# Commission Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market (Text with EEA relevance), Division 2.6: Solubility in organic solvents

Extent: E+W+S+N.I.

The solubility of the active substances as manufactured or purified active substance in the following organic solvents at 15 to 25 °C shall be determined and reported if less than 250 g/L; the temperature applied shall be specified. Results shall be reported as g/L.
(a)Aliphatic hydrocarbon: preferably heptane
(b)Aromatic hydrocarbon: preferably toluene
(c)Halogenated hydrocarbon: preferably dichloromethane
(d)Alcohol: preferably methanol or isopropyl alcohol
(e)Ketone: preferably acetone
(f)Ester: preferably ethyl acetate.
If for a particular active substance, one or more of those solvents is unsuitable (for example reacts with test material), alternative solvents may be used instead. In such cases, choices of solvents shall be justified in terms of their structure and polarity.

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Source: https://www.legislation.gov.uk/eur/2013/283/annex/section/2/division/2.6 (the official version)
Page: https://openlegislation.uk/eu-regulation-2013-283/annex/section-2/division-2.6
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.