# Commission Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market (Text with EEA relevance), Division 5.4: Genotoxicity testing

Extent: E+W+S+N.I.

The aim of genotoxicity testing shall be to:
predict genotoxic potential,
identify genotoxic carcinogens at an early stage,
elucidate the mechanism of action of some carcinogens.
Appropriate dose levels, depending on the test requirements, shall be used in either in vitro or in vivo assays. A tiered approach shall be adopted, with selection of higher tier tests being dependent upon interpretation of results at each stage.
Special testing requirements in relation to photomutagenicity may be indicated by the structure of a molecule. If the Ultraviolet/visible molar extinction/absorption coefficient of the active substance and its major metabolites is less than 1 000 L × mol–1 × cm–1, photomutagenicity testing is not required.

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Source: https://www.legislation.gov.uk/eur/2013/283/annex/section/5/division/5.4 (the official version)
Page: https://openlegislation.uk/eu-regulation-2013-283/annex/section-5/division-5.4
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.