# Commission Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market (Text with EEA relevance), Division 5.7.2: Delayed polyneuropathy studies

Extent: E+W+S+N.I.

Delayed polyneuropathy studies shall provide sufficient data to evaluate if the active substance may provoke delayed polyneuropathy after acute and repeated exposure. A repeated exposure study may be waived unless there are indications that the compound accumulates and significant inhibition of neuropathy target esterase or clinical/histopathological signs of delayed polyneuropathy occur at around the hen LD50 as determined in the single dose test.

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Source: https://www.legislation.gov.uk/eur/2013/283/annex/section/5/division/5.7/division/5.7.2 (the official version)
Page: https://openlegislation.uk/eu-regulation-2013-283/annex/section-5/division-5.7/division-5.7.2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.