# Commission Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market (Text with EEA relevance), Division: Circumstances in which required

Extent: E+W+S+N.I.

A reproduction toxicity study in rats over at least two generations shall be reported.
The OECD extended one-generation reproductive toxicity study may be considered as an alternative approach to the multi-generation study.
Where necessary for a better interpretation of the effects on reproduction and as far as this information is not yet available, supplementary studies may be required to provide information on the affected gender and the possible mechanisms.

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Source: https://www.legislation.gov.uk/eur/2013/283/annex/section/5/division/5.6/division/5.6.1/division/1 (the official version)
Page: https://openlegislation.uk/eu-regulation-2013-283/annex/section-5/division-5.6/division-5.6.1/division-1
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.